research use only

Degarelix acetate

Cat.No.P1094

Degarelix acetate (ASP-3550 acetate) is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) antagonist.

Amino-acid Sequence

CAS No. 934016-19-0

Quality Control

Batch: Purity: 99.94%

99.94

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 33 mg/mL ；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 33 mg/mL

Ethanol : Insoluble

In vivo Batch: Add solvents to the product individually and in order.					In vivo Formulation Calculator
	Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.	In vivo Formulation Calculator
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	5mg/ml (3.06mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.5mg/ml (0.31mM)	Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Description	Degarelix acetate (ASP-3550 acetate) is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) antagonist.

In Vivo
In vivo	Degarelix acetate is a member of a new class of long-acting gonadotropin-releasing hormone (GnRH) antagonists, possessing a long duration of luteinizing hormone (LH) and testosterone suppression.
Animal Research	Animal Models	castrated male rat model
	Dosages	50 μg
	Administration	--

References
https://pubmed.ncbi.nlm.nih.gov/11907162/ https://pubmed.ncbi.nlm.nih.gov/11462984/

Molecular Formula	C₈₂H₁₀₃ClN₁₈O₁₆.C₂H₄O₂
Molecular Weight	1632.26(free base)
CAS No.	934016-19-0
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)