Tenovin-1

For research use only.

Catalog No.S8000

2 publications

Tenovin-1 Chemical Structure

CAS No. 380315-80-0

Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 270 In stock
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Selleck's Tenovin-1 has been cited by 2 publications

1 Customer Review

  • The SIRT1 inhibitor (tenovin-1) partially blocked the protective effect of γ-man in L02 cells. The effect of tenovin-1 on expression and acetylation level of PGC-1α (B) in L02 cells treated with or without γ-man.

    Journal of Functional Foods, 2018, 40:544-553. Tenovin-1 purchased from Selleck.

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Biological Activity

Description Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
Targets
p53 [1]
()
Mdm2 [1]
()
DHODH [2]
()
In vitro

Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 cells NGrubFZHfW6ldHnvckBie3OjeR?= MoHGNVAh|ryP M1XWNVYhcA>? MmniTY5pcWKrdHnvckBw\iCVaYLUNUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOVMh\XiycnXzd4lwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHH0JFExKHWPIHHmeIVzKDZiaILzJIJ6KFenc4Tldo4h[myxdITpcoc> MVmyNlMxPDh2OB?=

... Click to View More Cell Line Experimental Data

In vivo

Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts. [1]

Protocol

Cell Research:

[1]

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  • Cell lines: HCT116, HCT116 p53−/−, EW36, BL2, NTera2D, NTera2D-DNp53, ARN8, NHDF, SKNH-pCMV and SKNSH-DNp53.
  • Concentrations: 10 μM
  • Incubation Time: 4 days
  • Method:

    Cell viability isdetermined by trypan blue exclusion, Giemsa staining, or MTT assays.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female SCID mice injected subcutaneously with ARN8 cells suspended in matrigel.
  • Dosages: 92.5 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (200.28 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
15% Captisol
For best results, use promptly after mixing.
15 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.48
Formula

C20H23N3O2S

CAS No. 380315-80-0
Storage powder
in solvent
Synonyms N/A
Smiles CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID