SIRT1 Selective Inhibitors | Activators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1541 EX 527 (Selisistat)

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.

Selective SIRT1, IC50: 38 nM
S1129 SRT1720

SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3.

Selective SIRT1, EC50: 0.16 μM
S4900 Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

Pan SIRT1, IC50: 21 μM
S2804 Sirtinol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively.

Pan SIRT1, IC50: 131 μM
S1396 Resveratrol

Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.