Go 6983

For research use only.

Catalog No.S2911 Synonyms: GOE 6983, Gö 6983

65 publications

Go 6983 Chemical Structure

CAS No. 133053-19-7

Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.

Selleck's Go 6983 has been cited by 65 publications

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Biological Activity

Description Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.
Targets
PKCγ [1]
(Cell-free assay)
PKCα [1]
(Cell-free assay)
PKCβ [1]
(Cell-free assay)
PKCδ [1]
(Cell-free assay)
PKCζ [1]
(Cell-free assay)
6 nM 7 nM 7 nM 10 nM 60 nM
In vitro

Go 6983 (300 μM) suppresses PKCμ auto-phosphorylation by 20% reduction in NIH3T3 transfected with PKCμ. [1] In hearts reperfused with PMNs and Gö 6983 (100 nM), left ventricular developed pressure (LVDP) and the rate of LVDP recoveres to 89% and 74% of baseline values, respectively, significantly higher than PMNs alone. Gö 6983 (100 nM) significantly reduces PMNs adherence to the endothelium and infiltration into the myocardium compared with Ischemia followed by reperfusion (I/R)+ PMN hearts, and significantly inhibits superoxide release from PMNs by 90%. Gö 6983 attenuates post-I/R cardiac contractile dysfunction in the presence of PMNs, which may be related in part to decreased superoxide production. [2] Gö 6983 significantly inhibits antigen-induced superoxide release from leukocytes of patients previously sensitized to tree pollen. Go 6983 inhibited intracellular Ca(2+) accumulation in human vascular tissue, suggesting a mechanism for its vasodilator properties. [3] Go-6983 (1 μM) combined with Ro-31-8425 (390 nM) slightly inhibits Angiotensin II–induced PLD2 activity in PGSMCs. [4] Go 6983 is isoform-specific PKC inhibitor that target the ATP binding site. Go 6983 inhibits ΔPfPKB activity with an IC50 of 1 μM. In Go 6983 (5 μM)-treated cells, the number of rings in the following cycle is markedly less compared with the control cultures. Go 6983 (5 μM) treatment results in an almost 60% decrease in formation of new rings in P. falciparum cultures. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PC12 MYnGeY5kfGmxbjDhd5NigQ>? NWLhZXhsOC53IN88US=> NGr5dopIVzZ7OEOgZoxw[2unZDD0bIUh\W[oZXP0JI9nKFCPQTDvckB1cGViYXP0bZZifGmxbjDv[kBCc3RiYX7kJG1CWEtiaX7keYNm\CCkeTDJS2YuOQ>? M2HSNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{i4OFQ4Lz5zMEe4PFQ1PzxxYU6=
PC-3 MYnGeY5kfGmxbjDhd5NigQ>? NITNTHcyKM7:TR?= M2PteVIhcA>? MYPHx9Y3QTh|IHHido9o[XSnczD0bIUhXFCDLXnu[JVk\WRiUlfGVkB1emGwc3HjeIl3[XSrb36gdoV{eG:wc3W= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTh7N{KzOkc,OTV6OUeyN|Y9N2F-
HCT116 M2nyS2Z2dmO2aX;uJIF{e2G7 Mn3YNkDPxE1? M1Phb|ghcA>? MkTvZZR1\W63YYTl[EBRVUFvaX7keYNm\CCITFnQJI1TVkFiZYjwdoV{e2mxbh?= M3\i[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEWyOVE3Lz5zNkC1NlUyPjxxYU6=
HT29 Mn7CSpVv[3Srb36gZZN{[Xl? Ml\SNkDPxE1? MWK4JIg> NIPkUmtifHSnboXheIVlKFCPQT3pcoR2[2WmIF\MTXAhdVKQQTDlfJBz\XO|aX;u M2nZXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEWyOVE3Lz5zNkC1NlUyPjxxYU6=
KM20 M3TnV2Z2dmO2aX;uJIF{e2G7 NWPjSHRMOiEQvF2= M3\YXVghcA>? M2TyeYF1fGWwdXH0[YQhWE2DLXnu[JVk\WRiRlzJVEBuWk6DIHX4dJJme3Orb36= NEHxVnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkC1NlUyPid-MU[wOVI2OTZ:L3G+
KM12C MYTGeY5kfGmxbjDhd5NigQ>? MYiyJO69VQ>? NXnLZYRwQCCq Mlj0ZZR1\W63YYTl[EBRVUFvaX7keYNm\CCITFnQJI1TVkFiZYjwdoV{e2mxbh?= M1fFdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEWyOVE3Lz5zNkC1NlUyPjxxYU6=
Caco-2 NYH6UINmTnWwY4Tpc44h[XO|YYm= M2eyR|Ih|ryP M1fiSVghcA>? MmewZ49ueGyndHXsfUBifHSnboXheIVlKFCPQT3pcoR2[2WmIF\MTXAhdVKQQTDlfJBz\XO|aX;u NYTR[YxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wOVI2OTZpPkG2NFUzPTF4PD;hQi=>
