Homoharringtonine (CGX-635)

For research use only.

Catalog No.S9015 Synonyms: Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633

5 publications

Homoharringtonine (CGX-635) Chemical Structure

CAS No. 26833-87-4

Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

Selleck's Homoharringtonine (CGX-635) has been cited by 5 publications

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (183.27 mM)
Ethanol ''''-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 545.62
Formula

C29H39NO9

CAS No. 26833-87-4
Storage powder
in solvent
Synonyms Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633
Smiles CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04976036 Not yet recruiting Drug: Nintedanib|Drug: Placebo Telangiectasia Hereditary Hemorrhagic Dr. Romain Lazor|Boehringer Ingelheim|Centre Hospitalier Universitaire Vaudois September 2021 Phase 2
NCT03910244 Recruiting Drug: Pomalidomide Oral Product|Drug: Placebo oral capsule Telangiectasia Hereditary Hemorrhagic The Cleveland Clinic|RTI International October 17 2019 Phase 2
NCT04150822 Recruiting Other: Registry and Saliva sample Hereditary Hemorrhagic Telangiectasia|HHT|Arteriovenous Malformation of Brain Unity Health Toronto|Cure HHT|Dartmouth College November 1 2018 --
NCT03549949 Recruiting -- Hereditary Hemorrhagic Telangiectasia|Dental Diseases University Hospital Essen|Philipps University Marburg Medical Center|University Hospital Aachen|German HHT self-help group June 1 2018 --
NCT02963129 Unknown status Drug: Mupirocin|Other: Placebo Hereditary Hemorrhagic Telangiectasia|Epistaxis Hospital Italiano de Buenos Aires June 2017 Phase 3
NCT02983253 Completed Other: blood sample Hereditary Haemorrhagic Telangiectasia (HHT) University Hospital Essen June 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

STAT Signaling Pathway Map

Related STAT Products

Tags: buy Homoharringtonine (CGX-635) | Homoharringtonine (CGX-635) supplier | purchase Homoharringtonine (CGX-635) | Homoharringtonine (CGX-635) cost | Homoharringtonine (CGX-635) manufacturer | order Homoharringtonine (CGX-635) | Homoharringtonine (CGX-635) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID