Ribavirin

Catalog No.S2504 Synonyms: NSC-163039, ICN-1229 ,RTCA, Tribavirin

Ribavirin  Chemical Structure

Molecular Weight(MW): 244.20864

Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
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Cited by 4 Publications

3 Customer Reviews

  • (E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.

    Cancer Lett, 2016, 375(1):31-8. . Ribavirin purchased from Selleck.

    Inhibition of viral replication and ensuing myocardial apoptosis ameliorates HDACI-exacerbated viral myocarditis. (A) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and the indicated concentrations of ribavirin for 24 h. Cell extracts were analyzed by Western blotting with the indicated antibodies. (B) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and 200 μg/ml ribavirin for 24 h. CVB3 titers in cell culture supernatants were determined by TCID50 assay (n = 4). (C) Cardiac myocytes were treated with 200 μg/ml ribavirin for 24 h. Cells morphology was examined by light microscope (scale bar, 100 μm). (D to F) CVB3-infected cardiac myocytes (MOI, 5) were treated with 2 μM SAHA in the presence or absence of 800 μg/ml ribavirin for 24 h. (D) Cell morphology was examined by light microscope (scale bar, 100 μm). (E and F) Cells were collected and stained with 7-AAD and FITC-labeled annexin V, followed by flow cytometric analysis (n = 3). (G and H) BALB/c mice were infected with CVB3 on day 0 and then simultaneously treated with SAHA (50 mg/kg) and ribavirin (100 mg/kg) or vehicle PBS daily from day 0 to day 7 p.i. (G) Survival rate was monitored daily until day 7 p.i. (n = 10). (H) Paraffin sections of heart tissues were prepared on day 7 p.i., and cardiac injury was revealed by H&E (scale bar, 50 μm). *, P < 0.05; ***, P < 0.001.

    J Virol, 2015, 89(20):10512-23.. Ribavirin purchased from Selleck.

  • Establishment of Vero-rBoDV-1-Gluc cells to monitor BoDV-1 replication. (A) Dose- and time-dependent inhibitory effects of ribavirin on BoDV-1 replication. Vero-rBoDV-1-Gluc cells were treated with 20 or 40 μM of ribavirin for the indicated periods, and the luciferase activity in the cell supernatant was measured. (B) Quantification of BoDV-1 RNAs in Vero-rBoDV-1-Gluc cells treated with 20 or 40 μM of ribavirin for 72 h. Values are expressed as the mean + S.E. from 3 biological replicates. *, p < 0.05; **, p < 0.01; ****, p < 0.001.

    Antiviral Res, 2017, 143:237-245. Ribavirin purchased from Selleck.

