Duvelisib (IPI-145)

For research use only.

Catalog No.S7028 Synonyms: INK1197

30 publications

Duvelisib (IPI-145) Chemical Structure

CAS No. 1201438-56-3

Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.

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Selleck's Duvelisib (IPI-145) has been cited by 30 publications

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Biological Activity

Description Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.
PI3Kδ [1]
(Cell-free assay)
PI3Kβ [1]
(Cell-free assay)
PI3Kγ [1]
(Cell-free assay)
23 pM(Ki) 1564 pM(Ki) 243 pM(Ki)
In vitro

IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat NHnNcZVRem:uaX\ldoF1cW:wIHHzd4F6 NIr6bpU{KGSjeYO= NXfFdIxGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NU46KM7ebR?= M1O3elI4Pzd2MUK3
MOLT4 NInVb|NRem:uaX\ldoF1cW:wIHHzd4F6 NV7DO2l[OyCmYYnz MlruRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zUOEBk\WyuczDh[pRmeiB|IHThfZMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygTWM2OD1{LkOg{txO MVeyO|c4PDF{Nx?=
MV4-11 M{LjOnBzd2yrZnXyZZRqd25iYYPzZZk> MlG4N{Bl[Xm| NEjEbpNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{Bi\nSncjCzJIRigXNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3ME20MlQh|ryP Mn74Nlc4PzRzMke=
MOLM14 NYHqOGRHWHKxbHnm[ZJifGmxbjDhd5NigQ>? NGD4W3Q{KGSjeYO= NX\2XXY{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTRiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NU4zKM7:TR?= M1K4TVI4Pzd2MUK3
Loucy NEfOfGpRem:uaX\ldoF1cW:wIHHzd4F6 NHnKemU{KGSjeYO= MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyxdXP5JINmdGy|IHHmeIVzKDNiZHH5d{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxRTBwOUig{txO NWToc5RGOjd5N{SxNlc>
JURKAT NVPV[HJoTnWwY4Tpc44h[XO|YYm= NUfVblBlOC5zLDCxMlAtKGGwZDC5MlAh|ryP NWfLbVdKUVCLMUS1JJdieyCjYnzlJJRwKGmwaHnibZQhSWu2IHHu[EBUPiCyaH;zdIhwenmuYYTpc44h[W6mIH3v[IV{fGy7IHHm[oVkfGWmIHfyc5d1cCCrbjDKWXJMSVR? NYf4Z2pmOzB7N{CyOlM>
MOLT3 NViwendkTnWwY4Tpc44h[XO|YYm= Mk\yNE4yNCBzLkCsJIFv\CB7LkCg{txO NVnHTJlSUVCLMUS1JJdieyCjYnzlJJRwKGmwaHnibZQhSWu2IHHu[EBUPiCyaH;zdIhwenmuYYTpc44h[nW2IHLhdoVtgSCjZn\lZ5Rm\CC2aHWg[5Jwf3SqIH;mJG1QVFR|IGStRWxN M{nkcFMxQTdyMk[z
Raji32 NWfq[49{TnWwY4Tpc44h[XO|YYm= NXfyR5N5OSEQvF2= Mono[YZn\WO2aY\lcJkhcW2yYXny[YQhfGinIIDoc5NxcG:{eXzheIlwdiCxZjDBb5Q> M2Hnb|MxPTh2MkW0
Ramos460 M3TKXmZ2dmO2aX;uJIF{e2G7 Mlm2NUDPxE1? M3ezXYVn\mWldHn2[Yx6KGmvcHHpdoVlKHSqZTDwbI9{eGixconsZZRqd25ib3[gRYt1 Mn7vN|A2QDR{NUS=
HBL-1 MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7SXW9IUTVyPUWuN{DPxE1? NUXUbYI6OzByNke3O|E>
OCI-Ly3 MmfxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjhSmdMT0l3ME2zMlch|ryP Ml65N|AxPjd5N{G=
U-2932 NHPUeVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYXxdnFMT0l3ME2xMlgh|ryP NFzjeYc{ODB4N{e3NS=>
Farage NIjWO|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3HFV2dKPTB;MD6wOEDPxE1? Ml;1N|AxPjd5N{G=
SU-DHL-10 NXXheY1yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX;HTVUxRTJwNDFOwG0> M1rJOlMxODZ5N{ex
SU-DHL-4 M33zfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2LlOmdKPTB;MD6yJO69VQ>? M{LVe|MxODZ5N{ex
Karpas-422 MknFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGj5NZhIUTVyPUCuNUDPxE1? M3i5T|MxODZ5N{ex
DOHH-2 NIKwR4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlz1S2k2OD1yLkC1JO69VQ>? NF7Ecm0{ODB4N{e3NS=>
WSU-NHL NWKwd4NiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mni5S2k2OD1yLkCwPEDPxE1? NHfYOmI{ODB4N{e3NS=>
Jeko-1 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3fpc2dKPTB;MT6zJO69VQ>? M4TrNFMxODZ5N{ex
Mino M2[0Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEXiSphIUTVyPUOuOEDPxE1? MnryN|AxPjd5N{G=
NCI-H929 NVT5RZdmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mmr6S2k2OD1zIN88US=> NILlS5k{ODB4N{e3NS=>
HH MmLRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorSS2k2OD1yLkCxJO69VQ>? MV:zNFA3Pzd5MR?=
BJAB MVPD[YxtKH[rYXLpcIl1gSCjc4PhfS=> NVn4copvOC5zLDCxMEA2KM7:TR?= NXi0NXpKPDhiYX7kJFczKGh? MVTpcohq[mm2ZXSgZ4VtdCCpcn;3eIg> MoH1Nlk2OjJ{N{i=
LCL MVXD[YxtKH[rYXLpcIl1gSCjc4PhfS=> M2nVXVAvOSxiMTygOUDPxE1? Ml60OFgh[W6mIEeyJIg> MXrpcohq[mm2ZXSgZ4VtdCCpcn;3eIg> NUfhUlh7Ojl3MkKyO|g>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
p-AKT / AKT / p-MAPK / MAPK ; 

