APTSTAT3-9R

For research use only.

Catalog No.S8197

3 publications

APTSTAT3-9R Chemical Structure

CAS No. no CAS

APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.

Selleck's APTSTAT3-9R has been cited by 3 publications

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Biological Activity

Description APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.
Targets
STAT3 [1]
(In A549 cells)
In vitro

APTSTAT3-9R effectively inhibited phosphorylation of STAT3 but did not affect the level of AKT phosphorylation and it suppresses cell viability and proliferation of cancer cells[1].

In vivo APTSTAT3-9R could effectively suppress tumor growth in the in vivo allograft and xenograft tumor models by inhibiting STAT3 phosphorylation[1].

Protocol

Cell Research:[1]
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  • Cell lines: A549 cells
  • Concentrations: 0-100 μmol/L
  • Incubation Time: 12 h
  • Method: Cells are plated in a 96-well plate (5,000 cells/well) and incubated for 12 hours. After incubation the cells are treated with nine-arginine (9R), APTSTAT3-9R, and APRscr-9R for 12 hours. After 12 hours incubation, 20 μL MTT (5 mg/mL) is added to each well. After 4 hours, 100 μL dimethyl sulfoxide is added to each well, and absorbance is measured at 570 nm using a Spectra Macplus microplate reader
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Human lung carcinoma xenograft model(by subcutaneous implantation of A549 cancer cells into female BALB/c nude mice)
  • Dosages: 8 mg/kg
  • Administration: intratumoral injection
    (Only for Reference)

Solubility (25°C)

In vitro Water 98 mg/mL (19.8 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 4947.51
Formula

C223H330N80O51

CAS No. no CAS
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID