Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1055 Enzastaurin (LY317615) <1 mg/mL 30 mg/mL <1 mg/mL
S2791 Sotrastaurin <1 mg/mL 87 mg/mL 2 mg/mL
S1421 Staurosporine <1 mg/mL 4 mg/mL <1 mg/mL
S2911 Go 6983 <1 mg/mL 59 mg/mL <1 mg/mL
S7208 Bisindolylmaleimide I (GF109203X) <1 mg/mL 82 mg/mL <1 mg/mL
S1292 Chelerythrine Chloride <1 mg/mL 3 mg/mL <1 mg/mL
S7207 Bisindolylmaleimide IX (Ro 31-8220 Mesylate) <1 mg/mL 100 mg/mL <1 mg/mL
S2554 Daphnetin <1 mg/mL 35 mg/mL <1 mg/mL
S4066 Dequalinium Chloride <1 mg/mL 0.025 mg/mL <1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S3661 2-Methoxy-1,4-naphthoquinone <1 mg/mL 37 mg/mL 3 mg/mL
S2327 Myricitrin <1 mg/mL 93 mg/mL 1 mg/mL
S7663 Ruboxistaurin (LY333531 HCl) <1 mg/mL 50 mg/mL <1 mg/mL
S7119 Go6976 <1 mg/mL 18 mg/mL <1 mg/mL
S8064 Midostaurin (PKC412) <1 mg/mL 100 mg/mL 20 mg/mL
s9101 Ingenol -1 mg/mL 69 mg/mL -1 mg/mL
S3819 Decursinol angelate -1 mg/mL 65 mg/mL -1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Enzastaurin (LY317615)

Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.



Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.



Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.


Go 6983

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.


Bisindolylmaleimide I (GF109203X)

Bisindolylmaleimide I (GF109203X) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.


Chelerythrine Chloride

Chelerythrine is a potent, selective antagonist of PKC with IC50 of 0.66 mM.


Bisindolylmaleimide IX (Ro 31-8220 Mesylate)

Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.



Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.


Dequalinium Chloride

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.



Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.



2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.



Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.


Ruboxistaurin (LY333531 HCl)

LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.



Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.


Midostaurin (PKC412)

Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.



Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.


Decursinol angelate

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.