Phorbol 12-myristate 13-acetate (PMA)

For research use only.

Catalog No.S7791

10 publications

Phorbol 12-myristate 13-acetate (PMA) Chemical Structure

Molecular Weight(MW): 616.83

Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

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Biological Activity

Description Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (162.11 mM)
Water Insoluble
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 616.83
Formula

C36H56O8

CAS No. 16561-29-8
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04372953 Not yet recruiting Procedure: Positive End-Expiratory Pressure (PEEP) Lung Injury|Preterm Birth Murdoch Childrens Research Institute|Children''s Hospital of Philadelphia|University of Amsterdam December 1 2020 Not Applicable
NCT04251377 Not yet recruiting Device: Defensive Antiadhesive Coating DAC® Novagenit SRL Hip Prosthesis Infection Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health France April 2020 Not Applicable
NCT04075123 Recruiting Other: CPAP Respiratory Insufficiency Syndrome of Newborn Canadian Neonatal Network|MOUNT SINAI HOSPITAL October 1 2019 --
NCT03253263 Recruiting Drug: SHP607 Retinopathy of Prematurity (ROP)|Intraventricular Hemorrhage|Bronchopulmonary Dysplasia|Chronic Lung Disease of Prematurity Shire May 9 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PKC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID