Catalog No.S8245 Synonyms: TM
Molecular Weight(MW): 581.85
Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
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|Description||Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.|
Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. In vitro, it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM.
|In vivo||The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice.|
|In vitro||DMSO||100 mg/mL (171.86 mM)|
|Ethanol||100 mg/mL warmed (171.86 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03121469||Not yet recruiting||Localized Breast Cancer||Centre Antoine Lacassagne||June 8 2018||Not Applicable|
|NCT02840084||Recruiting||Capsular Contracture of Breast Grade III||Nina S. Naidu MD|Naidu Nina S. M.D.||April 7 2017||Not Applicable|
|NCT01543477||Active not recruiting||Renal Anemia|Pregnancy|Lactation||Pfizer|Hospira now a wholly owned subsidiary of Pfizer||July 7 2010||--|
|NCT03164863||Recruiting||Breast Cancer||Animated Dynamics Inc.||March 6 2017||--|
|NCT00967785||Recruiting||WHIMS|Neutrophil Disorder|Myelokathexis|Hypogammaglobulinemia||National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC)||August 6 2009||Phase 1|
|NCT02652260||Active not recruiting||HIV-1 Infection|CNS Toxicity||Merck Sharp & Dohme Corp.||March 4 2016||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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