Ribociclib (LEE011)

For research use only. Not for use in humans.

Catalog No.S7440

35 publications

Ribociclib (LEE011) Chemical Structure

Molecular Weight(MW): 434.54

Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.

Size Price Stock Quantity  
USD 197 In stock
USD 297 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Ribociclib (LEE011) has been cited by 35 publications

Purity & Quality Control

Choose Selective CDK Inhibitors

Biological Activity

Description Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.
Features Orally bioavailable CDK4/6-selective inhibitor that has been tested in Phase III clinical trials for treatment of advanced breast cancer.
CDK4 [1]
(Cell-free assay)
CDK6 [1]
(Cell-free assay)
In vitro

LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
DFSP105 MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j5OlI1KGh? MXrHTVUxRTJ5NjDuUS=> M2HFOFI2QDV{MEW4
Myoblast NEjoVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13KZlczKGh? NV;4[25nUUN3ME2xNFM2KG6P NXn2cpZCOjV6MUCzO|U>
IMRS NVWzWnVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;0NYw4OiCq MYrJR|UxRTh5MzDuUS=> M3nqb|I2QDFyM{e1
SKNAS NHX4d|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPyO|IhcA>? M4\jRWlEPTExvK6xNFAxOCCwTR?= MVKyOVgyODN5NR?=
Rh28 NI\XNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK3NkBp NULzclFrUUN3ME24OFUhdk1? NYnid2dsOjV6MUCzO|U>
Rh41 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjzZoltPzJiaB?= NF\ibFFKSzVyPUexPFchdk1? MWWyOVgyODN5NR?=
CW9019 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml63O|IhcA>? MorOTWM2OD17OUGyJI5O Mn;nNlU5OTB|N{W=
Rh5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHGx[Y44OiCq MWHJR|Ux97zgMUCwNFAhdk1? NWXQUVAzOjV6MUCzO|U>
Rh30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULvR2xjPzJiaB?= M2jOeWlEPTExvK6xNFAxOCCwTR?= NFrLd4gzPThzMEO3OS=>
778 NYe3U5l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TaWlczKGh? MXnpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 MoLqNlUxOjh2Nkm=
449 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrxOWwxPzJiaB?= MVrpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 M1XqT|I2ODJ6NE[5
LP3 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nVclczKGh? M{Hu[4lvcGmkaYTzJINmdGxiZ4Lve5RpKGSxc3Wg[IVx\W6mZX70cJk> NELybpYzPTB{OES2PS=>
LP6 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq2dYg4OiCq MYjpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 MYeyOVAzQDR4OR?=
LP8 M{e5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHxVpM6PzJiaB?= NEPnSYFqdmirYnn0d{Bk\WyuIHfyc5d1cCCmb4PlJIRmeGWwZHXueIx6 MlvGNlUxOjh2Nkm=
LPS141 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TM[VczKGh? NVzsO4htcW6qaXLpeJMh[2WubDDndo94fGhiZH;z[UBl\XCnbnTlcpRtgQ>? M3W3OVI2ODJ6NE[5
778 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjhe4U{NjN|IN88US=> NEXKOHUzPCCq MXTk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[gZ4VtdHNiaX6gV{BxcGG|ZR?= NXfpTFRrOjVyMki0Olk>
449 M1HIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqzMlM{KM7:TR?= MY[yOEBp NF:0c4tl\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh[2WubIOgbY4hWyCyaHHz[S=> M4D6[lI2ODJ6NE[5
LP3 M2nTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LQ[lMvOzNizszN NGjDR4MzPCCq MVzk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[gZ4VtdHNiaX6gV{BxcGG|ZR?= MXuyOVAzQDR4OR?=
LP6 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTDN{4{OyEQvF2= NWq0UYRYOjRiaB?= MVrk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[gZ4VtdHNiaX6gV{BxcGG|ZR?= NEHYd4QzPTB{OES2PS=>
LP8 M360T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZN{4{OyEQvF2= NXvSToVtOjRiaB?= MY\k[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[gZ4VtdHNiaX6gV{BxcGG|ZR?= NEDEfoIzPTB{OES2PS=>
LPS141 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz1cXgyOy5|MzFOwG0> MnqxNlQhcA>? NWPpW4tR\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGOnbHzzJIlvKFNicHjhd4U> MmXiNlUxOjh2Nkm=
BE2C M4PhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rvVFI1KGh? MmO5SG1UVw>? M1vUdWlEPTB;MUO0JI5O Mki0NlQxPDVzN{m=
1643 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;5XVI1KGh? M{\ZcmROW09? NFnNPHhKSzVyPUG0O{BvVQ>? NEHYe24zPDB2NUG3PS=>
SKNSH NILBV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojWNlQhcA>? NHP0boZFVVOR NYmxfXlKUUN3ME2xOFghdk1? NHHh[5UzPDB2NUG3PS=>
KELLY M1LnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXZXJh5OjRiaB?= NFfSb3JFVVOR M1m0bmlEPTB;MkKwJI5O MW[yOFA1PTF5OR?=
CHP134 NGniV|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXPXIIzPCCq MkX1SG1UVw>? NVzsSWV{UUN3ME2yO|Mhdk1? NFewZnUzPDB2NUG3PS=>
NLF M{L2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnTc5J6OjRiaB?= NY\yVnh4TE2VTx?= Mk\PTWM2OD1|Mkigcm0> MlTLNlQxPDVzN{m=
LAN5 NI\qRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUeyOEBp MVnEUXNQ MlrTTWM2OD12Mkmgcm0> NH;rSlczPDB2NUG3PS=>
NB69 M3vlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml33NlQhcA>? M1fWUWROW09? NVfGXZhsUUN3ME23N|ghdk1? NYLuXWdVOjRyNEWxO|k>
NBSD M3\vc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD0NlQhcA>? NYHJV|Q5TE2VTx?= NF31PVFKSzVyPUG5NFAhdk1? NWnySolrOjRyNEWxO|k>
SKNF1 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmyOEBp NE\X[|JFVVOR M4rYN2lEPTB;M{WwNEBvVQ>? NWnSb4FwOjRyNEWxO|k>
EBC1 M{fReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LUblI1KGh? NVXz[pdsTE2VTx?= NV7TV4Q4UUN3ME22OFAxKG6P NVjidoR5OjRyNEWxO|k>
NB16 NY\5eW1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HNfFI1KGh? Mn7ESG1UVw>? M17LWGlEPTExvK6xNFAxOCCwTR?= NXvvSWp5OjRyNEWxO|k>
RPE1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHpfWwzPCCq M3u4d2ROW09? NHPhSFBKSzVy78{eNVAxODBibl2= MWCyOFA1PTF5OR?=

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
pRb(S807) / Rb / p53 / Cyclin E / Cyclin D1 / CDK4 / CDK6 / p27 / p21 / PARP; 

PubMed: 29789630     

Effect of ribociclib on pRB and G1 cell cycle regulating protein expressions in C666-1 and HK1 cells. Cells were treated with ribociclib in 2 concentrations, one of them near their corresponding IC50, for 24 and 48 hours. Phosphorylation of Rb in all cell䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ ⟸෕Ð㺣痖⟸෕€𢡄⟼෕€䀷痗⟼෕౴⟼෕

Growth inhibition assay
Cell viability ; 

PubMed: 26390342     

Effects of palbociclib and ribociclib on viability of H157, H2170, H520 and H596 cells after 72 hours of drug treatment and IC50 values for inhibition of cell viability.

In vivo LEE011 (200 mg/kg daily, p.o.) significantly causes tumor growth delay in mice harboring the BE2C or 1643 xenografts with no weight loss or other signs of toxicity. [1]


Cell Research:


- Collapse
  • Cell lines: BE2C, IMR5, 1643, SY5Y, CHP134, SKNSH, NGP, KELLY, LAN5, NLF, NB69, SKNDZ, NBSD, NBLS, SKNFI, EBC1, SKNAS, NB16, RPE1 cell lines.
  • Concentrations: 10 μM
  • Incubation Time: ~100 hours
  • Method:

    A panel of neuroblastoma cell lines, selected based upon prior demonstration of substrate adherent growth, is plated in triplicate on the Xcelligence Real-Time Cell Electronic Sensing system and treated 24 hours later with a four-log dose range of inhibitor or with a dimethyl sulfoxide (DMSO) control. Cell indexes are monitored continuously for ~100 hours, and IC50 values are determined as follows: growth curves are generated by plotting the cell index as a function of time and are normalized to the cell index at the time of treatment for a baseline cell index of 1. The area under the normalized growth curve from the time of treatment to 96 hours posttreatment is then calculated using a baseline area of 1 (the cell index at the time of treatment). Areas are normalized to the DMSO control, and the resulting data are analyzed using a nonlinear log inhibitor versus normalized response function. All experiments are repeated at least once.

    (Only for Reference)
Animal Research:


- Collapse
  • Animal Models: Mice bearing BE2C, NB-1643, or EBC1 xenografts.
  • Formulation: 0.5% methylcellulose
  • Dosages: ~200 mg/kg daily
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 7 mg/mL (16.1 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.54


CAS No. 1211441-98-3
Storage powder
in solvent
Synonyms N/A
Smiles CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03834740 Recruiting Drug: Ribociclib|Drug: Everolimus Glioblastoma Multiforme|Glioma of Brain St. Joseph''s Hospital and Medical Center Phoenix|Ivy Brain Tumor Center|Barrow Neurological Institute December 21 2018 Early Phase 1
NCT03701334 Recruiting Drug: Ribociclib|Other: Endocrine Therapy Early Breast Cancer Novartis Pharmaceuticals|Translational Research in Oncology|Novartis December 7 2018 Phase 3
NCT03613220 Recruiting Drug: ribociclib|Drug: letrozole HR+ HER2 Breast Cancer Novartis Pharmaceuticals|Novartis December 28 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

CDK Signaling Pathway Map

Related CDK Products

Tags: buy Ribociclib (LEE011) | Ribociclib (LEE011) supplier | purchase Ribociclib (LEE011) | Ribociclib (LEE011) cost | Ribociclib (LEE011) manufacturer | order Ribociclib (LEE011) | Ribociclib (LEE011) distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID