Catalog No.S7775 Synonyms: IDN-6556, PF 03491390, PF-03491390
Molecular Weight(MW): 569.50
Emricasan is a potent irreversible pan-caspase inhibitor.
Purity & Quality Control
Choose Selective Caspase Inhibitors
|Description||Emricasan is a potent irreversible pan-caspase inhibitor.|
Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.
|In vivo||Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.|
|In vitro||DMSO||100 mg/mL (175.59 mM)|
|Ethanol||100 mg/mL (175.59 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||IDN-6556, PF 03491390, PF-03491390|
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03205345||Recruiting||Decompensated Cirrhosis||Conatus Pharmaceuticals Inc.||June 28 2017||Phase 2|
|NCT02960204||Active not recruiting||Cirrhosis|Portal Hypertension|Non-alcoholic Steatohepatitis||Conatus Pharmaceuticals Inc.||October 17 2016||Phase 2|
|NCT02686762||Active not recruiting||Non-alcoholic Steatohepatitis|Fibrosis|Liver Diseases||Conatus Pharmaceuticals Inc.||January 26 2016||Phase 2|
|NCT02230670||Completed||Liver Cirrhosis|Hepatic Cirrhosis||Conatus Pharmaceuticals Inc.||August 2014||Phase 2|
|NCT02230683||Completed||Liver Cirrhosis|Hepatic Cirrhosis|Portal Hypertension||Conatus Pharmaceuticals Inc.||August 2014||Phase 2|
|NCT02138253||Completed||Liver Fibrosis|Hepatic Fibrosis|Liver Cirrhosis|Hepatic Cirrhosis||Conatus Pharmaceuticals Inc.||May 2014||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.