Penciclovir

Catalog No.S4184 Synonyms: BRL-39123, VSA 671,NSC-759624

For research use only.

Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.

Penciclovir Chemical Structure

CAS No. 39809-25-1

Selleck's Penciclovir has been cited by 6 Publications

Purity & Quality Control

Choose Selective Antiviral Inhibitors

Biological Activity

Description Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.
In vitro

Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. [1] Penciclovir has activity against several herpes viruses with IC50 of 37.9 μM for HHV-6A and 77.8 μM for HHV-6B. [2] Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 253.26
Formula

C10H15N5O3

CAS No. 39809-25-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00878072 Completed Drug: Famciclovir Herpes Labialis Novartis Pharmaceuticals|Novartis March 25 2009 Phase 2|Phase 3
NCT00098059 Completed Drug: Famciclovir Herpes Simplex Novartis Pharmaceuticals|Novartis February 2005 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Penciclovir | Penciclovir ic50 | Penciclovir price | Penciclovir cost | Penciclovir solubility dmso | Penciclovir purchase | Penciclovir manufacturer | Penciclovir research buy | Penciclovir order | Penciclovir mouse | Penciclovir chemical structure | Penciclovir mw | Penciclovir molecular weight | Penciclovir datasheet | Penciclovir supplier | Penciclovir in vitro | Penciclovir cell line | Penciclovir concentration | Penciclovir nmr