Pixantrone Maleate

Catalog No.S5059 Synonyms: BBR-2778

For research use only.

Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.

Pixantrone Maleate Chemical Structure

CAS No. 144675-97-8

Purity & Quality Control

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Biological Activity

Description Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.
Targets
Topo II [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 557.51
Formula

C17H19N5O2.2C4H4O4

CAS No. 144675-97-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00106600 Completed Drug: Pixantrone IV infusion Acute Myelogenous Leukemia CTI BioPharma March 2005 Phase 1|Phase 2
NCT00060671 Terminated Drug: rituximab|Drug: Pixantrone (BBR 2778) Lymphoma Follicular|Lymphoma Mixed-Cell Follicular|Lymphoma Small Cleaved-Cell Follicular|Lymphoma Low-Grade CTI BioPharma January 2005 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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