Antiviral

Inhibitory Selectivity

Antiviral Products

Catalog No. Information Product Use Citations Product Validations
S1102

U0126-EtOH

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.

S1537

Vadimezan (ASA404)

Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

S2713

Geldanamycin (NSC 122750)

Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.

S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S4879New

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S3356New

Phosphonoacetic acid

Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.

S3380New

Tecovirimat

Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.

S9669New

U18666A

U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.

S2764New

DTNB

DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.

S6867New

Glyceryl monocaprate (Monocaprin)

Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.

S6801New

AKOS B018304

AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.

S1623

Acetylcysteine (N-acetylcysteine)

Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.

S2239

Tubacin

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.

S8750

NGI-1 (ML414)

NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.

S5554

Lanatoside C

Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.

S9303

Saikosaponin B2

Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.

S7775

Emricasan (IDN-6556)

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

S9063

Harringtonine

Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.

S8932

Remdesivir (GS-5734)

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

S6814

GS-441524

GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.

S5952

Baloxavir marboxil

Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.

S3251New

Goitrin

Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.

S2504

Ribavirin (ICN-1229)

Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

S1807

Aciclovir (BW 248U)

Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

S1637

Docosanol

Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)

S2420

Aloperine

Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.

S2486

Moroxydine HCl

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.

S2467

Famciclovir

Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.

S1883

Idoxuridine

Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.

S4184

Penciclovir

Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.

S8071

UNC0638

UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.

S9224

Dehydroandrographolide Succinate

Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.

S5684

Lapachol

Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.

S9278

Saikosaponin C

Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.

S4942

4-Hydroxy-3,5-dimethoxybenzyl alcohol

4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.

S5020

Tilorone dihydrochloride

Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.

S5016

Isoprinosine

Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.

S9078

Epigoitrin

Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.

S6067

2,4-dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.

S2334

Oleanolic Acid

Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.

S9099

Orientin

Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.

S9328

5,6,7-Trimethoxyflavone

5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.

S9120

Scutellarein

Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities

S4518

Chloroxylenol

Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.

S9136

Neochlorogenic acid

Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.

S4408

Procodazole

Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.

Catalog No. Information Product Use Citations Product Validations
S1102

U0126-EtOH

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.

S1537

Vadimezan (ASA404)

Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

S2713

Geldanamycin (NSC 122750)

Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.

S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S4879New

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S3356New

Phosphonoacetic acid

Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.

S3380New

Tecovirimat

Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.

S9669New

U18666A

U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.

S2764New

DTNB

DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.

S6867New

Glyceryl monocaprate (Monocaprin)

Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.

S6801New

AKOS B018304

AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.

S1623

Acetylcysteine (N-acetylcysteine)

Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.

S2239

Tubacin

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.

S8750

NGI-1 (ML414)

NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.

S5554

Lanatoside C

Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.

S9303

Saikosaponin B2

Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.

S7775

Emricasan (IDN-6556)

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

S9063

Harringtonine

Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.

S8932

Remdesivir (GS-5734)

Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.

S6814

GS-441524

GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.

S5952

Baloxavir marboxil

Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.

Catalog No. Information Product Use Citations Product Validations
S3251New

Goitrin

Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.

Catalog No. Information Product Use Citations Product Validations
S2504

Ribavirin (ICN-1229)

Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

S1807

Aciclovir (BW 248U)

Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.

S1637

Docosanol

Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)

S2420

Aloperine

Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.

S2486

Moroxydine HCl

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.

S2467

Famciclovir

Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.

S1883

Idoxuridine

Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.

S4184

Penciclovir

Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.

S8071

UNC0638

UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.

S9224

Dehydroandrographolide Succinate

Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.

S5684

Lapachol

Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.

S9278

Saikosaponin C

Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.

S4942

4-Hydroxy-3,5-dimethoxybenzyl alcohol

4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.

S5020

Tilorone dihydrochloride

Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.

S5016

Isoprinosine

Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.

S9078

Epigoitrin

Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.

S6067

2,4-dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.

S2334

Oleanolic Acid

Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.

S9099

Orientin

Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.

S9328

5,6,7-Trimethoxyflavone

5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.

S9120

Scutellarein

Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities

S4518

Chloroxylenol

Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.

S9136

Neochlorogenic acid

Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.

S4408

Procodazole

Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.