Duvelisib (IPI-145)

Catalog No.S7028 Synonyms: INK1197

For research use only.

Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.

Duvelisib (IPI-145) Chemical Structure

CAS No. 1201438-56-3

Selleck's Duvelisib (IPI-145) has been cited by 36 publications

Purity & Quality Control

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Biological Activity

Description Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.
Targets
PI3Kδ [1]
(Cell-free assay)
PI3Kβ [1]
(Cell-free assay)
PI3Kγ [1]
(Cell-free assay)
23 pM(Ki) 1564 pM(Ki) 243 pM(Ki)
In vitro

IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat NHT4bJFRem:uaX\ldoF1cW:wIHHzd4F6 MUOzJIRigXN? NYHncmZJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDKeZJs[XRiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NU46KM7ebR?= NFvm[|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e3OFEzPyd-Mke3O|QyOjd:L3G+
MOLT4 MVjQdo9tcW[ncnH0bY9vKGG|c3H5 NIj3PI0{KGSjeYO= NEHoNFBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3PUHQ1KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyPUKuN{DPxE1? MnnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{SxNlcoRjJ5N{e0NVI4RC:jPh?=
MV4-11 NUX0dZZYWHKxbHnm[ZJifGmxbjDhd5NigQ>? MmHSN{Bl[Xm| M3HxXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyPUSuOEDPxE1? M2O2WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{e0NVI4Lz5{N{e3OFEzPzxxYU6=
MOLM14 NIDVT|ZRem:uaX\ldoF1cW:wIHHzd4F6 NHWyO3g{KGSjeYO= NX7W[JZkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTRiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NU4zKM7:TR?= MoPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5N{SxNlcoRjJ5N{e0NVI4RC:jPh?=
Loucy M{Lxb3Bzd2yrZnXyZZRqd25iYYPzZZk> M2SxbFMh\GG7cx?= MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyxdXP5JINmdGy|IHHmeIVzKDNiZHH5d{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxRTBwOUig{txO NWTOeY12RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3O|QyOjdpPkK3O|c1OTJ5PD;hQi=>
JURKAT Mo[1SpVv[3Srb36gZZN{[Xl? NV36TnB5OC5zLDCxMlAtKGGwZDC5MlAh|ryP M1HDXmlRUTF2NTD3ZZMh[WKuZTD0c{BqdmirYnn0JGFsfCCjbnSgV|YheGixc4Doc5J6dGG2aX;uJIFv\CCvb3Tld5RtgSCjZn\lZ5Rm\CCpcn;3eIghcW5iSmXST2FV NGXi[3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm3NFI3Oyd-M{C5O|AzPjN:L3G+
MOLT3 NHHmeXhHfW6ldHnvckBie3OjeR?= NGD3NFIxNjFuIEGuNEwh[W6mIEmuNEDPxE1? Mli4TXBKOTR3IIfhd{Bi[mynIITvJIlvcGmkaYSgRYt1KGGwZDDTOkBxcG:|cHjvdplt[XSrb36gZpV1KGKjcnXsfUBi\m[nY4Tl[EB1cGViZ4Lve5RpKG:oIF3PUHQ{KFRvQVzM MlnIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7N{CyOlMoRjNyOUewNlY{RC:jPh?=
Raji32 NYrIflZ7TnWwY4Tpc44h[XO|YYm= MYOxJO69VQ>? MkHI[YZn\WO2aY\lcJkhcW2yYXny[YQhfGinIIDoc5NxcG:{eXzheIlwdiCxZjDBb5Q> NUjjTJg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C1PFQzPTRpPkOwOVg1OjV2PD;hQi=>
Ramos460 M2rLOmZ2dmO2aX;uJIF{e2G7 MnnRNUDPxE1? M4jQVIVn\mWldHn2[Yx6KGmvcHHpdoVlKHSqZTDwbI9{eGixconsZZRqd25ib3[gRYt1 MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODV6NEK1OEc,OzB3OESyOVQ9N2F-
HBL-1 MnHzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLHTVUxRTVwMzFOwG0> M4\oe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3O|cyLz5|MEC2O|c4OTxxYU6=
OCI-Ly3 NIH3blNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmXHS2k2OD1|Lkeg{txO NEf5T2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC2O|c4OSd-M{CwOlc4PzF:L3G+
TMD-8 MnmxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX3HTVUxRTBwMECwOUDPxE1? MljZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNke3O|EoRjNyME[3O|cyRC:jPh?=
U-2932 NIi2Om5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4S3T2dKPTB;MT64JO69VQ>? M3zWUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3O|cyLz5|MEC2O|c4OTxxYU6=
Farage NHfXVpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYLrPGsyT0l3ME2wMlA1KM7:TR?= M{\IdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3O|cyLz5|MEC2O|c4OTxxYU6=
SU-DHL-10 NEPsTG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3T6ZmdKPTB;Mj60JO69VQ>? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB4N{e3NUc,OzByNke3O|E9N2F-
SU-DHL-4 M2jPSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3yd4tYT0l3ME2wMlIh|ryP NHjpRYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC2O|c4OSd-M{CwOlc4PzF:L3G+
Karpas-422 NGfue2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPHTVUxRTBwMTFOwG0> MmHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNke3O|EoRjNyME[3O|cyRC:jPh?=
DOHH-2 NUL2cGVuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTHTVUxRTBwMEWg{txO NX3XTWR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOlc4PzFpPkOwNFY4PzdzPD;hQi=>
WSU-NHL MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrHTVUxRTBwMEC4JO69VQ>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB4N{e3NUc,OzByNke3O|E9N2F-
Jeko-1 NXjHd|A4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2\WVWdKPTB;MT6zJO69VQ>? MlTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNke3O|EoRjNyME[3O|cyRC:jPh?=
Mino M{i0SWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\HTVUxRTNwNDFOwG0> M{n3TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyME[3O|cyLz5|MEC2O|c4OTxxYU6=
NCI-H929 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\HTVUxRTFizszN NV\xWVhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOlc4PzFpPkOwNFY4PzdzPD;hQi=>
HH M4nzXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPIOYpIUTVyPUCuNFEh|ryP MkjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNke3O|EoRjNyME[3O|cyRC:jPh?=
BJAB M3niR2NmdGxidnnhZoltcXS7IHHzd4F6 NXzJOGF3OC5zLDCxMEA2KM7:TR?= NF\EVWY1QCCjbnSgO|IhcA>? MVvpcohq[mm2ZXSgZ4VtdCCpcn;3eIg> NVW0ZVZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NlIzPzhpPkK5OVIzOjd6PD;hQi=>
LCL MX\D[YxtKH[rYXLpcIl1gSCjc4PhfS=> MlHMNE4yNCBzLDC1JO69VQ>? NYPD[4dFPDhiYX7kJFczKGh? MXPpcohq[mm2ZXSgZ4VtdCCpcn;3eIg> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV{MkK3PEc,Ojl3MkKyO|g9N2F-
insect cells MoTGSpVv[3Srb36gZZN{[Xl? NXrtc2NYPSCvaX7z M1zhSWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iQz30[ZJucW6jbDDIbZM3NXSjZ3fl[EBxOTFyZ3HtcYEh\XiycnXzd4VlKGmwIHnud4VkfCClZXzsd{B2e2mwZzDwbI9{eGijdHnkfYxqdm:|aYTvcEBieyC|dXLzeJJifGViaX6gdJJme2WwY3Wgc4Yh\2GvbXGtN|JRNUGWUDDh[pRmeiB3IH3pcpMh[nlidHjpckBt[XmncjDjbJJwdWG2b3fyZZBpcWNibXX0bI9lNCCLQ{WwJF0hOC5zIN88UU4> M1PHd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMxOzl3MEKvK|5EcEWPQly8M4E,
