E0010New |
Hypocrellin A
|
Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC. |
|
|
E0110New |
Baloxavir
|
Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
|
|
|
E0150New |
Carrageenan
|
Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
|
|
|
E0153New |
Lithium Chloride
|
Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.
|
|
|
E0365New |
Fucoidan
|
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
|
|
|
S1102 |
U0126-EtOH
|
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
-
Adv Sci (Weinh), 2022, 10.1002/advs.202104055
-
Cell Rep, 2022, 38(11):110522
-
Elife, 2022, 11e76183
|
|
S1401 |
Tenofovir
|
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
-
Cancer Discov, 2022, candisc.1117.2021
-
Antiviral Res, 2022, 203:105348
-
Antiviral Res, 2021, S0166-3542(21)00068-1
|
|
S1537 |
Vadimezan (ASA404)
|
Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. |
-
Cell, 2022, 185(1):169-183.e19
-
Nat Immunol, 2022, 23(2):287-302
-
Nat Cell Biol, 2022, 24(5):766-782
|
|
S1623 |
Acetylcysteine (N-acetylcysteine)
|
Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared. |
-
EMBO Mol Med, 2022, 14(2):e14903
-
J Exp Clin Cancer Res, 2022, 41(1):41
-
Environ Sci Technol, 2022, 10.1021/acs.est.2c00585
|
|
S2239 |
Tubacin
|
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
-
Oncogene, 2022, 10.1038/s41388-022-02236-7
-
Signal Transduct Target Ther, 2021, 6(1):333
-
STAR Protoc, 2021, 2(3):100674
|
|
S2713 |
Geldanamycin (NSC 122750)
|
Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
-
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
-
Anal Chem, 2022, 10.1021/acs.analchem.1c05455
-
Cell Chem Biol, 2021, S2451-9456(21)00221-X
|
|
S2764 |
DTNB
|
DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
|
|
S3356 |
Phosphonoacetic acid
|
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
|
|
S3380 |
Tecovirimat
|
Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection. |
|
|
S4879 |
Tenofovir hydrate
|
Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
-
Cancer Discov, 2022, candisc.1117.2021
-
Cells, 2020, 9(4)E1003
|
|
S5554 |
Lanatoside C
|
Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. |
|
|
S5952New |
Baloxavir marboxil
|
Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug. |
-
bioRxiv, 2020, 2020.08.12.246389
|
|
S6801 |
AKOS B018304
|
AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. |
|
|
S6814 |
GS-441524
|
GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
-
EBioMedicine, 2022, 81:104095
-
Int J Pharm, 2022, 620:121739
-
Toxicol Lett, 2022, 362:50-58
|
|
S6867 |
Glyceryl monocaprate (Monocaprin)
|
Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. |
|
|
S7775 |
Emricasan (IDN-6556)
|
Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
-
Cancer Res, 2022, canres.2076.2021
-
Int Immunopharmacol, 2022, 108:108885
-
Sci Transl Med, 2021, 13(604)eabb1069
|
|
S8750 |
NGI-1 (ML414)
|
NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses. |
-
J Cell Biochem, 2022, 10.1002/jcb.30204
-
Cancer Res, 2018, 78(17):5094-5106
|
|
S8932 |
Remdesivir (GS-5734)
|
Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
-
Nature, 2022, 10.1038/s41586-022-04474-x
-
Cell Rep, 2022, 39(4):110744
-
mBio, 2022, 13(2):e0370521
|
|
S9063 |
Harringtonine
|
Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
-
Research Square, 2021, 10.21203/rs.3.rs-541829/v1
|
|
S9303 |
Saikosaponin B2
|
Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
-
Phytomedicine, 2019, 67:153163
|
|
S9669 |
U18666A
|
U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
|
|
S9926New |
ML-SA1
|
ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
|
|
|
S3251 |
Goitrin
|
Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity. |
|
|
S1637 |
Docosanol
|
Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production) |
|
|
S1807 |
Aciclovir (BW 248U)
|
Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
-
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
-
Microbiol Spectr, 2021, 9(3):e0064621
-
Front Microbiol, 2021, 12:722748
|
|
S1883 |
Idoxuridine
|
Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM. |
|
|
S2334 |
Oleanolic Acid
|
Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties. |
-
J Cell Sci, 2021, 134(8)jcs255273
-
Front Pharmacol, 2021, 12:697483
-
J Asian Nat Prod Res, 2019, 21(6):522-527
|
|
S2420 |
Aloperine
|
Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. |
-
Cancer Cell Int, 2021, 21(1):662
-
Tissue Cell, 2021, 74:101706
-
J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
|
|
S2467 |
Famciclovir
|
Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. |
-
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
|
|
S2486 |
Moroxydine HCl
|
Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S2504 |
Ribavirin (ICN-1229)
|
Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. |
-
Nat Commun, 2022, 13(1):2079
-
Microbiol Spectr, 2022, e0219321
-
Antiviral Res, 2021, 196:105209
|
|
S4184 |
Penciclovir
|
Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity. |
-
Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
-
ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083
