Catalog No.S7775 Synonyms: IDN-6556, PF 03491390, PF-03491390
Molecular Weight(MW): 569.50
Emricasan is a potent irreversible pan-caspase inhibitor.
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|Description||Emricasan is a potent irreversible pan-caspase inhibitor.|
Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.
|In vivo||Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.|
|In vitro||DMSO||100 mg/mL (175.59 mM)|
|Ethanol||100 mg/mL (175.59 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||IDN-6556, PF 03491390, PF-03491390|
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03205345||Recruiting||Decompensated Cirrhosis||Conatus Pharmaceuticals Inc.||June 28 2017||Phase 2|
|NCT03479125||Enrolling by invitation||Liver Diseases|Liver Fibrosis|Liver Cirrhosis|NASH Fibrosis|Decompensated Non-Alcoholic Steatohepatitis Cirrhosis|Orthotopic Liver Transplantation||Conatus Pharmaceuticals Inc.||February 27 2018||--|
|NCT02686762||Active not recruiting||Non-alcoholic Steatohepatitis|Fibrosis|Liver Diseases||Conatus Pharmaceuticals Inc.||January 26 2016||Phase 2|
|NCT02230670||Completed||Liver Cirrhosis|Hepatic Cirrhosis||Conatus Pharmaceuticals Inc.||August 2014||Phase 2|
|NCT02230683||Completed||Liver Cirrhosis|Hepatic Cirrhosis|Portal Hypertension||Conatus Pharmaceuticals Inc.||August 2014||Phase 2|
|NCT02138253||Completed||Liver Fibrosis|Hepatic Fibrosis|Liver Cirrhosis|Hepatic Cirrhosis||Conatus Pharmaceuticals Inc.||May 2014||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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