Catalog No.S8460

Salermide Chemical Structure

Molecular Weight(MW): 394.47

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

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Biological Activity

Description Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
SIRT1 [1] SIRT2 [1]
In vitro

Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CRO cells MmXrR5l1d3SxeHnjbZR6KGG|c3H5 NEXyUog4OiCq MonuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR3JQKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCFQ{WwQVYvPyEQvF2= NFr2WlkzOzF6OUm2Oy=>
CRC 1.1 cells M13xZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYq3NkBp MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDVmMhOS5zIHPlcIx{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDDR|UxRTlwNzFOwG0> MnjDNlMyQDl7Nke=
30PT cells NXzSUYs4S3m2b4TvfIlkcXS7IHHzd4F6 NX:5dFJEPzJiaB?= NYXjfpVQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOzCSVDDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubzDseY1qdmW|Y3XueEBie3OjeTygR2M2OD1|Nj61JO69VQ>? M2\OeFI{OTh7OU[3
30P cells M1joSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HITlczKGh? MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCzNHAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8hdHWvaX7ld4NmdnRiYYPzZZktKEOFNUC9OFEh|ryP MW[yN|E5QTl4Nx?=
MCF7 cells Ml7QVJJwdGmoZYLheIlwdiCjc4PhfS=> NV7OU2V7OzBizszN NIT6[mszPC15MjDo MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhOjRidH:gO|IhcHK| MXqyOFM1ODF4OR?=
U937 cells MV\GeY5kfGmxbjDhd5NigQ>? NU\re5hGPTBizszN M1jRdlQ2KGh? NITSXmNKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGW5N|ch[2WubIOgZZQhPTBidV2gZYZ1\XJiNEWgbJJ{KGK7IH\sc5ch[3m2b33leJJ6 MmD3NlMyQDl7Nke=
MOLT4 cells M4PpUHBzd2yrZnXyZZRqd25iYYPzZZk> NXPYSHlFOjVizszN MUeyOE04OiCq MmLyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zUOEBk\WyuczDheEAzPSC3TTDh[pRmeiB{NDD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6 Mn7ONlMyQDl7Nke=
MDA-MB-231 cells MX;Qdo9tcW[ncnH0bY9vKGG|c3H5 NGfOc|MzPSEQvF2= MlXLNlQuPzJiaB?= NGX3e2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYSgNlUhfU1iYX\0[ZIhOjRidH:gO|IhcHK|IHL5JG1VXCCjc4PhfS=> NUPrVG96OjNzOEm5Olc>
RKO cells M3u2b3Bzd2yrZnXyZZRqd25iYYPzZZk> NF7qe5YzPSEQvF2= NV7ac4l4OjRvN{KgbC=> M1iwZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUlvPJINmdGy|IHH0JFI2KHWPIHHmeIVzKDJ2IITvJFczKGi{czDifUBOXFRiYYPzZZk> NGnTe2wzOzF6OUm2Oy=>

... Click to View More Cell Line Experimental Data

In vivo Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1].


Cell Research:[1]
+ Expand
  • Cell lines: MOLT4, MDA-MB-231 and SW480 cancer cell lines
  • Concentrations: 0, 25, 50, 75 or 100 μM
  • Incubation Time: 24 h
  • Method: Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μm) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Athymic (BALB/c, nu/nu) female nude mice
  • Formulation: --
  • Dosages: 100 μl of 100 μM
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 78 mg/mL (197.73 mM)
Ethanol 7 mg/mL warmed (17.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 394.47


CAS No. 1105698-15-4
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID