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Etanercept

Cat.No.P1240

Etanercept, a dimeric fusion protein, functions as an inhibitor of TNF by binding to TNF. It competitively blocks the attachment of both TNF-α and TNF-β to their cell surface receptors, thereby neutralizing TNF's biological activity. Etanercept has proven effectiveness in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

Amino-acid Sequence

CAS No. 185243-69-0

Quality Control

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vivo
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Biological Activity

Description	Etanercept, a dimeric fusion protein, functions as an inhibitor of TNF by binding to TNF. It competitively blocks the attachment of both TNF-α and TNF-β to their cell surface receptors, thereby neutralizing TNF's biological activity. Etanercept has proven effectiveness in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
Targets/IC₅₀/Ki	TNF

References
https://pubmed.ncbi.nlm.nih.gov/12894133/ https://pubmed.ncbi.nlm.nih.gov/10090426/

References

https://pubmed.ncbi.nlm.nih.gov/12894133/
https://pubmed.ncbi.nlm.nih.gov/10090426/

Product Information

CAS No.	185243-69-0
Storage (From the date of receipt)	2 years -20°C liquid
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)