Emricasan (IDN-6556)

For research use only.

Catalog No.S7775 Synonyms: PF 03491390, PF-03491390

20 publications

Emricasan (IDN-6556) Chemical Structure

CAS No. 254750-02-2

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

Selleck's Emricasan (IDN-6556) has been cited by 20 publications

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Biological Activity

Description Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
caspase [1]
In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat E6-1 NXjVb3hjTnWwY4Tpc44h[XO|YYm= MkfvTY5pcWKrdHnvckBw\iCDboTpMWZieyCjboTpZo9lgS2rbnT1Z4VlKGOjc4Dhd4UuOyCjY4Tpeol1gSCrbjDoeY1idiCMdYLrZZQhTTZvMTDj[YxteyC3c3nu[{BC[y2GRW\EMWFOSyC|dXLzeJJifGViYomg[ox2d3Knc3PlcoNmKGKjc3XkJIF{e2G7LDDJR|UxKD1iMD6wNFYh|ryPLh?= MlfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NUCyPFcoRjJ7NkWwNlg4RC:jPh?=
JFas MXjGeY5kfGmxbjDhd5NigQ>? NHPUOINKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDKSoF{KGOnbHzzMEBKSzVyIE2gNE4xOjVizszNMi=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJ3ME[zOUc,OTZ{NUC2N|U9N2F-
THP-1 NIHU[oFHfW6ldHnvckBie3OjeR?= M37CdWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IGTIVE0yKGOnbHzzMEBKSzVyIE2gNE4zPyEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJ3ME[zOUc,OTZ{NUC2N|U9N2F-
A673 MW\xTHRUKGG|c3H5 NYX6eHVFeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFG2O|Mh[2WubIO= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Saos-2 M1u0UJFJXFNiYYPzZZk> MnftdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOjb4OtNkBk\Wyucx?= NV2wc2VbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63 (6-TG R) NYewZ25UeUiWUzDhd5NigQ>? NIrodGZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTVegOlMhMDZvVFegVkkh[2WubIO= MnH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB1643 M1L3NpFJXFNiYYPzZZk> NFXOcFByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz M13mUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC M1f4WZFJXFNiYYPzZZk> NVrXN20xeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM> MnjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Growth inhibition assay
Cell viability ; 

PubMed: 27571349     

Dose-response curves displaying the effect of Emricasan treatment cell viabilityi n SNB-19 glioblastoma cells exposed to 3 different ZIKV strains. Values represent mean ± s.d. (n = 3 cultures). Curves represent best fits for calculating IC50, and the insets in each panel report the calculated IC50 value against each strain.

In vivo Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan[1]. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection[2].


Cell Research:[2]
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  • Cell lines: Astrocytes
  • Concentrations: 9 μM
  • Incubation Time: 1 h
  • Method: Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: C57BL/6J mice
  • Dosages: 0.3mg/kg/day
  • Administration: i.g.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (175.59 mM)
Water Insoluble
Ethanol '''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 569.50


CAS No. 254750-02-2
Storage powder
in solvent
Synonyms PF 03491390, PF-03491390
Smiles CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03205345 Unknown status Drug: Emricasan (25 mg)|Drug: Emricasan (5 mg)|Drug: Placebo Decompensated Cirrhosis Conatus Pharmaceuticals Inc. June 28 2017 Phase 2
NCT01653899 Completed Drug: IDN-6556 Diabetes University of Alberta|Conatus Pharmaceuticals Inc. June 2012 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID