GS-441524

Catalog No.S6814

For research use only.

GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.

GS-441524 Chemical Structure

CAS No. 1191237-69-0

Selleck's GS-441524 has been cited by 2 Publications

Purity & Quality Control

Choose Selective Antiviral Inhibitors

Biological Activity

Description GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.
Targets
FIPV [1]
(Cell-free assay)
0.78 μM(EC50)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HuH7 NVrVVFFsTnWwY4Tpc44h[XO|YYm= NHu0To0yOCC3TR?= M4fBRlI1KGi{cx?= NIPt[GZEdWG6IHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO|ZXSgZZMhfHKrcHjvd5Bp[XSnIHPvcoNmdnS{YYTpc44heGW{IH3pcIxqd25iY3XscJMh[XRiMUCgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNibXXhd5Vz\WRiYX\0[ZIhf2G|aH;1eEBjgSCOQz3NV{BidmGueYPpd{whS22jeE2wMlAxODBzN{dOwG0> MmnVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NE[wPVEoRjJ{NES2NFkyRC:jPh?=
Vero NH[5[3RCdnSrdnnyZYwh[XO|YYm= MlvONlQhcHK| MnfXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgVIFz[WmwZnz1[Y57[SB|IFOgNlQ{KGmwZnXjeIVlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDJ2IHjyd{BjgSCPVGOgZZN{[XluIFXDOVA:OS55Md88US=> NH\RVXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OlA6OSd-MkK0OFYxQTF:L3G+
Vero MWTBcpRqfmm{YXygZZN{[Xl? Mkm0NlQhcHK| NHvXUYFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUSVKVIHPvdo9v[X[rcoXzJHRwem:wdH:tNkBqdm[nY4Tl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNiaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkAzPCCqcoOgZpkhVVSVIHHzd4F6NCCHQ{WwQVIvOjUQvF2= M1qwfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NES2NFkyLz5{MkS0OlA6OTxxYU6=
HuH7 MoDYRY51cX[rcnHsJIF{e2G7 MVyyOEBpenN? NYi2foo4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KENidnnyeZMh\2Wwb4T5dIUhOWJiaX7m[YN1\WRiaX6gbJVu[W5iSIXIO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KGmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgNlQhcHK|IHL5JG1VWyCjc4PhfUwhTUN3ME20MlHPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2NkC5NUc,OjJ2NE[wPVE9N2F-
Vero E6 NFjqNoRCdnSrdnnyZYwh[XO|YYm= MnT3NlQhcHK| MlTXRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSIVv\3WnII\pdpV{KHS7cHWgNkBP\XdiR4XpcoViKENiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDFOkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KGmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgNlQhcHK|IHL5JG1VWyCjc4PhfUwhTUN3ME25MlQ3|ryP NYjzcW5jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OFYxQTFpPkKyOFQ3ODlzPD;hQi=>
HeLa NHnpNI5CdnSrdnnyZYwh[XO|YYm= M3PjSVI1KGi{cx?= MnLtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgXYVtdG:5IH\leoVzKH[rcoXzJFE4TCCrbn\lZ5Rm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhcW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCyOEBpenNiYomgUXRUKGG|c3H5MEBGSzVyPUGx{txO Mn3QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NE[wPVEoRjJ{NES2NFkyRC:jPh?=
MDCK MojGRY51cX[rcnHsJIF{e2G7 NUXzcmNKOjRiaILz NV\1dXlkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKEFidnnyeZMhUDOQMjDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOgbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB{NDDodpMh[nliTWTTJIF{e2G7LDDFR|UxRTJ5LkpOwG0> NWTEWFB4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OFYxQTFpPkKyOFQ3ODlzPD;hQi=>
Hep2 MlzFRY51cX[rcnHsJIF{e2G7 NFTYUpQ1KGSjeYO= MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDS[ZNxcXKjdH;yfUB{gW6leYTpZYwhfmm{dYOgRVIhcW6oZXP0[YQhcW5iaIXtZY4hUGWyMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB2IHThfZMh[nliQ3XscE1VcXSncjDHcI8h[XO|YYmsJGVEPTB;MD61N:69VQ>? M1LNUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK0PVA4Lz5{OEGyOFkxPzxxYU6=
HMVEC NILiPWtCdnSrdnnyZYwh[XO|YYm= M2ryWVMhfG9iNDDkZZl{ M13qcmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGdHWC2odYPl[EBG[m:uYY\pdpV{KGmwZnXjeIVlKGmwIGTFVnQucW2vb4L0ZYxqgmWmIFjNWmVEKGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDy[ZBtcWOjdHnvckBxemWrbnP1ZoF1\WRid3n0bEBk\WyuczDmc4xtd3enZDDifUB3cXKjbDDpcoZm[3Srb36gcYVie3W{ZXSgZYZ1\XJiMzD0c{A1KGSjeYOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCHQ{WwQVAvPzkQvF2= NHjHXFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGyOFkxPyd-MkixNlQ6ODd:L3G+
HuH7 NWrUemdUSW62aY\pdoFtKGG|c3H5 NYntT2Y2OyCmYYnz NVnydmdmSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KENidnnyeZMh\2Wwb4T5dIUhOWJiaX7m[YN1\WRiaX6gbJVu[W5iSIXIO{Bk\WyuczDwdoVqdmO3YnH0[YQhf2m2aDDj[YxteyCob4KgN{Bl[Xm|IH\vcIxwf2WmIHL5JJZqemGuIHnu[oVkfGmxbjDifUBtfWOrZnXyZZNmKGG|c3H5MEBGSzVyPUSuNe69VQ>? M3nUflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUK0PVA4Lz5{OEGyOFkxPzxxYU6=
HuH7 M17rWGFvfGm4aYLhcEBie3OjeR?= NV;oe5hzOyCmYYnz MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDFZo9t[X[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGh2UDdiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JIVv\CCyb3nueEBlcWy3dHnvckBie3OjeTygSWM2OD1zLkZOwG0> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd7Mke2N{c,Ojh5OUK3OlM9N2F-

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 58 mg/mL
(199.13 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 291.26
Formula

C12H13N5O4

CAS No. 1191237-69-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04582266 Recruiting Drug: Remdesivir COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) February 12 2021 --
NCT04859244 Completed Drug: GS-441524 COVID-19 Copycat Sciences LLC January 1 2021 Phase 1
NCT04539262 Completed Drug: Remdesivir (RDV)|Drug: Placebo COVID-19 Gilead Sciences September 14 2020 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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