Sodium Phenylbutyrate

Catalog No.S4125

Sodium Phenylbutyrate Chemical Structure

Molecular Weight(MW): 186.18

Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.

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In DMSO USD 130 In stock
USD 60 In stock
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Cited by 4 Publications

1 Customer Review

  • Representative images and quantitative analysis results of the transwell experiment. Notes: (A) Results of migration assay for DU145. (B) Results of invasion assay for DU145. (C) Results of migration assay for PC3. (D) Results of invasion assay for PC3. “*” Means significantly different from control group, P<0.05. Abbreviation: SPB, sodium phenylbutyrate.

    OncoTargets and Therapy, 2016, 9:2825-2833.. Sodium Phenylbutyrate purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
Targets
HDAC [1]
In vitro

Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. [1] Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
VA10 cells MVLGeY5kfGmxbjDhd5NigQ>? Mn3LTY5lfWO2aX;uJI9nKEyOLUO3JJBzd3SnaX6g[ZhxemW|c3nvckBqdiCqdX3hckBXSTFyIHPlcIx{KGG2IEKwJI5OKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3S2aX7n NHXBZlkyQTd5MEK3Ny=>
A498 cells NUm0cYFsTnWwY4Tpc44h[XO|YYm= MYi0JI1O M4rSO|guPDhiaB?= NV7w[FE{UW6mdXP0bY9vKG:oIFPBUXAhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGE1QThiY3XscJMh[XRiNDDtUUBi\nSncjC4JJRwKDR6IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> MonSNVk4PzB{N{O=
HT-29 cells MYnGeY5kfGmxbjDhd5NigQ>? NGiycY41KG2P MmTOPE01QCCq M3fDOmlv\HWldHnvckBw\iCFQV3QJI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDIWE0zQSClZXzsd{BifCB2IH3NJIFnfGW{IEigeI8hPDhiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> NHTNeoEyQTd5MEK3Ny=>
U937 cells NH;seolHfW6ldHnvckBie3OjeR?= M1fEfFQhdU1? MoLRPE01QCCq NVrmT2REUW6mdXP0bY9vKG:oIFPBUXAhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJHU6OzdiY3XscJMh[XRiNDDtUUBi\nSncjC4JJRwKDR6IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> MlPZNVk4PzB{N{O=
Hela cells NV\tVZp2TnWwY4Tpc44h[XO|YYm= NGK3XIRKdmirYnn0bY9vKG:oIFjERWMhcW5iaIXtZY4hUGWuYTDj[YxteyCwdXPs[YFzKGW6dILhZ5R{KGK7IH\seY9zcW2ndILpZ{Bie3OjeR?= MVSxPVUzODV6MB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Survivin; 

PubMed: 27274278     


(A) SPB treatment remarkably inhibited the expression of survivin in both cell types. SPB, sodium phenylbutyrate.

p38 / p-p38 / ERK / p-ERK / JNK / p-JNK ; 

PubMed: 27274278     


(B) SPB treatment increased the phosphorylation of p38 and ERK, while it had no effect on the activity of JNK. SPB, sodium phenylbutyrate.

27274278
In vivo Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. [3] Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington's disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum. [4]

Protocol

Solubility (25°C)

In vitro Water 30 mg/mL (161.13 mM)
DMSO 8 mg/mL (42.96 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.18
Formula

C10H11O2.Na

CAS No. 1716-12-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02246218 Completed Drug: RAVICTI Urea Cycle Disorder Horizon Therapeutics LLC|Horizon Pharma Ireland Ltd. Dublin Ireland December 31 2014 Phase 4
NCT01096095 Withdrawn Drug: Placebo|Drug: Sodium Phenylbutyrate Spinocerebellar Ataxia Type 3 Hospital de Clinicas de Porto Alegre|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Brazil June 2010 Phase 2
NCT00947544 Completed Drug: HPN-100|Drug: NaPBA Urea Cycle Disorders Horizon Pharma Ireland Ltd. Dublin Ireland March 2010 Phase 2
NCT00528268 Completed Drug: Sodium phenylbutyrate (NaPB) Spinal Muscular Atrophy University of Utah|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) July 2007 Phase 1|Phase 2
NCT00107770 Completed Drug: sodium phenylbutyrate Amyotrophic Lateral Sclerosis US Department of Veterans Affairs|Muscular Dystrophy Association|VA Office of Research and Development April 2005 Phase 1|Phase 2
NCT00005639 Completed Drug: Azacitidine Injection|Drug: sodium phenylbutyrate Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor Protocol Specific Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) March 2000 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID