TNF-α Selective Inhibitors
| Catalog No. | Product Name | Information | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S4902 | QNZ (EVP4593) | QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively. |
Selective | TNF-α, IC50: 7 nM |
| S1029 | Lenalidomide (CC-5013) | Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. |
Selective | TNF-α, IC50: 13 nM |
| S1567 | Pomalidomide | Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. |
Selective | TNF-α, IC50: 13 nM |
| S8037 | Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
Selective | RIP1, EC50: 490 nM |
| S1193 | Thalidomide | Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex. |
Selective |