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Biological Activity

Description Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.
In vitro

Ribavirin significantly reduces the efficiency with which progeny subgenomic replicons transfect new cells in the replicon system, although ribavirin has little effect on levels of HCV replication. Ribavirin increases the mutation frequency of HCV, with the highest rates of mutations being found in the NS5A-encoding region. Ribavirin enhances TH1 while inhibiting T 2 cytokine production by stimulated T cells. [1] Ribavirin shows antiviral activity against a variety of RNA viruses and is used in combination with interferon-alpha to treat hepatitis C virus infection. Ribavirin reduces infectious poliovirus production to as little as 0. 00001% in cell culture. [2] Ribavirin's antiviral activity is exerted directly through lethal mutagenesis of the viral genetic material. [3] Ribavirin markedly reduces viral-induced parameters of macrophage activation at physiologic concentrations (up to 500 mg/mL). Ribavirin inhibits the production of IL-4 by Th2 cells, whereas it does not diminish the production of IFN-gamma in Th1 cells. [4] Ribavirin exhibits antiviral activity against a broad range of both DNA and RNA viruses in vitro. Ribavirin is a cytostatic agent and causes a reduction in synthesis of DNA, RNA and proteins in exposed cells. Ribavirin is thought to induce a switch in T-helper cell phenotype from type 2 to type 1. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines MlfxSpVv[3Srb36gZZN{[Xl? MVHF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IFjldpBmeyC|aX3wcIV5KH[rcoXzMVEpUFOYLUGpJE8hfGi7bXnu[UBscW6jc3Wg[IVncWOrZX70JEhVUy1rQkKwNFYhNyCYTWexPFM4KGmwZIXj[YQh[3m2b4DheIhq[2m2eTDifUA2OCViaX6gSVZUVSClZXzsJIxqdmW|LDDFR|UxRTBwMEC1JO69VQ>? MXixNVQ6PTV6Nh?=
MDCK cells MVPGeY5kfGmxbjDhd5NigQ>? NUL3SI1KOyCmYYnz Mmf3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJGIhfmm{dYOgLGIwUEtxNT:3NkkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{B3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczygSWM2OD1yLkC5OEDPxE1? NWXSW5JCOjNzMUexO|M>
mouse L1210 cells NIfrTXpHfW6ldHnvckBie3OjeR?= Ml70NlAuPjBibXnudy=> MkDmTY5pcWKrdHnvckBw\iCLTWDETEBqdiCvb4Xz[UBNOTJzMDDj[YxteyCjc4Pld5Nm\CCjczDmc5Ju[XSrb36gc4YhYzJuOD2zTH1pgXCxeHHueIhqdmViZoLvcUBcOix6LUPIYWlOWCCjZoTldkAzOCC2bzC2NEBucW6|LDDJR|UxRTFizszN M3jnPVIzPTV3MUWy
human CEM cells M1\pe2Z2dmO2aX;uJIF{e2G7 M1XZXlIxNTZyIH3pcpM> MVTJcohq[mm2aX;uJI9nKEmPUFTIJIlvKGi3bXHuJGNGVSClZXzsd{Bie3Onc4Pl[EBieyCob4LtZZRqd25ib3[gX|ItQC1|SG3ofZBwgGGwdHjpcoUh\nKxbTDbNkw5NTOKXVnNVEBi\nSncjCyNEB1dyB4MDDtbY5{NCCLQ{WwQVEh|ryP MlvrNlI2PTVzNUK=
BHK21 cell line NGrt[2xHfW6ldHnvckBie3OjeR?= M3j6TGlvcGmkaYTpc44hd2ZiV3XzeEBPcWynII\pdpV{KF[OUDDy[ZBtcWOxbjDpckBDUEt{MTDj[YxtKGyrbnWsJGVEPTB;MT6xJO69VQ>? Ml3NNVY2Ozl2MEK=
HeLa cell MkL4SpVv[3Srb36gZZN{[Xl? Mn;WSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDy[ZNxcXKjdH;yfUB{gW6jcITpZYwpWlOYKTD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZpkhPTBnIHnuJGhmVGFiY3XscEBtcW6nczygSWM2OD1zLkWg{txO NG\yUo8yOTR7NUW4Oi=>
MDCK cells NVXXd5E5TnWwY4Tpc44h[XO|YYm= M2rxeFM3KGh? MVPBcpRqcW6obIXlcppiKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhUDGQMTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|NjDodpMtKEmFNUC9NU46KM7:TR?= MXmyNlM1OTl2Mx?=
MDBK cells NYfERndSTnWwY4Tpc44h[XO|YYm= MVuyJIRigXN? NVzqR2lOSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhSm:4aX7lJJZqemGuIHTpZZJzcGWjII\pdpV{KDFvTlHEUEBCXEOFIG\SOVM1KGmwZnXjeIVlKGmwIF3ERmsh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdoFtKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFIh\GG7czDieEBOXFNiYYPzZZktKEWFNUC9OE43KM7:TR?= Mn;SNlI6PDR|M{O=
