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Penciclovir Antiviral chemical

Cat.No.S4184

Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.
Penciclovir Antiviral chemical Chemical Structure

Chemical Structure

Molecular Weight: 253.26

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Quality Control

Batch: S418401 DMSO]34 mg/mL]false]Water]1 mg/mL]false]Ethanol]Insoluble]false Purity: 99.94%
99.94

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (134.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 1 mg/mL

Ethanol : Insoluble

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 253.26 Formula

C10H15N5O3

 Storage (From the date of receipt)
CAS No. 39809-25-1 Download SDF Storage of Stock Solutions

Synonyms BRL-39123, VSA 671,NSC-759624 Smiles C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N

Mechanism of Action

In vitro

Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. This compound is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). It is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. This chemical has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. It has activity against several herpes viruses with IC50 of 37.9 μM for HHV-6A and 77.8 μM for HHV-6B. Herpes simplex virus-1 studies indicate that this compound induces apoptosis without causing much genotoxicity.

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00878072 Completed
Herpes Labialis
Novartis Pharmaceuticals|Novartis
 March 25 2009 Phase 2|Phase 3
NCT00098059 Completed
Herpes Simplex
Novartis Pharmaceuticals|Novartis
 February 2005 Phase 3

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