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LL-37 acetate Antiviral chemical

Name: LL-37 acetate
Brand: Selleck Chemicals
SKU: E2027
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.E2027

LL-37 acetate is a 37-residue, amphipathic, cathelicidin-derived peptide, which exhibits a broad spectrum of antimicrobial activity.

LL-37 acetate Antiviral chemical Chemical Structure

Quality Control

Batch: E202701 Water]90 mg/mL]false]Ethanol]90 mg/mL]false]DMSO]Insoluble]false Purity: 98.62%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

98.62

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Antiviral Inhibitors	Moroxydine HCl Aloperine GS-441524 NGI-1 Harringtonine Oleanolic Acid U-18666A Aloin B Lanatoside C Lapachol

Solubility

In vitro
Batch:

Water : 90 mg/mL

Ethanol : 90 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	4553.31	Formula	C₂₀₇H₃₄₄N₆₀O₅₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	154947-66-7(free base)	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/16716248/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2021-12-09)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02225366	COMPLETED	Melanoma	M.D. Anderson Cancer Center	2015-07-08	PHASE1; PHASE2
NCT04098562	UNKNOWN	Diabetic Foot Ulcer	Fakultas Kedokteran Universitas Indonesia	2019-10	PHASE2
NCT02806414	COMPLETED	Rosacea	University of California, San Diego	2016-07	PHASE1; PHASE2
NCT03270709	TERMINATED	HIV/AIDS; Vitamin D Deficiency; Smoker Lung	Emory University	2018-04-11	PHASE1
NCT01398280	COMPLETED	Rosacea	University of California, San Diego	2011-07	EARLY_PHASE1
NCT00788320	WITHDRAWN	Tuberculosis	Atlanta VA Medical Center	2008-10

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Handling Instructions

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