Sf21 NVX5TlNiTnWwY4Tpc44h[XO|YYm= NF:1XVA2KG2rboO= M1HqSWlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZM3NXSjZ3fl[EBz\WOxbXLpcoFvfCCodXzsMYxmdme2aDDoeY1idiCyMUGw[IVtfGFxdX70ZYdo\WRicnXjc41jcW6jboSg[pVtdCCuZX7neIgheDh3YXzwbIEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNnOjFiY3XscJMhfXOrbnegdIhwe3CqYYTp[JltcW6xc3n0c4wh[XNic4Xid5Rz[XSnIHnuJJBz\XOnbnPlJI9nKGejbX3hMVMzWC2DVGCgZYZ1\XJiNTDtbY5{KGK7IITobY4hdCxiSVO1NEA:KDBwMTFOwG0v NGDF[GI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{ODN7NUCyM{c,S2iHTVLMQE9iRg>?
splenic B MkDVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVmzNEBucW6| MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLhcIIw[yCvb4Xz[UB{eGynbnnjJGIh[2WubIOgdJJmcW6ldXLheIVlKG[xcjCzNEBucW6|IH\vcIxwf2WmIHL5JGxRWyCxcjDGLIFjLyl{IHTvcotmgSCjboTpMY1wfXOnIFnnUUBidmRicnXjc41jcW6jboSgcY92e2ViSVy0JJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBCdGGvYYKgRox2\SC{ZXT1Z5Rqd25iYYPzZZktKEWFNUCgQUAxNjFizszNMi=> NIrEN5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{ODN7NUCyM{c,S2iHTVLMQE9iRg>?
Sf21 NEiyO3lHfW6ldHnvckBie3OjeR?= MkPIOUBucW6| MlfMTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd|YufGGpZ3XkJJJm[2:vYnnuZY51KG[3bHytcIVv\3SqIHj1cYFvKHBzMUDi[ZRiN3WwdHHn[4VlKHKnY3;tZolv[W62IH\1cIwhdGWwZ4ToJJA5PWGucHjhJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcGG2aXT5cIlvd3OrdH;sJIF{KHO3YoP0doF1\SCrbjDwdoV{\W6lZTDv[kBo[W2vYT2zNnAuSVSSIHHmeIVzKDVibXnud{BjgSC2aHnuJIxiNCCLQ{WwJF0hOSEQvF2u NHr4[JU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{ODN7NUCyM{c,S2iHTVLMQE9iRg>?
Sf21 NWC1dI9[TnWwY4Tpc44h[XO|YYm= NUfFS45kPSCvaX7z NHrsVW1KdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{Pi22YXfn[YQhemWlb33ibY5idnRiZoXscE1t\W6pdHigbJVu[W5icEGxNIFteGijL4XueIFo\2WmIILlZ49u[mmwYX70JIZ2dGxibHXu[5RpKGi3bXHuJJA5PWGucHjhJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcGG2aXT5cIlvd3OrdH;sJIF{KHO3YoP0doF1\SCrbjDwdoV{\W6lZTDv[kBo[W2vYT2zNnAuSVSSIHHmeIVzKDVibXnud{BjgSBuIFnDOVAhRSBzMDFOwG0v MkHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|A{QTVyMj:nQmNpTU2ETEyvZV4>
Assay
Methods Test Index PMID
Western blot p-AKT / AKT / p-MAPK / MAPK ; PI3Kγ / PI3Kδ 27174919 29522278
In vivo IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng•h/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 83 mg/mL
(199.1 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 416.86
Formula

C22H17ClN6O

CAS No. 1201438-56-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02307461 Completed Drug: IPI-145 (duvelisib)|Drug: IPI-145 Healthy SecuraBio November 2014 Phase 1
NCT02095587 Completed Drug: IPI-145 Hepatic Impairment SecuraBio March 2014 Phase 1
NCT01947777 Completed Drug: IPI-145|Drug: Rifampin Healthy SecuraBio October 2013 Phase 1
NCT01925911 Completed Drug: IPI-145|Drug: Midazolam Healthy SecuraBio August 2013 Phase 1
NCT01836861 Completed Drug: IPI-145 Healthy SecuraBio March 2013 Phase 1
NCT01549106 Completed Drug: IPI-145|Drug: Placebo Healthy Volunteers SecuraBio August 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Whether IPI-145 S7028 is mixture of two chiral forms, if not, which form is it?

Answer:
S7028 IPI-145 is S form.

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