ex229 (compound 991)

Catalog No.S8654

For research use only.

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

ex229 (compound 991) Chemical Structure

CAS No. 1219739-36-2

Selleck's ex229 (compound 991) has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.
Targets
AMPK [1]
In vitro

EX229 activates AMPK in incubated rat epitrochlearis skeletal muscle and incubation of rat skeletal muscle with ex229 increases glucose uptake. The stimulation of skeletal muscle glucose uptake by ex229 is PI3K/PKB-independent, while AMPK-dependent. ex229 increases fatty acid oxidation and glucose uptake in L6 myotubes[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf21 NVTEbpVTTnWwY4Tpc44h[XO|YYm= NIrrZ|g{OCCvaX7z MX\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIILlZ49u[mmwYX70JJBpd3OyaH;yfYxifGWmIFHNVGsh[2:vcHzlfEA4KGGucHjhNk9j\XSjMT;nZY1u[TFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOoMkGgZ4VtdHNiYYPz[ZN{\WRiYYOgdIhwe3Cqb4L5cIF1cW:wIH;mJFUuTkGPLXzhZoVt\WRiU1HNV{B{fWK|dILheIUheHKnaX7jeYJifGWmIH\vdkA{OCCvaX7zJIlvKHC{ZYPlcoNmKG:oIFHNVGsh[WO2aY\heI9zKG[xbHzve4UtKEWFNUC9NE4xODMQvF2= M3zueVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEO1OVY4Lz5{OUCzOVU3PzxxYU6=
Sf21 M4DWU2Z2dmO2aX;uJIF{e2G7 Mnv1N|AhdWmwcx?= NGXCe|lC[3SrdnH0bY9vKG:oIH\1cIwhdGWwZ4ToJIh2dWGwIILlZ49u[mmwYX70JGFOWEtiYXzwbIEyN2KndHGxM4didW2jMTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRic3[yNUBk\WyuczD1d4lv\yCVQV3TJJBmeHSrZHWgd5Vje3S{YYTlJIFnfGW{IEOwJI1qdnNiaX6gdJJme2WwY3Wgc4YhYzN|UG3BWHAh[nliVH;wR492dnRiYX7hcJl{cXNuIFXDOVA:OC5yMEROwG0> MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MkexNlUoRjJ5N{K3NVI2RC:jPh?=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 431.87
Formula

C24H1ClN3O3

CAS No. 1219739-36-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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