Home Microbiology Reverse Transcriptase inhibitor - Antiviral inhibitor Tenofovir hydrate For research use only.

Tenofovir hydrate

Synonyms: GS-1278 hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

Tenofovir hydrate Chemical Structure

Tenofovir hydrate Chemical Structure

CAS: 206184-49-8

Selleck's Tenofovir hydrate has been cited by 2 publications

Purity & Quality Control

Batch: S487901 Water] 10 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

Tenofovir hydrate Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

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Biological Activity

Description Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
In vitro
In vitro

Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV).[1] Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations.[2] Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells.[3] Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT.[4]
In Vivo
In vivo

Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.[5]
Animal Research Animal Models Macaques
Dosages 30 mg/kg
Administration s.c.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05957913 Enrolling by invitation
Multiple Sclerosis
Massachusetts General Hospital|Solving MS
 June 5 2023 Phase 2
NCT05874440 Recruiting
Chronic Hepatitis b Patients
Sohag University
 April 15 2023 --

Chemical Information & Solubility

Molecular Weight 305.23 Formula

C9H16N5O5P
CAS No. 206184-49-8 SDF --
Smiles O.CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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