Homoharringtonine

For research use only.

Catalog No.S9015 Synonyms: Omacetaxine mepesuccinate

3 publications

Homoharringtonine Chemical Structure

Molecular Weight(MW): 545.62

Homoharringtonine, a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

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Biological Activity

Description Homoharringtonine, a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (183.27 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 545.62
Formula

C29H39NO9

CAS No. 26833-87-4
Storage powder
in solvent
Synonyms Omacetaxine mepesuccinate
Smiles COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04139018 Recruiting Drug: Timolol Gel|Drug: Placebo Gel Hereditary Hemorrhagic Telangiectasia Washington University School of Medicine October 20 2019 Phase 2
NCT03910244 Recruiting Drug: Pomalidomide Oral Product|Drug: Placebo oral capsule Telangiectasia Hereditary Hemorrhagic The Cleveland Clinic|RTI International October 17 2019 Phase 2
NCT04150822 Recruiting Other: Registry and Saliva sample Hereditary Hemorrhagic Telangiectasia|HHT|Brain Arteriovenous Malformation (BAVM) St. Michael''s Hospital Toronto|HHT Foundation International|Dartmouth College November 1 2018 --
NCT03549949 Recruiting -- Hereditary Hemorrhagic Telangiectasia|Dental Diseases University Hospital Essen|Philipps University Marburg Medical Center|University Hospital Aachen|German HHT self-help group June 1 2018 --
NCT02963129 Unknown status Drug: Mupirocin|Other: Placebo Hereditary Hemorrhagic Telangiectasia|Epistaxis Hospital Italiano de Buenos Aires June 2017 Phase 3
NCT02983253 Completed Other: blood sample Hereditary Haemorrhagic Telangiectasia (HHT) University Hospital Essen June 2016 --

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