C2β Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1489 PIK-93

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.

Pan C2β, IC50: 140 nM
S2636 A66

A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms.

Pan C2β, IC50: 462 nM
S1065 Pictilisib (GDC-0941)

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.

Pan C2β, IC50: 0.67 μM
S2699 CH5132799

CH5132799 inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.

Pan C2β, IC50: 5.3 μM