-
Antiviral Res, 2021, S0166-3542(21)00068-1
|
|
S4408 |
Procodazole
|
Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections. |
|
|
S4518 |
Chloroxylenol
|
Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus. |
|
|
S4942 |
4-Hydroxy-3,5-dimethoxybenzyl alcohol
|
4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties. |
|
|
S5016 |
Isoprinosine
|
Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities. |
|
|
S5020 |
Tilorone dihydrochloride
|
Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties. |
|
|
S5684 |
Lapachol
|
Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity. |
|
|
S6067 |
2,4-dichlorobenzyl alcohol
|
2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. |
|
|
S8071 |
UNC0638
|
UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. |
-
PLoS Pathog, 2022, 18(5):e1010505
-
Adv Sci (Weinh), 2021, e2100779
-
Sci Adv, 2021, 7(3)eaba8053
|
|
S9078 |
Epigoitrin
|
Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities. |
|
|
S9099 |
Orientin
|
Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. |
|
|
S9120 |
Scutellarein
|
Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities |
|
|
S9136 |
Neochlorogenic acid
|
Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. |
|
|
S9224 |
Dehydroandrographolide Succinate
|
Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects. |
|
|
S9278 |
Saikosaponin C
|
Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities. |
|
|
S9328 |
5,6,7-Trimethoxyflavone
|
5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial. |
|
|
E0010New |
Hypocrellin A
|
Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC. |
|
|
E0110New |
Baloxavir
|
Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
|
|
|
E0150New |
Carrageenan
|
Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
|
|
|
E0153New |
Lithium Chloride
|
Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.
|
|
|
E0365New |
Fucoidan
|
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
|
|
|
S1102 |
U0126-EtOH
|
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
- Adv Sci (Weinh), 2022, 10.1002/advs.202104055
- Cell Rep, 2022, 38(11):110522
- Elife, 2022, 11e76183
|
|
S1401 |
Tenofovir
|
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
- Cancer Discov, 2022, candisc.1117.2021
- Antiviral Res, 2022, 203:105348
- Antiviral Res, 2021, S0166-3542(21)00068-1
|
|
S1537 |
Vadimezan (ASA404)
|
Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. |
- Cell, 2022, 185(1):169-183.e19
- Nat Immunol, 2022, 23(2):287-302
- Nat Cell Biol, 2022, 24(5):766-782
|
|
S1623 |
Acetylcysteine (N-acetylcysteine)
|
Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared. |
- EMBO Mol Med, 2022, 14(2):e14903
- J Exp Clin Cancer Res, 2022, 41(1):41
- Environ Sci Technol, 2022, 10.1021/acs.est.2c00585
|
|
S2239 |
Tubacin
|
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
- Oncogene, 2022, 10.1038/s41388-022-02236-7
- Signal Transduct Target Ther, 2021, 6(1):333
- STAR Protoc, 2021, 2(3):100674
|
|
S2713 |
Geldanamycin (NSC 122750)
|
Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
- ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
- Anal Chem, 2022, 10.1021/acs.analchem.1c05455
- Cell Chem Biol, 2021, S2451-9456(21)00221-X
|
|
S2764 |
DTNB
|
DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
|
|
S3356 |
Phosphonoacetic acid
|
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
|
|
S3380 |
Tecovirimat
|
Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection. |
|
|
S4879 |
Tenofovir hydrate
|
Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
- Cancer Discov, 2022, candisc.1117.2021
- Cells, 2020, 9(4)E1003
|
|
S5554 |
Lanatoside C
|
Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. |
|
|
S5952New |
Baloxavir marboxil
|
Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug. |
- bioRxiv, 2020, 2020.08.12.246389
|
|
S6801 |
AKOS B018304
|
AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. |
|
|
S6814 |
GS-441524
|
GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
- EBioMedicine, 2022, 81:104095
- Int J Pharm, 2022, 620:121739
- Toxicol Lett, 2022, 362:50-58
|
|
S6867 |
Glyceryl monocaprate (Monocaprin)
|
Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. |
|
|
S7775 |
Emricasan (IDN-6556)
|
Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
- Cancer Res, 2022, canres.2076.2021
- Int Immunopharmacol, 2022, 108:108885
- Sci Transl Med, 2021, 13(604)eabb1069
|
|
S8750 |
NGI-1 (ML414)
|
NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses. |
- J Cell Biochem, 2022, 10.1002/jcb.30204
- Cancer Res, 2018, 78(17):5094-5106
|
|
S8932 |
Remdesivir (GS-5734)
|
Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
- Nature, 2022, 10.1038/s41586-022-04474-x
- Cell Rep, 2022, 39(4):110744
- mBio, 2022, 13(2):e0370521
|
|
S9063 |
Harringtonine
|
Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
- Research Square, 2021, 10.21203/rs.3.rs-541829/v1
|
|
S9303 |
Saikosaponin B2
|
Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
- Phytomedicine, 2019, 67:153163
|
|
S9669 |
U18666A
|
U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
|
|