Levofloxacin hydrate

For research use only.

Catalog No.S4604 Synonyms: Levofloxacin hemihydrate, Levaquin hydrate, Tavanic hydrate, Quixin hydrate, Iquix hydrate, Cravit hydrate

1 publication

Levofloxacin hydrate Chemical Structure

Molecular Weight(MW): 370.38

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).

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Selleck's Levofloxacin hydrate has been cited by 1 publication

Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
Targets
Topoisomerase II [1]
()

Protocol

Cell Research:

[1]

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  • Cell lines: skin mast cells(from dogs and rats)
  • Concentrations: 30 to 1000 mg/mL
  • Incubation Time: 30 min
  • Method:

    Cell suspension samples (50 mL) (2-5×104 mast cells in each tube for dispersed skin cells or 1 ×105 mast cells in each tube for rat peritoneal cells) in duplicate are equilibrated at 37℃ for 10 min, and then added to polypropylene tubes containing 450 mL test compounds dissolved in Tyrode solution. Histamine release reaction is allowed to proceed for a further 30 min. at the end of which time the reaction is terminated by adding 2 mL ice-cold Tyrode solution and the mixture is centrifuged (450 g for 5 min at 4℃). For determination of total histamine content, mast cells are disrupted in boiling water for 10 min. Histamine concentrations in the resulting supernatant and disrupted cells are determined by the enzyme immunoassay described above.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Adult beagle dogs, male Sprague-Dawley rats
  • Dosages: 0 3, 1, 3 and 10 mg/kg for dogs and 10, 30 and 100 mg/kg for rats
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.79 mM)
Ethanol 10 mg/mL (26.99 mM)
Water 5 mg/mL (13.49 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 370.38
Formula

C18H20FN3O4.1/2H2O

CAS No. 138199-71-0
Storage powder
in solvent
Synonyms Levofloxacin hemihydrate, Levaquin hydrate, Tavanic hydrate, Quixin hydrate, Iquix hydrate, Cravit hydrate
Smiles CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCN(C)CC4)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID