Phorbol 12-myristate 13-acetate (PMA)
For research use only.
Catalog No.S7791 Synonyms: 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate
CAS No. 16561-29-8
Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).
Selleck's Phorbol 12-myristate 13-acetate (PMA) has been cited by 19 publications
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|Description||Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).|
|In vitro||DMSO||100 mg/mL (162.11 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Storage||3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
|Synonyms||12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04986839||Not yet recruiting||Drug: Paracetamol injection|Drug: Ibuprofen injection||Patent Ductus Arteriosus||Manchester University NHS Foundation Trust||October 1 2021||Phase 2|Phase 3|
|NCT04251377||Not yet recruiting||Device: Defensive Antiadhesive Coating DAC® Novagenit SRL||Hip Prosthesis Infection||Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health France||September 2021||Not Applicable|
|NCT04372953||Recruiting||Procedure: Positive End-Expiratory Pressure (PEEP)||Lung Injury|Preterm Birth||Murdoch Childrens Research Institute|University of Pennsylvania|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)||May 4 2021||Not Applicable|
|NCT04531566||Recruiting||Dietary Supplement: Oral Feed|Dietary Supplement: Usual care||Premature Birth||The University of Texas Health Science Center Houston||October 20 2020||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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