Quercetin

Catalog No.S2391 Batch:S239107

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Technical Data

Formula

C15H10O7
Molecular Weight 302.24 CAS No. 117-39-5
Solubility (25°C)* In vitro DMSO 60 mg/mL (198.51 mM)
Ethanol 60 mg/mL (198.51 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)		 PI3Kδ [1]
(Cell-free assay)		 View More
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1]

Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]
In vivo

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3]

LD50: >3000mg/kg (i.g.) [4]

Protocol (from reference)

Cell Assay:

[5]
  • Cell lines

    Sertoli cells

  • Concentrations

    0.1 μM

  • Incubation Time

    24 h

  • Method

    Cells were treated with various concentrations of drug for 24 h.

Customer Product Validation

Data independently produced by Dr. Zhang of Tianjin Medical University, 2011

Selleck's Quercetin has been cited by 38 publications

Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm (2020), 2023, 4(5):e346] PubMed: 37614965
Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm -2020), 2023, 4(5):e346] PubMed: 37614965
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice [ Aging Cell, 2023, e13771.] PubMed: 36704839
Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain [ Cells, 2023, 12(3)380] PubMed: 36766726
Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification [ Medicine (Baltimore), 2023, 102(17):e33360] PubMed: 37115092
A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice [ Nat Commun, 2022, 13(1):7028] PubMed: 36396643
An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile [ J Exp Clin Cancer Res, 2022, 41(1):86] PubMed: 35260172
Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging [ ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138] PubMed: 35014784
Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer [ Biomed Pharmacother, 2022, 154:113628] PubMed: 36058145
Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation [ Int J Mol Sci, 2022, 23-1911163] PubMed: 36232461

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.