PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Amino-acid Sequence

CAS No. 514814-49-4（free base)

Batch: Purity: 99.47%

99.47

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (119.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 50 mg/mL

In vivo
Batch:

Add solvents to the product individually and in order.

Description

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Targets

C5a receptor

31 nM

In Vivo
In vivo	In Tg2576 mice, PMX205 treatment decreases both total amyloid deposits and fibrillar amyloid plaques and results in less reactive glia surrounding fibrillar amyloid plaques. PMX205 treatment causes significant decreases in hyperphosphorylated tau as well as fibrillar plaques in the 3xTg mouse model.^[2]

References
[1] Vinod Kumar, et al. ACS Omega . 2020 Jan 30;5(5):2345-2354. [2] Maria I Fonseca, et al. J Immunol. 2009 Jul 15;183(2):1375-83.

References

Molecular Formula:	C₄₅H₆₂N₁₀O₆
Molecular Weight:	839.04
CAS No.:	514814-49-4（free base)
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)