african green monkey Vero cells MYHGeY5kfGmxbjDhd5NigQ>? NWDWPYo{PSCmYYnz M1LLW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHJUXiCDMjDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHmeIVzKDViZHH5d{BjgSCybHHxeYUhemWmdXP0bY9vKGG|c3H5MEBGSzVyPUeg{txO MYSyNFM2QTh7OB?=
HEL cells MXLGeY5kfGmxbjDhd5NigQ>? MkS5Nk0{KGSjeYO= M1LmO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiS1;TJIlv\mWldHXkJIlvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WO2aX;uJIZzd21idnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCyJJRwKDNiZHH5d{BjgSCPVGSgZZN{[XluIFXDOVA:OTBizszN NIDoSmEzODB|NEexNS=>
HEK293 cells MYjGeY5kfGmxbjDhd5NigQ>? NVu4ZWd6OjRiaB?= NUPmXYpuUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czDSUmEu\GWyZX7k[Y51KFKQQTDwc4x6dWW{YYPlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHT1ZYwhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTF3IN88US=> MnS3NlQ{OTN5M{C=
human BE(2)-C cells NEHuRm9HfW6ldHnvckBie3OjeR?= Mn63NVguOjBiaB?= NYGwVFRRSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhX2W|dHXyckBmeXWrbnWg[Y5k\XCqYXzvcZlmdGm2aYOgeolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iQlWoNkkuSyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIGLORUBz\XCuaXPheIlwdiCjZoTldkAyQCC2bzCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVE3KM7:TR?= M4fqdlI1OTVzOUW0
human HuH7-J20 cells M{\a[mZ2dmO2aX;uJIF{e2G7 MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR3YhUk[KMTDpcoZm[3SnZDDpckBpfW2jbjDIeWg4NUp{MDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJIxq\mViY4njcIUh[nlibXXhd5VzcW6pIIPlZ5JmfGWmIHHsb4FtcW6nIIDoc5NxcGG2YYPlJIxmfmWuIIDy[Ylv[3WkYYTl[EB4cXSqIHPlcIx{KG[xcjCxJIhzKG[xbHzve4VlKGK7II\pdoFtKGmwb3P1cIF1cW:wIH\vdkA{KGi{czDt[YF{fXKnZDDheEA4OiCqcoOsJGVEPTB;M{CuOEDPxE1? NF3CSVQzPjR{OEi3NC=>
human MT4 cells NUCxOFFJS3m2b4TvfIlkyqCjc4PhfS=> MYe5OkBp M2HGNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1VPCClZXzsd{Bi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBESzVyPUOxJO69VQ>? NHfLSJoyQTR6MkS4NS=>
human HuH7 cells MmjzR5l1d3SxeHnjxsBie3OjeR?= MUSzJIRigXN? MmCxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjDWlFjKGGodHXyJFMh\GG7czDifUBOXFNiYYPzZZktKEOFNUC9N|Ih|ryP NWHRem43OjJzMECyOVY>
human KB cells M4jIZmZ2dmO2aX;uJIF{e2G7 MXW3NkBp NYjMPYVPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhWmirbn;2bZJ2eyC2eYDlJFE{KGmwZnXjeIVlKGmwIHj1cYFvKEuEIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB5MjDodpMhemWuYYTpeoUhfG9iY3;ueJJwdA>? M4TLOVczOjd|MB?=
human KB cells NHG2bY9HfW6ldHnvckBie3OjeR?= NIKzR20yNTFyMECg{txoN22u MXy3NkBp MYjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDSbIlvd3[rcoXzJJR6eGViMUOgbY5n\WO2ZXSgbY4hcHWvYX6gT2Ih[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGG2IEGgeI8hOTByMDD1[{9udCCjZoTldkA4OiCqcoO= M1yzO|IyOTJ|NB?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (200.64 mM)
Water 49 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.20864
Formula

C8H12N4O5

CAS No. 36791-04-5
Storage powder
in solvent
Synonyms NSC-163039, ICN-1229 ,RTCA, Tribavirin

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03759782 Not yet recruiting Hepatitis B Chronic Ottawa Hospital Research Institute January 10 2019 Phase 3
NCT03759782 Not yet recruiting Hepatitis B Chronic Ottawa Hospital Research Institute January 10 2019 Phase 3
NCT03537196 Enrolling by invitation Hepatitis C|Drug Use|Viral Hepatitis C French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) November 13 2018 Phase 4
NCT03537196 Enrolling by invitation Hepatitis C|Drug Use|Viral Hepatitis C French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) November 13 2018 Phase 4
NCT03585725 Recruiting Follicular Lymphoma|Mantle Cell Lymphoma Weill Medical College of Cornell University September 26 2018 Early Phase 1
NCT03585725 Recruiting Follicular Lymphoma|Mantle Cell Lymphoma Weill Medical College of Cornell University September 26 2018 Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID