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gp91ds-tat

Cat.No.P1213

gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.

Amino-acid Sequence

gp91ds-tat Amino-acid Sequence

CAS No.

Selleck's gp91ds-tat Has Been Cited by 1 Publication

Quality Control

Batch: P121301 Water] 49 mg/mL] false] ] ] false] ] ] false Purity: 99.95%
99.95

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

Water : 49 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.
Targets/IC50/Ki
NADPH oxidase

In vitro
In vitro

Gp91ds-tat, an inhibitor of NOX (NADPH oxidase) 2, can prevented high extracellular glucose (Hi-Glu)/Thiamet G (ThmG)-induced ROS generation.

In Vivo
In vivo

Gp91ds-tat can attenuate cerebral I/R injury in a rat model of middle cerebral artery occlusion (MCAO) through reducing ROS levels, inhibiting neuronal apoptosis and degeneration, and alleviating BBB damage.
Animal Research Animal Models middle cerebral artery occlusion (MCAO) model rats
Dosages 100 ng/kg
Administration infused into the ventricle

References
  • https://pubmed.ncbi.nlm.nih.gov/12861025/
  • https://pubmed.ncbi.nlm.nih.gov/32134364/
  • https://pubmed.ncbi.nlm.nih.gov/31407062/

Product Information

Molecular Formula

C109H202N52O25S1
Molecular Weight 2673.3
Appearance White Powder
Peptide Content (by %N) ≥80%
Single Impurity (by HPLC) ≤1.0%
Assay (By Anhydrous, Acetic Acid-free) 95.0~105.0%
MS Consistent
Packing plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt)		 3 years-20°C powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)