H-1152 dihydrochloride

For research use only.

Catalog No.S6214 Synonyms: H-1152 2HCl

H-1152 dihydrochloride Chemical Structure

CAS No. 871543-07-6

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

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Biological Activity

Description H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Targets
ROCK2 [1]
(Cell-free assay)
CaMK2 [1]
(Cell-free assay)
PKG [1]
(Cell-free assay)
Aurora A [1]
(Cell-free assay)
PKA [1]
(Cell-free assay)
0.0120 μM 0.180 μM 0.360 μM 0.745 μM 3.03 μM

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (198.8 mM)
Water 78 mg/mL (198.8 mM)
Ethanol ''78 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.34
Formula

C16H23Cl2N3O2S

CAS No. 871543-07-6
Storage powder
in solvent
Synonyms H-1152 2HCl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID