Home JAK/STAT STAT inhibitor Ochromycinone (STA-21)

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Ochromycinone (STA-21) STAT inhibitor

Cat.No.S7951

Ochromycinone (STA-21) is a selective STAT3 inhibitor.
Ochromycinone (STA-21) STAT inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 306.31

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Chemical Information, Storage & Stability

Molecular Weight 306.31 Formula

C19H14O4

 Storage (From the date of receipt)
CAS No. 111540-00-2 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

Solubility

In vitro
Batch:

DMSO : 21 mg/mL ( (68.55 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
STAT3 [1]
In vitro
Ochromycinone (STA-21) inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity in cells. It remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, this compound also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2]
In vivo
In IL-1Ra–KO mice, Ochromycinone (STA-21) (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3]
References

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