Penciclovir

For research use only.

Catalog No.S4184 Synonyms: BRL-39123, VSA 671

5 publications

Penciclovir Chemical Structure

CAS No. 39809-25-1

Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.

Selleck's Penciclovir has been cited by 5 publications

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Biological Activity

Description Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.
In vitro

Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. [1] Penciclovir has activity against several herpes viruses with IC50 of 37.9 μM for HHV-6A and 77.8 μM for HHV-6B. [2] Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity. [3]

Protocol

Solubility (25°C)

In vitro DMSO 34 mg/mL (134.24 mM)
Water 1 mg/mL (3.94 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 253.26
Formula

C10H15N5O3

CAS No. 39809-25-1
Storage powder
in solvent
Synonyms BRL-39123, VSA 671
Smiles C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00878072 Completed Drug: Famciclovir Herpes Labialis Novartis Pharmaceuticals|Novartis March 25 2009 Phase 2|Phase 3
NCT00098059 Completed Drug: Famciclovir Herpes Simplex Novartis Pharmaceuticals|Novartis February 2005 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID