Molecular Weight(MW): 186.18
Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
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Representative images and quantitative analysis results of the transwell experiment. Notes: (A) Results of migration assay for DU145. (B) Results of invasion assay for DU145. (C) Results of migration assay for PC3. (D) Results of invasion assay for PC3. “*” Means significantly different from control group, P<0.05. Abbreviation: SPB, sodium phenylbutyrate.
OncoTargets and Therapy, 2016, 9:2825-2833.. Sodium Phenylbutyrate purchased from Selleck.
Purity & Quality Control
Choose Selective HDAC Inhibitors
|Description||Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.|
Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra.  Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells. 
|In vivo||Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50.  Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington's disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum. |
|In vitro||Water||30 mg/mL (161.13 mM)|
|DMSO||8 mg/mL (42.96 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02246218||Completed||Drug: RAVICTI||Urea Cycle Disorder||Horizon Therapeutics LLC|Horizon Pharma Ireland Ltd. Dublin Ireland||December 31 2014||Phase 4|
|NCT01096095||Withdrawn||Drug: Placebo|Drug: Sodium Phenylbutyrate||Spinocerebellar Ataxia Type 3||Hospital de Clinicas de Porto Alegre|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Brazil||June 2010||Phase 2|
|NCT00947544||Completed||Drug: HPN-100|Drug: NaPBA||Urea Cycle Disorders||Horizon Pharma Ireland Ltd. Dublin Ireland||March 2010||Phase 2|
|NCT00528268||Completed||Drug: Sodium phenylbutyrate (NaPB)||Spinal Muscular Atrophy||University of Utah|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)||July 2007||Phase 1|Phase 2|
|NCT00107770||Completed||Drug: sodium phenylbutyrate||Amyotrophic Lateral Sclerosis||US Department of Veterans Affairs|Muscular Dystrophy Association|VA Office of Research and Development||April 2005||Phase 1|Phase 2|
|NCT00005639||Completed||Drug: Azacitidine Injection|Drug: sodium phenylbutyrate||Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor Protocol Specific||Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI)||March 2000||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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