GS-441524

For research use only.

Catalog No.S6814

1 publication

GS-441524 Chemical Structure

CAS No. 1191237-69-0

GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.

Selleck's GS-441524 has been cited by 1 publication

Purity & Quality Control

Choose Selective Antiviral Inhibitors

Biological Activity

Description GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.
Targets
FIPV [1]
(Cell-free assay)
0.78 μM(EC50)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HuH7 M3jVSmZ2dmO2aX;uJIF{e2G7 Ml\XNVAhfU1? M1nNPFI1KGi{cx?= NYjl[IE5S22jeDDpckBpfW2jbjDIeWg4KGOnbHzzJIF{e2W|c3XkJIF{KHS{aYDoc5NxcGG2ZTDjc45k\W62cnH0bY9vKHCncjDtbYxtcW:wIHPlcIx{KGG2IEGwJJVOKGmwY4XiZZRm\CCob4KgNlQhcHK|IH3lZZN2emWmIHHmeIVzKHejc3jveZQh[nliTFOtUXMh[W6jbInzbZMtKEOvYYi9NE4xODByMUe2{txO NIDJZVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OlA6OSd-MkK0OFYxQTF:L3G+
Vero M4m3VGFvfGm4aYLhcEBie3OjeR?= NYXzbGRWOjRiaILz NX3BXZozSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhWGG{YXnu[ox2\W68YTCzJGMhOjR|IHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{BqdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEK0JIhzeyCkeTDNWHMh[XO|YYmsJGVEPTB;MT63Ne69VQ>? NEDLU209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OlA6OSd-MkK0OFYxQTF:L3G+
Vero M2LWUWFvfGm4aYLhcEBie3OjeR?= MYOyOEBpenN? MofuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgV2FTWyClb4LvcoF3cXK3czDUc5JwdnSxLUKgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KGmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgNlQhcHK|IHL5JG1VWyCjc4PhfUwhTUN3ME2yMlI1|ryP MmXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NE[wPVEoRjJ{NES2NFkyRC:jPh?=
HuH7 Mn\nRY51cX[rcnHsJIF{e2G7 NV76Wop6OjRiaILz NUnNZplISW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KENidnnyeZMh\2Wwb4T5dIUhOWJiaX7m[YN1\WRiaX6gbJVu[W5iSIXIO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KGmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgNlQhcHK|IHL5JG1VWyCjc4PhfUwhTUN3ME20MlHPxE1? NEX4WYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OlA6OSd-MkK0OFYxQTF:L3G+
Vero E6 MnnyRY51cX[rcnHsJIF{e2G7 NITNWnIzPCCqcoO= MX\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDE[Y5ofWVidnnyeZMhfHmyZTCyJG5mfyCJdXnu[YEhSyCrbn\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIFW2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhcW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCyOEBpenNiYomgUXRUKGG|c3H5MEBGSzVyPUmuOFbPxE1? MmjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NE[wPVEoRjJ{NES2NFkyRC:jPh?=
HeLa MlPDRY51cX[rcnHsJIF{e2G7 MlP2NlQhcHK| NUHSfG1KSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhYWWubH;3JIZmfmW{II\pdpV{KDF5RDDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNiaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCHQ{WwQVEy|ryP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NkC5NUc,OjJ2NE[wPVE9N2F-
MDCK NXPXWZVqSW62aY\pdoFtKGG|c3H5 Mk\VNlQhcHK| NXGzSGdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKEFidnnyeZMhUDOQMjDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB{NDDodpMh[nliTWTTJIF{e2G7LDDFR|UxRTJ5LkpOwG0> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NkC5NUc,OjJ2NE[wPVE9N2F-
Hep2 M{fQ[WFvfGm4aYLhcEBie3OjeR?= NXjFdXJzPCCmYYnz MnjWRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgVoV{eGm{YYTvdpkhe3mwY4n0bYFtKH[rcoXzJGEzKGmwZnXjeIVlKGmwIHj1cYFvKEincEKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiNDDkZZl{KGK7IFPlcIwuXGm2ZYKgS4xwKGG|c3H5MEBGSzVyPUCuOVPPxE1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF{NEmwO{c,OjhzMkS5NFc9N2F-
HMVEC NIHMOm9CdnSrdnnyZYwh[XO|YYm= MYezJJRwKDRiZHH5dy=> M{XCOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGdHWC2odYPl[EBG[m:uYY\pdpV{KGmwZnXjeIVlKGmwIGTFVnQucW2vb4L0ZYxqgmWmIFjNWmVEKGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDy[ZBtcWOjdHnvckBxemWrbnP1ZoF1\WRid3n0bEBk\WyuczDmc4xtd3enZDDifUB3cXKjbDDpcoZm[3Srb36gcYVie3W{ZXSgZYZ1\XJiMzD0c{A1KGSjeYOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCHQ{WwQVAvPzkQvF2= M3XSVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK0PVA4Lz5{OEGyOFkxPzxxYU6=
HuH7 M4DGWGFvfGm4aYLhcEBie3OjeR?= NH;x[Fc{KGSjeYO= MoLIRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGMhfmm{dYOg[4Vvd3S7cHWgNYIhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCycnXpcoN2[mG2ZXSge4l1cCClZXzsd{Bnd3JiMzDkZZl{KG[xbHzve4VlKGK7II\pdoFtKGmwZnXjeIlwdiCkeTDseYNq\mW{YYPlJIF{e2G7LDDFR|UxRTRwMd88US=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF{NEmwO{c,OjhzMkS5NFc9N2F-
HuH7 Mm\CRY51cX[rcnHsJIF{e2G7 NYXqZWVJOyCmYYnz NWC3W2xtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTWKxbHH2bZJ2eyCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHmeIVzKDNiZHH5d{BjgSCnbnSgdI9qdnRiZHnseZRqd25iYYPzZZktKEWFNUC9NU42|ryP NGCwN4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe5Nlc3Oyd-Mki3PVI4PjN:L3G+

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (199.13 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 291.26
Formula

C12H13N5O4

CAS No. 1191237-69-0
Storage powder
in solvent
Synonyms N/A
Smiles C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04582266 Recruiting Drug: Remdesivir COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) February 12 2021 --
NCT04859244 Completed Drug: GS-441524 COVID-19 Copycat Sciences LLC January 1 2021 Phase 1
NCT04539262 Completed Drug: Remdesivir (RDV)|Drug: Placebo COVID-19 Gilead Sciences September 14 2020 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy GS-441524 | GS-441524 supplier | purchase GS-441524 | GS-441524 cost | GS-441524 manufacturer | order GS-441524 | GS-441524 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID