Levofloxacin

For research use only.

Catalog No.S1940 Synonyms: Fluoroquinolone

3 publications

Levofloxacin Chemical Structure

Molecular Weight(MW): 361.37

Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
USD 227 In stock
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Biological Activity

Description Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
Targets
Topoisomerase II [1] Topoisomerase IV [1]
In vitro

Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes.[1] Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more active than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant. Levofloxacin inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. [2] Levofloxacin exhibits twofold greater inhibitory and bactericidal activities than ofloxacin against either extracellular or intracellular tubercle bacilli. [3] Levofloxacin has the least inhibitory effect on osteoblastic cell growth, with a 50% inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis.[4] Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells M2LTVWZ2dmO2aX;uJIF{e2G7 NFTq[poyNjVibXnudy=> MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG1CXEVzLX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMT61JI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPUG3Mlkh|ryP MnHwNlMzPDFyMkm=
human 5637 cells Mn\pSpVv[3Srb36gZZN{[Xl? M2HIRVIxOCC2bzCzNFAhfWdxbXy= MkTaNVIhcA>? MkfORY51cWKjY4TldolidCCjY4Tpeol1gSCjZ3HpcpN1KHW{b4DheIhw\2WwaXOgSZNkcGW{aXPobYEh[2:uaTDVWGk5QSCrbn\lZ5Rm\CCrbjDoeY1idiB3NkO3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZoFkfGW{aXHsJIxmfmWuIHH0JFIxOCC2bzCzNFAhfWdxbXygZYZ1\XJiMUKgbJJ{KGK7IIPldolidCCmaXz1eIlwdiCvZYToc4Q> M1;2OlIxOjNzM{mw

... Click to View More Cell Line Experimental Data

In vivo Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. [2]

Protocol

Solubility (25°C)

In vitro DMSO 24 mg/mL (66.41 mM)
Water 11 mg/mL (30.43 mM)
Ethanol 9 mg/mL (24.9 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 361.37
Formula

C18H20FN3O4

CAS No. 100986-85-4
Storage powder
in solvent
Synonyms Fluoroquinolone
Smiles CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04239326 Not yet recruiting Diagnostic Test: targeted Next Generation Sequencing (tNGS) Tuberculosis Multidrug-Resistant Foundation for Innovative New Diagnostics Switzerland April 2020 --
NCT04374188 Recruiting Drug: Ciprofloxacin|Drug: Levofloxacin Nephrolithiasis Diaa Eldin Taha Ramadan Mohamed|Kafrelsheikh University September 1 2019 Not Applicable
NCT04212078 Recruiting Drug: Levofloxacin Ophthalmic|Drug: Cefuroxime Endophthalmitis Postoperative National University of Malaysia|Santen Pharmaceutical Co. Ltd. July 29 2019 Phase 1|Phase 2

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID