Ochromycinone (STA-21)

For research use only.

Catalog No.S7951

6 publications

Ochromycinone (STA-21) Chemical Structure

CAS No. 111540-00-2

Ochromycinone (STA-21) is a selective STAT3 inhibitor.

Selleck's Ochromycinone (STA-21) has been cited by 6 publications

Purity & Quality Control

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Biological Activity

Description Ochromycinone (STA-21) is a selective STAT3 inhibitor.
Targets
STAT3 [1]
In vitro

In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2]

In vivo In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3]

Protocol

Cell Research:[1]
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  • Cell lines: MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, MCF7, and Caov-3 cells
  • Concentrations: 20 or 30 μM
  • Incubation Time: 48 h
  • Method: Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: IL-1Ra–KO mice
  • Dosages: 0.5 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (68.55 mM)
Ethanol 2 mg/mL (6.52 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 306.31
Formula

C19H14O4

CAS No. 111540-00-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID