research use only

Linaclotide

Cat.No.P1109

Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.

Amino-acid Sequence

Linaclotide Amino-acid Sequence

CAS No. 851199-59-2

Quality Control

Batch: P110901 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.75%

99.75

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL (65.49 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.

References

https://pubmed.ncbi.nlm.nih.gov/20307554/

Product Information

Molecular Formula	C₅₉H₇₉N₁₅O₂₁S₆
Molecular Weight	1526.75
CAS No.	851199-59-2
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)