| S7775 |
Emricasan (IDN-6556)
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Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
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PLoS Pathogens, February 11, 2026, e1013947
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Journal of Virology, April 27, 2018, e00078-18
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Adv Sci (Weinh), 2026, 13(23):e13317
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| S1537 |
Vadimezan (DMXAA)
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Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. It is also a STING agonist with potential antineoplastic activity, potently inducing IFN-β but relatively low TNF-α expression in vitro. This compound has antiviral activity. Phase 3.
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Cell Chem Biol, 2025, 32(2):280-290.e14
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Commun Biol, 2025, 8(1):1470
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Front Pharmacol, 2025, 16:1528459
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| S1623 |
N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine)
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Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.
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Cancer Research, 2025 Oct 15, 3999-4017
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Signal Transduct Target Ther, 2025, 10(1):341
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J Exp Med, 2025, 222(3)e20241248
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| S8932 |
GS-5734 (Remdesivir)
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Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
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J Microbiol Biotechnol, 2025, 35:e2411063
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Chem Pharm Bull (Tokyo), 2025, 73(4):355-368
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Phytomedicine, 2024, 136:156279
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| S2504 |
Ribavirin (ICN-1229)
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Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.
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Frontiers in Microbiology, November 29, 2019, 2781
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Cell Discovery, November 11, 2025, 89
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bioRxiv, February 23, 2026, Not applicable
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| S1807 |
Acyclovir (Aciclovir)
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Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses, and it induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
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Int J Mol Sci, 2025, 26(15)7185
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Virol Sin, 2025, S1995-820X(25)00102-6
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Nat Commun, 2024, 15(1):9461
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| S2467 |
Famciclovir
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Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.
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iScience, 2024, 27(10):110862
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J Pers Med, 2022, 12(2)258
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Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9
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| S2486 |
Moroxydine HCl
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Moroxydine HCl(ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.
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J Pers Med, 2022, 12(2)258
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Hum Cell, 2022, 10.1007/s13577-022-00671-y
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Biomedicines, 2021, 9(8)996
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| S2420 |
Aloperine
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Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
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Cells, 2025, 14(12)929
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Cancer Cell Int, 2021, 21(1):662
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Tissue Cell, 2021, 74:101706
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| S4184 |
Penciclovir
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Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.
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Cell Insight, June 29, 2022, 1(4):100046
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Proceedings of the National Academy of Sciences, June 2, 2020, 117(22):12368-12374
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BMC Medicine, 2026, nan
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