Phorbol 12-myristate 13-acetate (PMA)

For research use only.

Catalog No.S7791 Synonyms: 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate

19 publications

Phorbol 12-myristate 13-acetate (PMA) Chemical Structure

CAS No. 16561-29-8

Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Selleck's Phorbol 12-myristate 13-acetate (PMA) has been cited by 19 publications

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Biological Activity

Description Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (162.11 mM)
Water Insoluble
Ethanol '''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 616.83
Formula

C36H56O8

CAS No. 16561-29-8
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Synonyms 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate
Smiles CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04986839 Not yet recruiting Drug: Paracetamol injection|Drug: Ibuprofen injection Patent Ductus Arteriosus Manchester University NHS Foundation Trust October 1 2021 Phase 2|Phase 3
NCT04251377 Not yet recruiting Device: Defensive Antiadhesive Coating DAC® Novagenit SRL Hip Prosthesis Infection Centre Hospitalier Universitaire de Saint Etienne|Ministry of Health France September 2021 Not Applicable
NCT04372953 Recruiting Procedure: Positive End-Expiratory Pressure (PEEP) Lung Injury|Preterm Birth Murdoch Childrens Research Institute|University of Pennsylvania|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) May 4 2021 Not Applicable
NCT04531566 Recruiting Dietary Supplement: Oral Feed|Dietary Supplement: Usual care Premature Birth The University of Texas Health Science Center Houston October 20 2020 Not Applicable

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PKC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID