Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

Amino-acid Sequence

CAS No. 1024828-77-0

Purity & Quality Control

Batch: P115101 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.69%

99.69

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (147.09 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description

Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

Targets

kappa opioid receptor

References
[1] Fishbane S, et al. Kidney Int Rep. 2020 Jan 28;5(5):600-610. [2] Fishbane S, et al. N Engl J Med. 2020 Jan 16;382(3):222-232.

References

Product Information

Molecular Formula:	C₃₆H₅₃N₇O₆
Molecular Weight:	679.85
CAS No.:	1024828-77-0
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)