H-1152 dihydrochloride

Catalog No.S6214 Synonyms: H-1152 2HCl

For research use only.

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

H-1152 dihydrochloride Chemical Structure

CAS No. 871543-07-6

Purity & Quality Control

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Biological Activity

Description H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Targets
ROCK2 [1]
(Cell-free assay)
CaMK2 [1]
(Cell-free assay)
PKG [1]
(Cell-free assay)
Aurora A [1]
(Cell-free assay)
PKA [1]
(Cell-free assay)
Click to View More Targets
0.0120 μM 0.180 μM 0.360 μM 0.745 μM 3.03 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 392.34
Formula

C16H23Cl2N3O2S

CAS No. 871543-07-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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