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New Antiviral Products

Catalog No.	Product Name	Information	Product Use Citations
E0010^New	Hypocrellin A	Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0066^New	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
E0110^New	Baloxavir	Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
E0150^New	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
E0153^New	Lithium Chloride	Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.
E0365^New	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
S1102	U0126-EtOH	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	J Am Chem Soc, 2021, 10.1021/jacs.1c05386 Sci Adv, 2021, 7(36):eabi9787 Theranostics, 2021, 11(3):996-1015
S1401	Tenofovir	Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	Antiviral Res, 2021, S0166-3542(21)00068-1 PLoS Pathog, 2020, 16(12):e1009024 Cells, 2020, 17;9(4) pii: E1003
S1537	Vadimezan (ASA404)	Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	Cell, 2022, 185(1):169-183.e19 Yonsei Med J, 2022, 63(1):42-55 J Clin Invest, 2021, e144339
S1623	Acetylcysteine (N-acetylcysteine)	Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.	J Clin Invest, 2021, e152067 EMBO Mol Med, 2021, 13(9):e13193 Elife, 2021, 10e69795
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Signal Transduct Target Ther, 2021, 6(1):333 STAR Protoc, 2021, 2(3):100674 Cancers (Basel), 2020, 12(11)E3172
S2713	Geldanamycin (NSC 122750)	Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	Cell Chem Biol, 2021, S2451-9456(21)00221-X J Virol, 2021, JVI0059421 Int J Pharm, 2021, 610:121272
S2764	DTNB	DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S3380	Tecovirimat	Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.
S4879^New	Tenofovir hydrate	Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.	Cells, 2020, 9(4)E1003
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S5952	Baloxavir marboxil	Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.	bioRxiv, 2020, 2020.08.12.246389
S6801	AKOS B018304	AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
S6814	GS-441524	GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Front Pharmacol, 2020, 11:606097
S6867	Glyceryl monocaprate (Monocaprin)	Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S7775	Emricasan (IDN-6556)	Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Sci Transl Med, 2021, 13(604)eabb1069 Mol Cell, 2021, S1097-2765(21)00458-5 Nat Commun, 2021, 12(1):3526
S8750	NGI-1 (ML414)	NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.	Cancer Res, 2018, 78(17):5094-5106
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Nat Commun, 2021, 12(1):5553 Nat Commun, 2021, 12(1):668 EMBO J, 2021, e107826
S9063	Harringtonine	Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	Research Square, 2021, 10.21203/rs.3.rs-541829/v1
S9303	Saikosaponin B2	Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S9669	U18666A	U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
S9926^New	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
S3251	Goitrin	Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.
S1637	Docosanol	Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)
S1807	Aciclovir (BW 248U)	Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Microbiol Spectr, 2021, 9(3):e0064621 Front Microbiol, 2021, 12:722748 Vet Microbiol, 2021, 265:109313
S1883	Idoxuridine	Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
S2334	Oleanolic Acid	Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.	J Cell Sci, 2021, 134(8)jcs255273 Front Pharmacol, 2021, 12:697483 J Asian Nat Prod Res, 2019, 21(6):522-527
S2420	Aloperine	Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.	Cancer Cell Int, 2021, 21(1):662 Tissue Cell, 2021, 74:101706 J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
S2467	Famciclovir	Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.	Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 10.1007/s13577-021-00579-z Sci Adv, 2020, 6(49)eabd9443
S2486	Moroxydine HCl	Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.	Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 10.1007/s13577-021-00579-z Cancer Cell Int, 2020, 19;20:58
S2504	Ribavirin (ICN-1229)	Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.	Antiviral Res, 2021, 196:105209 Antiviral Res, 2021, S0166-3542(21)00068-1 Int J Mol Sci, 2021, 22(9)4559
S4184	Penciclovir	Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083 Antiviral Res, 2021, S0166-3542(21)00068-1 Sci Adv, 2020, 6(49)eabd9443
S4408	Procodazole	Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.
S4518	Chloroxylenol	Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol	4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.
S5016	Isoprinosine	Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.
S5020	Tilorone dihydrochloride	Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.
S5684	Lapachol	Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S6067	2,4-dichlorobenzyl alcohol	2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.
S8071	UNC0638	UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.	Adv Sci (Weinh), 2021, e2100779 Sci Adv, 2021, 7(3)eaba8053 Oxid Med Cell Longev, 2021, 2021:6650781
S9078	Epigoitrin	Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S9099	Orientin	Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9120	Scutellarein	Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
S9136	Neochlorogenic acid	Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S9224	Dehydroandrographolide Succinate	Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S9278	Saikosaponin C	Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S9328	5,6,7-Trimethoxyflavone	5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
E0010^New	Hypocrellin A	Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0066^New	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
E0110^New	Baloxavir	Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
E0150^New	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
E0153^New	Lithium Chloride	Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.
E0365^New	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
S1102	U0126-EtOH	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	J Am Chem Soc, 2021, 10.1021/jacs.1c05386 Sci Adv, 2021, 7(36):eabi9787 Theranostics, 2021, 11(3):996-1015
S1401	Tenofovir	Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	Antiviral Res, 2021, S0166-3542(21)00068-1 PLoS Pathog, 2020, 16(12):e1009024 Cells, 2020, 17;9(4) pii: E1003
S1537	Vadimezan (ASA404)	Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	Cell, 2022, 185(1):169-183.e19 Yonsei Med J, 2022, 63(1):42-55 J Clin Invest, 2021, e144339
S1623	Acetylcysteine (N-acetylcysteine)	Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.	J Clin Invest, 2021, e152067 EMBO Mol Med, 2021, 13(9):e13193 Elife, 2021, 10e69795
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Signal Transduct Target Ther, 2021, 6(1):333 STAR Protoc, 2021, 2(3):100674 Cancers (Basel), 2020, 12(11)E3172
S2713	Geldanamycin (NSC 122750)	Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	Cell Chem Biol, 2021, S2451-9456(21)00221-X J Virol, 2021, JVI0059421 Int J Pharm, 2021, 610:121272
S2764	DTNB	DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S3380	Tecovirimat	Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.
S4879^New	Tenofovir hydrate	Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.	Cells, 2020, 9(4)E1003
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S5952	Baloxavir marboxil	Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug.	bioRxiv, 2020, 2020.08.12.246389
S6801	AKOS B018304	AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
S6814	GS-441524	GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Front Pharmacol, 2020, 11:606097
S6867	Glyceryl monocaprate (Monocaprin)	Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S7775	Emricasan (IDN-6556)	Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Sci Transl Med, 2021, 13(604)eabb1069 Mol Cell, 2021, S1097-2765(21)00458-5 Nat Commun, 2021, 12(1):3526
S8750	NGI-1 (ML414)	NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.	Cancer Res, 2018, 78(17):5094-5106
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Nat Commun, 2021, 12(1):5553 Nat Commun, 2021, 12(1):668 EMBO J, 2021, e107826
S9063	Harringtonine	Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	Research Square, 2021, 10.21203/rs.3.rs-541829/v1
S9303	Saikosaponin B2	Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S9669	U18666A	U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
S9926^New	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
S3251	Goitrin	Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.
E0010^New	Hypocrellin A	Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0066^New	Theaflavin 3,3'-digallate	Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM.
E0110^New	Baloxavir	Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. BXA inhibits viral RNA transcription via selective inhibition of CEN activity.
E0150^New	Carrageenan	Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
E0153^New	Lithium Chloride	Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats.
E0365^New	Fucoidan	Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
S4879^New	Tenofovir hydrate	Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.	Cells, 2020, 9(4)E1003
S9926^New	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.