research use only

PMX 205 acetate

Cat.No.P1208

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Amino-acid Sequence

CAS No. 514814-49-4（free base)

Selleck's PMX 205 acetate Has Been Cited by 2 Publications

Quality Control

Batch: Purity: 99.47%

99.47

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL (119.18 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : 50 mg/mL

In vivo Batch: Add solvents to the product individually and in order.					In vivo Formulation Calculator
	Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.	In vivo Formulation Calculator
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	5.000mg/ml (5.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	16.000mg/ml (19.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 320 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Description	PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.
Targets/IC₅₀/Ki	C5a receptor

In Vivo
In vivo	In Tg2576 mice, PMX205 treatment decreases both total amyloid deposits and fibrillar amyloid plaques and results in less reactive glia surrounding fibrillar amyloid plaques. PMX205 treatment causes significant decreases in hyperphosphorylated tau as well as fibrillar plaques in the 3xTg mouse model.

References
https://pubmed.ncbi.nlm.nih.gov/32064396/ https://pubmed.ncbi.nlm.nih.gov/19561098/

Molecular Formula	C₄₅H₆₂N₁₀O₆
Molecular Weight	839.04
CAS No.	514814-49-4（free base)
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)