SH5-07 (SH-5-07)

For research use only.

Catalog No.S7923

SH5-07 (SH-5-07) Chemical Structure

CAS No. 1456632-41-9

SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.

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Biological Activity

Description SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
Targets
STAT3 [1]
In vitro

SH5-07 blocks STAT3 DNA binding activity in vitro and in human glioma, breast, and prostate cancer cells and in v-Src-transformed murine fibroblasts. STAT3-dependent gene transcription is blocked along with Bcl-2, Bcl-xL, Mcl-1, Cyclin D1, c-Myc and Survivin expression[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
30M cells M3ThTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIXSXmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA{OE1iY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JGFt[W2jcjDCcJVmKGG|c3H5MEBKSzVyPUCuNUDPxE1? M2rSNFI1QTByNkGy
127EF cells M2nhWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkTER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNVI4TUZiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JGFt[W2jcjDCcJVmKGG|c3H5MEBKSzVyPUCuNVk2PSEQvF2= MXOyOFkxODZzMh?=
67EF cells NGOwPJFEgXSxdH;4bYNqfHliYYPzZZk> NULUSJJHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPjeHRjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhSWyjbXHyJGJtfWViYYPzZZktKEmFNUC9NE4zOTR3IN88US=> MVyyOFkxODZzMh?=
84EF cells Mn\hR5l1d3SxeHnjbZR6KGG|c3H5 NVS1XnpNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hQDSHRjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhSWyjbXHyJGJtfWViYYPzZZktKEmFNUC9NE4zQTVizszN M3n3PFI1QTByNkGy
73EF cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= M4LLfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFc{TUZiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JGFt[W2jcjDCcJVmKGG|c3H5MEBKSzVyPUCuPFY{PSEQvF2= MWOyOFkxODZzMh?=
25EF cells NXvD[FI{S3m2b4TvfIlkcXS7IHHzd4F6 MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyOWVHKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEOg[IF6eyCkeTDBcIFu[XJiQnz1[UBie3OjeTygTWM2OD1zLkGyNFUh|ryP NFGwPG4zPDlyME[xNi=>
147EF cells M3jJPWZ2dmO2aX;uJIF{e2G7 NWDZbVRGOiC2bzC3NkBpenN? MkPWTY5pcWKrdHnvckBw\iCVVFHUN{BqdiCqdX3hckAyPDeHRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGixc4Doc5J6dGG2ZXSgRoNtNXiOIHzleoVtKGGodHXyJFIhfG9iN{KgbJJ{KGK7IGfld5Rmem5iYnzveJRqdmdiYX7hcJl{cXN? NELBdlMzPDlyME[xNi=>

... Click to View More Cell Line Experimental Data

In vivo In mouse xenograft models of glioma and breast cancer, administration of SH5-07 effectively inhibits tumor growth[1].

Protocol

Cell Research:[1]
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  • Cell lines: Normal mouse fibroblasts (NIH3T3)
  • Concentrations: 0-8 μM
  • Incubation Time: 24-48 h
  • Method: Cells are treated with 0-8 μM agent for 24-48 h. For cell cycle profile analysis, cells are harvested and fixed with 70% ice-cold ethanol and stained with propidium iodide (PI). For apoptosis analysis, cells are collected and stained with FITC-Annexin V using Apoptosis Detection Kit. Both the DNA content of cells and the Annexin V-positive cells are analyzed by FACScan flow cytometer. Cell cycle phase distribution is analyzed using the Cell-Fit program. Data acquisition is gated to exclude cell doublets.
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: female athymic nude mice
  • Dosages: 3, 5 or 6 mg/kg
  • Administration: oral gavage/tail vein injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (159.84 mM)
Ethanol 100 mg/mL (159.84 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 625.61
Formula

C29H28F5N3O5S

CAS No. 1456632-41-9
Storage powder
in solvent
Synonyms N/A
Smiles CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)NO)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID