UBCS039

Catalog No.S8909

For research use only.

UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

UBCS039 Chemical Structure

CAS No. 358721-70-7

Selleck's UBCS039 has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Targets
SIRT6 [1]
(Cell-free assay)
38 μM(EC50)
In vitro

UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.UBCS039 leads to autophagosome accumulation and induces autophagic flux in human cancer cells.UBCS039 also induces autophagy-associated cell death.[1]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: HeLa cells
  • Concentrations: 100 µM
  • Incubation Time: 24 h
  • Method:

    HeLa cells are treated with 100 µM UBCS039 for 24 h, harvested, washed in PBS 1× and stained for 30 min at 37 °C with dihydroethidium 50 µM dissolved in DMEM without fetal bovine serum.

Solubility (25°C)

In vitro

DMSO 49 mg/mL
(198.14 mM)
Ethanol 16 mg/mL
(64.7 mM)
Water Insoluble

Chemical Information

Molecular Weight 247.29
Formula

C16H13N3

CAS No. 358721-70-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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