Homoharringtonine

Catalog No.s9015 Synonyms: Omacetaxine mepesuccinate

Homoharringtonine Chemical Structure

Molecular Weight(MW): 545.62

Homoharringtonine, a plant alkaloid with antitumor properties, inhibit protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site

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Biological Activity

Description Homoharringtonine, a plant alkaloid with antitumor properties, inhibit protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (183.27 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 545.62
Formula

C29H39NO9

CAS No. 26833-87-4
Storage powder
in solvent
Synonyms Omacetaxine mepesuccinate

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03910244 Not yet recruiting Drug: Pomalidomide Oral Product|Drug: Placebo oral capsule Telangiectasia Hereditary Hemorrhagic The Cleveland Clinic|RTI International October 2019 Phase 2
NCT03549949 Not yet recruiting -- Hereditary Hemorrhagic Telangiectasia|Dental Diseases University Hospital Essen|Philipps University Marburg Medical Center|University Hospital Aachen|German HHT self-help group June 2018 --
NCT02963129 Unknown status Drug: Mupirocin|Other: Placebo Hereditary Hemorrhagic Telangiectasia|Epistaxis Hospital Italiano de Buenos Aires June 2017 Phase 3
NCT02983253 Recruiting Other: blood sample Hereditary Haemorrhagic Telangiectasia (HHT) University Hospital Essen June 2016 --
NCT02690246 Active not recruiting Other: questionnaire Hereditary Haemorrhagic Telangiectasia (HHT) University Hospital Essen February 2016 --
NCT02484716 Completed Drug: Timolol nasal spray|Drug: Placebo nasal spray Hemorrhagic Hereditary Telangiectasia (HHT) Hospices Civils de Lyon June 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID