Topo II Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1228 Idarubicin HCl

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.

Selective Topo II (MCF-7 cells), IC50: 3.3 ng/mL
S3181 Flumequine

Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.

Selective Topo II, IC50: 15 μM
S1225 Etoposide

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

S4119 Pefloxacin Mesylate Dihydrate

Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.

S1393 Pirarubicin

Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.

S7518 Voreloxin (SNS-595)

Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.

S1787 Teniposide

Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).

S2485 Mitoxantrone HCl

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

S1208 Doxorubicin (Adriamycin)

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

S1367 Amonafide

Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.

S1342 Genistein

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

S1940 Levofloxacin

Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

S1509 Norfloxacin

Norfloxacin is a broad-spectrum antibiotic.

S1756 Enoxacin

Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect.

S1340 Gatifloxacin

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

S1463 Ofloxacin

Ofloxacin is a synthetic broad-spectrum antimicrobial agent.

S1464 Marbofloxacin

Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.

S2328 Nalidixic acid

Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.

S2492 Novobiocin Sodium

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.

S4006 Clinafloxacin

Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

S1465 Moxifloxacin HCl

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.

S1327 Ellagic acid

Ellagic acid has antiproliferative and antioxidant property.