Sodium Phenylbutyrate

Catalog No.S4125

Sodium Phenylbutyrate Chemical Structure

Molecular Weight(MW): 186.18

Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 970 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • Representative images and quantitative analysis results of the transwell experiment. Notes: (A) Results of migration assay for DU145. (B) Results of invasion assay for DU145. (C) Results of migration assay for PC3. (D) Results of invasion assay for PC3. “*” Means significantly different from control group, P<0.05. Abbreviation: SPB, sodium phenylbutyrate.

    OncoTargets and Therapy, 2016, 9:2825-2833.. Sodium Phenylbutyrate purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
HDAC [1]
In vitro

Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. [1] Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
VA10 cells NF7SNGNHfW6ldHnvckBie3OjeR?= M1rSNWlv\HWldHnvckBw\iCOTD2zO{Bxem:2ZXnuJIV5eHKnc4Ppc44hcW5iaIXtZY4hXkFzMDDj[YxteyCjdDCyNEBvVSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[y=> NULTOWlzOTl5N{CyO|M>
A498 cells MVfGeY5kfGmxbjDhd5NigQ>? M1\WSVQhdU1? M{PUdlguPDhiaB?= MVXJcoR2[3Srb36gc4YhS0GPUDDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iQUS5PEBk\WyuczDheEA1KG2PIHHmeIVzKDhidH:gOFghcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= MW[xPVc4ODJ5Mx?=
HT-29 cells NVqwbY1vTnWwY4Tpc44h[XO|YYm= MXG0JI1O NVv0Ung1QC12ODDo M{DwNmlv\HWldHnvckBw\iCFQV3QJI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDIWE0zQSClZXzsd{BifCB2IH3NJIFnfGW{IEigeI8hPDhiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> NHm2XJMyQTd5MEK3Ny=>
U937 cells Mn;qSpVv[3Srb36gZZN{[Xl? MU[0JI1O NXTZVIk6QC12ODDo MVTJcoR2[3Srb36gc4YhS0GPUDDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iVUmzO{Bk\WyuczDheEA1KG2PIHHmeIVzKDhidH:gOFghcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= NFi5VFIyQTd5MEK3Ny=>
Hela cells MnHNSpVv[3Srb36gZZN{[Xl? M4PTW2lvcGmkaYTpc44hd2ZiSFTBR{BqdiCqdX3hckBJ\WyjIHPlcIx{KG63Y3zlZZIh\Xi2cnHjeJMh[nliZnz1c5JqdWW2cnnjJIF{e2G7 MkHVNVk2OjB3OEC=

... Click to View More Cell Line Experimental Data

In vivo Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. [3] Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington's disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum. [4]


Solubility (25°C)

In vitro Water 30 mg/mL (161.13 mM)
DMSO 8 mg/mL (42.96 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.18


CAS No. 1716-12-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02343094 Completed Proteinuric Diseases Assistance Publique - Hôpitaux de Paris February 2015 Phase 2|Phase 3
NCT02246218 Completed Urea Cycle Disorder Horizon Therapeutics LLC|Horizon Pharma Ireland Ltd. Dublin Ireland December 2014 Phase 4
NCT02111200 Completed Urea Cycle Disorders Inborn Baylor College of Medicine September 2014 Not Applicable
NCT02046434 Active not recruiting Parkinson''s Disease University of Colorado Denver January 2014 Phase 1
NCT01529060 Active not recruiting Maple Syrup Urine Disease Brendan Lee|Baylor College of Medicine February 2013 Phase 2|Phase 3
NCT01580007 Completed Pulmonary Tuberculosis International Centre for Diarrhoeal Disease Research Bangladesh|Karolinska Institutet|National Tuberculosis Reference Laboratory National Institute of Diseases of Chest and Hospital (NIDCH) Dhaka Bangladesh|University of Iceland December 2010 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

HDAC Signaling Pathway Map

Related HDAC Products

Tags: buy Sodium Phenylbutyrate | Sodium Phenylbutyrate supplier | purchase Sodium Phenylbutyrate | Sodium Phenylbutyrate cost | Sodium Phenylbutyrate manufacturer | order Sodium Phenylbutyrate | Sodium Phenylbutyrate distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID