LDC000067

Catalog No.S7461 Synonyms: LDC067

For research use only.

LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.

LDC000067 Chemical Structure

CAS No. 1073485-20-7

Selleck's LDC000067 has been cited by 36 publications

Purity & Quality Control

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Biological Activity

Description LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.
Features CDK9-selective inhibitor.
Targets
CDK9 [1]
(Cell-free assay)
CDK2 [1]
(Cell-free assay)
44 nM 2.441 μM
In vitro

LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo RNA synthesis of cellular genes.[1]

Assay
Methods Test Index PMID
Western blot CDK9 / RNAPII / p-RNAPII / MCL-1 / BIRC5 30579871

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 370.43
Formula

C18H18N4O3S

CAS No. 1073485-20-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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