Phorbol 12-myristate 13-acetate (PMA)

For research use only.

Catalog No.S7791 Synonyms: 12-O-Tetradecanoylphorbol-13-acetate,TPA

15 publications

Phorbol 12-myristate 13-acetate (PMA) Chemical Structure

CAS No. 16561-29-8

Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Size Price Stock Quantity  
10mM (1mL in DMSO) JPY 37568.00 In stock
JPY 18800.00 In stock
JPY 86500.00 In stock
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Selleck's Phorbol 12-myristate 13-acetate (PMA) has been cited by 15 publications

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Biological Activity

Description Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (162.11 mM)
Water Insoluble
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 616.83
Formula

C36H56O8

CAS No. 16561-29-8
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms 12-O-Tetradecanoylphorbol-13-acetate,TPA
Smiles CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03782610 Recruiting -- Patent Ductus Arteriosus|Preterm Infant|Bronchopulmonary Dysplasia|Neurodevelopmental Abnormality Nationwide Children''s Hospital|National Heart Lung and Blood Institute (NHLBI)|Ohio State University|OhioHealth|Mount Carmel Health System April 1 2019 --
NCT03321734 Recruiting Drug: Caffeine|Drug: Placebos Intermittent Hypoxia Children''s National Research Institute|Boston University|Beth Israel Medical Center|University of Massachusetts Worcester|American SIDS Institute|Walter Reed National Military Medical Center|Dartmouth-Hitchcock Medical Center|Children''s Hospital of Philadelphia|Johns Hopkins All Children''s Hospital|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) January 18 2019 Phase 2
NCT00901030 Completed Procedure: Blood drawn Surgery Hamilton Health Sciences Corporation|University Health Network Toronto|London Health Sciences Centre|McMaster University March 2009 --
NCT00721994 Completed Device: Cormet Hip Resurfacing System Osteoarthritis|Avascular Necrosis|Rheumatoid Arthritis Corin May 2008 --
NCT00901160 Terminated Procedure: blood test Blood Clotting McMaster University|University Health Network Toronto|Hamilton Health Sciences Corporation January 2008 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PKC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID