Home JAK/STAT STAT inhibitor Homoharringtonine (HHT) For research use only.

Homoharringtonine (HHT)

Synonyms: CGX-635, Omacetaxine mepesuccinate, Myelostat, NSC 141633

Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

Homoharringtonine (HHT) Chemical Structure

Homoharringtonine (HHT) Chemical Structure

CAS: 26833-87-4

Selleck's Homoharringtonine (HHT) has been cited by 17 publications

Purity & Quality Control

Batch: Purity: 99.85%
99.85

Homoharringtonine (HHT) Related Products

Signaling Pathway

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Biological Activity

Description Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.
In vitro
In vitro

Homoharringtonine (HHT), a plant alkaloid with antitumor properties, induces p62-mediated autophagy in imatinib-resistant CML K562G cells, thus promoting autophagic degradation of the BCR-ABL protein.[1]
Cell Research Cell lines K562 cells, K562G cells
Concentrations 100, 50, 25, 12.5, 6.2, 3.1, 1.56, 0.78 and 0.39 ng/ml
Incubation Time 48 h
Method

K562, K562G, and siRNA-K562G cells are seeded in 384-well plates at a density of 8,000 cells/well, and then treated with 0.1% DMSO (vehicle control) or HHT at concentrations of 100, 50, 25, 12.5, 6.2, 3.1, 1.56, 0.78 and 0.39 ng/ml for 48 h. According to the manufacturer's instructions, cell proliferation is assayed using an MTS assay, and the absorbance is measured.
In Vivo
In vivo

Homoharringtonine (HHT) in combination with ABT-199, significantly prolongs overall survival of primary diffuse large B-cell lymphoma (DLBCL) xenograft-bearing mice compared with single-agent approaches.[2]
Animal Research Animal Models Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice of xenograft models of DLBCL
Dosages 50 µg/dose
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05954481 Recruiting
Hereditary Hemorrhagic Telangiectasia|Rendu Osler Disease
Hospices Civils de Lyon
 August 3 2023 Not Applicable
NCT03850964 Recruiting
Hereditary Hemorrhagic Telangiectasia|Epistaxis|Anemia|Nosebleed|HHT
Cure HHT
 May 8 2023 Phase 2|Phase 3
NCT04976036 Recruiting
Telangiectasia Hereditary Hemorrhagic
Dr. Romain Lazor|Boehringer Ingelheim|Centre Hospitalier Universitaire Vaudois
 May 5 2022 Phase 2
NCT03910244 Completed
Telangiectasia Hereditary Hemorrhagic
The Cleveland Clinic|RTI International
 October 17 2019 Phase 2
NCT04150822 Recruiting
Hereditary Hemorrhagic Telangiectasia|HHT|Arteriovenous Malformation of Brain
Unity Health Toronto|Cure HHT|Dartmouth College
 November 1 2018 --
NCT03549949 Active not recruiting
Hereditary Hemorrhagic Telangiectasia|Dental Diseases
University Hospital Essen|Philipps University Marburg Medical Center|University Hospital Aachen|German HHT self-help group
 June 1 2018 --

Chemical Information & Solubility

Molecular Weight 545.62 Formula

C29H39NO9
CAS No. 26833-87-4 SDF --
Smiles CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (183.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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