TNF-α Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S4902 QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.

Selective TNF-α, IC50: 7 nM
S1029 Lenalidomide (CC-5013)

Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Selective TNF-α, IC50: 13 nM
S1567 Pomalidomide

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM.

Selective TNF-α, IC50: 13 nM
S8037 Necrostatin-1

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

Selective RIP1, EC50: 490 nM
S1193 Thalidomide

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.

Selective