Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.

Amino-acid Sequence

CAS No. 1334237-71-6

Purity & Quality Control

Batch: P111001 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.78%

99.78

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (92.19 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description

Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.

Targets

CaSR

References
[1] Subramanian R, et al. Drug Metab Dispos. 2016 Aug;44(8):1319-31.

References

[1] Subramanian R, et al. Drug Metab Dispos. 2016 Aug;44(8):1319-31.

Product Information

Molecular Formula:	C₃₈H₇₄ClN₂₁O₁₀S₂
Molecular Weight:	1084.71
CAS No.:	1334237-71-6
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)