Home Apoptosis TNF-alpha antagonist R-7050 For research use only.

R-7050

R-7050 is a cell permeable TNF-α receptor antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.

R-7050 Chemical Structure

R-7050 Chemical Structure

CAS: 303997-35-5

Selleck's R-7050 has been cited by 7 publications

Purity & Quality Control

Batch: Purity: 99.55%
99.55

R-7050 Related Products

Signaling Pathway

TNF-alpha Signaling Pathways

TNF-alpha Signaling Pathway

Choose Selective TNF-alpha Inhibitors

Biological Activity

Description R-7050 is a cell permeable TNF-α receptor antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.
Targets
TNF-α [2] IL-1β [2]
0.63 μM(EC50) 1.45 μM(EC50)
In vitro
In vitro

R-7050 has a clear selectivity toward TNFα and to a slightly weaker extent toward the LPA receptor which belongs to a GPCR class over IL-1β, tyrosine kinase, or Fas receptor systems[2].
In Vivo
In vivo

R-7050 attenuates neurovascular injury after intracerebral hemorrhage (ICH) in mice, Up to 2h post-injury administration of R-7050 significantly reduced blood-brain barrier opening and attenuated edema development at 24h post-ICH. Neurological outcomes were also improved over the first three days after injury. In contrast, R-7050 did not reduce hematoma volume[1].
Animal Research Animal Models A mouse collagenase model of ICH (based on male CD-1 mice)
Dosages 6–18 mg/kg
Administration IP

Chemical Information & Solubility

Molecular Weight 380.77 Formula

C16H8ClF3N4S
CAS No. 303997-35-5 SDF --
Smiles C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 9 mg/mL ( (23.63 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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