CDK8 Selective Inhibitors | Modulators

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S1058	BI-1347	BI-1347 is a small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.	Selective	CDK8, IC50: 1.1 nM
S8387	MSC2530818	MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.	Selective	CDK8, IC50: 2.6 nM
S0771	BRD6989	BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA).	Pan
S8903	AS2863619	AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in T_conv cells.	Pan	CDK8, IC50: 0.6099 nM
S8840	SEL120 (SEL120-34A) hydrochloride	SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.	Pan	CDK8, IC50: 4.4 nM
S7511	LY2857785	LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50=0.011 μM) and also inhibits other transcription kinases CDK8(IC50=0.016 μM) and CDK7 (IC50=0.246 μM).	Pan	CDK8, IC50: 0.016 μM
S8520	Senexin A	Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.	Pan	CDK8, Kd: 0.83 μM
S7981	CCT251545	CCT251545 is a potent, orally bioavailable inhibitor of WNT signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.	Pan