TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.

Amino-acid Sequence

CAS No. 36951-72-1

Purity & Quality Control

Batch: P120201 Water] 50 mg/mL] false] ] ] false] ] ] false Purity: 98.73%

98.73

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

Water : 50 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description

TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.

Targets

G-quadruplex

IGF-1

telomerase

References
[1] Hongbo Chen, et al. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38. [2] Jun Fujimori, et al. J Orthop Res. 2011 Nov;29(11):1707-11.

References

Product Information

Molecular Formula:	C₇₂H₆₆N₈O₁₂S₄
Molecular Weight:	1363.6
CAS No.:	36951-72-1
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Purity (by HPLC):	0.9873
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)