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LDC000067

Catalog No.S7461 Synonyms: LDC067

For research use only.

LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.

CAS No. 1073485-20-7

Selleck's LDC000067 has been cited by 36 publications

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CDK Signaling Pathway Map

Biological Activity

Description

LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.

Features

CDK9-selective inhibitor.

Targets

CDK9 ^[1] (Cell-free assay)	CDK2 ^[1] (Cell-free assay)
44 nM	2.441 μM

In vitro

LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo RNA synthesis of cellular genes.^[1]

Assay

Methods	Test Index	PMID

Western blot

CDK9 / RNAPII / p-RNAPII / MCL-1 / BIRC5

30579871

Protocol (from reference)

References	[1] Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.

References

[1] Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	370.43
Formula	C₁₈H₁₈N₄O₃S
CAS No.	1073485-20-7
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N

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In vivo Formulation Calculator (Clear solution)

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Tech Support

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