For research use only.

Catalog No.S8245 Synonyms: TM

1 publication

Thiomyristoyl Chemical Structure

Molecular Weight(MW): 581.85

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

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Selleck's Thiomyristoyl has been cited by 1 publication

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Biological Activity

Description Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
SIRT2 [1]
(Cell-free assay)
28 nM
In vitro

Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. In vitro, it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM[1].

In vivo The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice[1].


Cell Research:[1]
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  • Cell lines: breast cancer cell lines MCF-7
  • Concentrations: 1, 5, 10, 25, 50 μM
  • Incubation Time: 6 h
  • Method: Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft model
  • Dosages: 1.5 mg/50 μL (IP); 0.75 mg/50 μL (IT)
  • Administration: intraperitoneal (IP) or intra-tumor (IT) injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (171.86 mM)
Ethanol 100 mg/mL warmed (171.86 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 581.85


CAS No. 1429749-41-6
Storage powder
in solvent
Synonyms TM

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00424866 Not yet recruiting Drug: FGF-1|Drug: Placebo Peripheral Arterial Disease|Stenosis|Intermittent Claudication CardioVascular BioTherapeutics Inc. December 2020 Phase 1|Phase 2
NCT04397614 Recruiting Other: mHealth Assessments Sars-CoV2|Covid-19 University of Oklahoma July 2020 --
NCT04496310 Recruiting Procedure: Telemedicine Epilepsy|Epileptic Encephalopathy|Refractory Epilepsy Azienda Usl di Bologna July 9 2020 Not Applicable
NCT04381221 Not yet recruiting -- Leukemia Childhood|Solid Tumor Childhood Centre for Research and Technology Hellas|Saarland University|Brno University Hospital|Hannover Medical School June 2020 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID