Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.

Amino-acid Sequence

CAS No. 851199-59-2

Purity & Quality Control

Batch: P110901 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.75%

99.75

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (65.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.

References
[1] Bryant AP, et al. Life Sci. 2010 May 8;86(19-20):760-5.

References

[1] Bryant AP, et al. Life Sci. 2010 May 8;86(19-20):760-5.

Product Information

Molecular Formula:	C₅₉H₇₉N₁₅O₂₁S₆
Molecular Weight:	1526.75
CAS No.:	851199-59-2
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)