PubMed: 27174919     

AML cell lines and primary AML blasts were treated with increasing doses of IPI-145 (nM) and cultured for 4 hours. Whole cell extracts were prepared and Western blot analysis was conducted for pAKT, pMAPK, and total AKT and MAPK protein levels.

PI3Kγ / PI3Kδ ; 

PubMed: 29522278     

Effects of duvelisib on the PI3K/Akt pathway in B and T cell lines. EBV-negative B cell lines [BJAB and Akata (-)], EBV-positive B cell lines [Akata (+), Mutu I, LCL, Raji, and P3HR1], and EBV-negative T cell line (Jurkat) were treated without (-) or with 1 or 5 μmol/L duvelisib for 48 h. Cell lysates were then immunoblotted for the indicated proteins involved in PI3K/Akt signaling.

27174919 29522278
In vivo IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng•h/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model. [1]


Solubility (25°C)

In vitro DMSO 83 mg/mL (199.1 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 416.86


CAS No. 1201438-56-3
Storage powder
in solvent
Synonyms INK1197
Smiles CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02307461 Completed Drug: IPI-145 (duvelisib)|Drug: IPI-145 Healthy Verastem Inc. November 2014 Phase 1
NCT02095587 Completed Drug: IPI-145 Hepatic Impairment Verastem Inc. March 2014 Phase 1
NCT01947777 Completed Drug: IPI-145|Drug: Rifampin Healthy Verastem Inc. October 2013 Phase 1
NCT01925911 Completed Drug: IPI-145|Drug: Midazolam Healthy Verastem Inc. August 2013 Phase 1
NCT01836861 Completed Drug: IPI-145 Healthy Verastem Inc. March 2013 Phase 1
NCT01549106 Completed Drug: IPI-145|Drug: Placebo Healthy Volunteers Verastem Inc. August 2011 Phase 1

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Frequently Asked Questions

  • Question 1:

    Whether IPI-145 S7028 is mixture of two chiral forms, if not, which form is it?

  • Answer:

    S7028 IPI-145 is S form.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID