For research use only.
Catalog No.S9669 Synonyms: U18
CAS No. 3039-71-2
U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
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|Description||U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.|
Viral particles are trapped in the Lamp-1 positive late endosome/lysosome compartment when cells are treated with U18666A. In addition, viral replication is also affected by U18666A treatment. An additive anti-viral effect is found when C75, a fatty acid synthase inhibitor, is used in combination with U81666A, suggesting the role of cholesterol and fatty acid in DENV.
When U18666A is administered to cats experimentally infected with type I FIPV, the development of FIP may be suppressed compared with the control group. However, the number of animals with FIP is too low to establish anti-viral effect of U18666A in cats. Two of the five control cats administered PBS alone develops FIP. Four of the five cats administered U18666A develops no signs of FIP. One cat that temporarily developed fever, has no other clinical symptoms, and no gross lesion is noted on an autopsy after the end of the experiment. The FIPV gene is detected intermittently in feces and saliva regardless of the development of FIP or administration of U18666A.
|In vitro||Water||40 mg/mL (94.32 mM)|
|DMSO||30 mg/mL (70.74 mM)|
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|% DMSO % % Tween 80 % ddH2O|
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