A549 NVvhbWxqTnWwY4Tpc44h[XO|YYm= MUmxNEDPxE1? MofpNUBp NVjjeWI{dWG{a3XkcJkhcW6qaXLpeIVlKEGWUN8zV{1{fGmvdXzheIVlKE6DRGDIJI95cWSjc3WgZYN1cX[rdImgZY5lKEh{T{KgZY5lN2:{IGLPV{Bo\W6ncnH0bY9v MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN{NkW4N{c,OjN|Mk[1PFM9N2F-
HeLa NY\TXol3TnWwY4Tpc44h[XO|YYm= NID6OJYzKM7:TR?= M3rIRlQ5KGh? NX;yfmF7e3WycILld5Nm\CC2aHWg[YZn\WO2IH;mJHBOSSCxbjDhdIlkfWyjcnXuJGEucW6mdXPl[EBkgXSxdH;4bYNqfHl? NU\lVm1zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OFc{OzlpPkK0OFQ4OzN7PD;hQi=>
A673 M2LL[JFJXFNiYYPzZZk> NWjlU2FxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFG2O|Mh[2WubIO= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
NB-EBc1 NFjlb5VyUFSVIHHzd4F6 NGLYUXpyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=> MmjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH M4jDTJFJXFNiYYPzZZk> NEfJdWlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1UUCClZXzsdy=> Ml;TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
LAN-5 MX\xTHRUKGG|c3H5 NXXJWFQ5eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
NB1643 MYXxTHRUKGG|c3H5 Mk\vdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR|IHPlcIx{ NWLnTmtRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC NYrIUYNoeUiWUzDhd5NigQ>? NIPUWoFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLV3DJINmdGy| M4nVUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5 MVLxTHRUKGG|c3H5 NHH3WGtyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBNSU5vNTDj[Yxtew>? NVfoUGQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
DAOY NGHTepRyUFSVIHHzd4F6 NUHLT5RkeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
BT-37 NXqzUnVyeUiWUzDhd5NigQ>? M2ruZ5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{ MoezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
TC32 NFP2bY1yUFSVIHHzd4F6 NWfGWZpOeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? M4LzTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41 M3Xkb5FJXFNiYYPzZZk> M2Pj[ZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHJpPDFiY3XscJM> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh30 M{K1UZFJXFNiYYPzZZk> NGnSc|ZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBTcDNyIHPlcIx{ NXjP[2tERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50 M3LkcZFJXFNiYYPzZZk> NWDLOVE1eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| NVjXSZR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-SH M3H6cpFJXFNiYYPzZZk> M1vYRpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vU1igZ4VtdHN? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HEK293 NYXFU21lTnWwY4Tpc44h[XO|YYm= M1LobGlvcGmkaYTpc44hd2ZiQ3H2NU4zKGOjbHPpeY0h[3W{cnXueEBu\WG|dYLl[EB2e2mwZzD3bI9t\SClZXzsJJBifGOqIHPsZY1xKGmwIHj1cYFvKEiHS{K5N{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIILhZoJqfCCOLYT5dIUh[2GuY3n1cUBkcGGwbnXsJJN2[nWwaYTzMEBKSzVyIE2gNlAh|ryPLh?= M3\ZelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI3OTR7MT:nQmNpTU2ETEyvZV4>

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Assay
Methods Test Index PMID
Western blot
PKCη / PKCα / PKCδ / PKCε ; 

PubMed: 22892130     


MCF-7 cells were treated with 1 μM Gö 6983 for 15 h. Total cell lysates were subjected to SDS-PAGE and Western blot analysis was performed using the indicated antibodies. 

22892130
In vivo Go6983 (22.0 μg/mouse, i.v.) strongly inhibits tumor metastasis by 51.2 % in a mouse pulmonary B16BL6 tumor model. [6]

Protocol

Animal Research:

[6]

- Collapse
  • Animal Models: Mice bearing B16BL6 tumors
  • Dosages: 22 μg/mouse
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 59 mg/mL (133.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 442.51
Formula

C26H26N4O3

CAS No. 133053-19-7
Storage powder
in solvent
Synonyms GOE 6983, Gö 6983
Smiles CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID