IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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Cited by 12 Publications

4 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    Effect of the PAK1-specific inhibitor IPA-3 on the regulatory role of PTPN12-S19E on EGF-induced cell migration. ***P < 0.001 vs. control; ##P < 0.01 vs. PRPN12-WT.

    FASEB J, 2018, 32(1):73-82. IPA-3 purchased from Selleck.

  • Effect of endocytic pathway inhibitors on the uptake of 0.5 μm and 1 μm beads by IgM+ and IgM− cells in peripheral blood leukocytes (PBL). A. Endocytic rate of IgM+ cells and IgM− cells for 0.5 μm beads in the presence of inhibitors (CPZ, dynasore, M-β-CD, nystatin, IPA-3, and NSC23766). B. Endocytic rate of IgM+ cells and IgM− cells for 1 μm beads in the presence of inhibitors. Data are obtained from three independent experiments. *, P < 0.05; **, P < 0.01.

    Fish Shellfish Immunol, 2019, 84:138-147. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell NWnMdIxOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{njRmlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PzZ7NDFOwG0> NHLnTmpUSU6JRWK=
human SW1710 cell M2TSVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3YSWpKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTd6M{Og{txO NFjDd5RUSU6JRWK=
human YT cell NFTBVmZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKGi3bXHuJHlVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|OUCzOkDPxE1? MlmyV2FPT0WU
human BL-70 cell NIjSWmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLvTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFM4QTZizszN NELKeWxUSU6JRWK=
human SIG-M5 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjPTY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlExOjF7IN88US=> NYjMS3V5W0GQR1XS
human MCF7 cell MoS2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlq2TY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xPFA4KM7:TR?= NHjN[2JUSU6JRWK=
human GB-1 cell M4LOSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIHDVlJKdmirYnn0bY9vKG:oIHj1cYFvKEeELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlY{PDl2IN88US=> M325XnNCVkeHUh?=
human KU812 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NE\OV3NKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44PTl3IN88US=> NX\IcmpZW0GQR1XS
human QIMR-WIL cell M3fQZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLWTY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTB6OUGg{txO NIfXWm1USU6JRWK=
human BL-41 cell NH;Me|BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3kNnpKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xQTh2NDFOwG0> NXPhe4dbW0GQR1XS
human CMK cell M4DBcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwMUS1PVkh|ryP NYjMR29uW0GQR1XS
human U-698-M cell M3fyc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVrnUVg6UW6qaXLpeIlwdiCxZjDoeY1idiCXLU[5PE1OKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy5{M{i1OkDPxE1? MlfyV2FPT0WU
human Daoy cell NHHJc3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NITrendKdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> MXHTRW5ITVJ?
human 786-0 cell MoPZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmnjTY5pcWKrdHnvckBw\iCqdX3hckA4QDZvMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|E5ODVizszN M2ixRnNCVkeHUh?=
human REH cell NYruRnNmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\FUllKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|Y3PTVizszN Mn6wV2FPT0WU
human MHH-PREB-1 cell MmS1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjR4Nki3JO69VQ>? NEPWTJZUSU6JRWK=
human KE-37 cell growth M3vtdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3X0RmlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUxOjNzIN88US=> Ml33V2FPT0WU
human CAL-51 cell NUfre|k6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN MV\TRW5ITVJ?
human CA46 cell NYjnPI56T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3nETWlvcGmkaYTpc44hd2ZiaIXtZY4hS0F2NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOlYyQCEQvF2= MlnEV2FPT0WU
human HEL cell M1;ydmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmWwTY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkeyO|Y5KM7:TR?= MkXmV2FPT0WU
human NB6 cell NHzvPIdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlfaTY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkizO|UyKM7:TR?= Ml3VV2FPT0WU
human 8305C cell NUHrOGRFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkT2TY5pcWKrdHnvckBw\iCqdX3hckA5OzB3QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVY4PThizszN NXjN[lYxW0GQR1XS
human EW-13 cell NE\HZ5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNFE1QCEQvF2= NUnVbYVCW0GQR1XS
human NB13 cell M{j2Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fQRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI2PiEQvF2= NUnaR4QxW0GQR1XS
human EB2 cell MlKyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{e1UmlvcGmkaYTpc44hd2ZiaIXtZY4hTUJ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60PVE1OiEQvF2= MlPOV2FPT0WU
human HOS cell NUTzXXBJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYjPVoVSUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfS=> Mn;YV2FPT0WU
human HLE cell NYLPO2ZxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NILjNpNKdmirYnn0bY9vKG:oIHj1cYFvKEiORTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVIyPDlizszN NXv5SYFDW0GQR1XS
human ST486 cell NWjwW3VzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zKc2lvcGmkaYTpc44hd2ZiaIXtZY4hW1R2OE[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlg3PTRizszN NVLYfpNCW0GQR1XS
human NCI-H2009 cell MnnDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFXGfHJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlAxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMESzOVQh|ryP MWDTRW5ITVJ?
human NH-12 cell NYS2SYM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYfJcohq[mm2aX;uJI9nKGi3bXHuJG5JNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT6xNVc3KM7:TR?= NVjv[2FOW0GQR1XS
human BFTC-905 cell NYfvT3N4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWDxOodzUW6qaXLpeIlwdiCxZjDoeY1idiCERmTDMVkxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMUS3Olgh|ryP MXfTRW5ITVJ?
human RKO cell MoSxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVj1cGNSUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI5PDdzIN88US=> NHnFXI9USU6JRWK=
human PF-382 NYrsSWE6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\TVmZEUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjN3MkK2JO69VQ>? Mmm3V2FPT0WU
human SR cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;KOpBSUW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuN|czPTZizszN MlPWV2FPT0WU
human WSU-NHL cell M3OyVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4PFWGlvcGmkaYTpc44hd2ZiaIXtZY4hX1OXLV7IUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTJyNkeg{txO Mmq1V2FPT0WU
human CAL-12T cell NVPwNXNrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVzJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC1zMmSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY1OTRizszN M3TuVHNCVkeHUh?=
human Daudi cell NHfqS4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3jUTmlvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY5PDd5IN88US=> NWjnTHFuW0GQR1XS
human MC-CAR cell M4K3ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1r3WGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvQ1HSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44ODZ2NDFOwG0> NWKyfVVwW0GQR1XS
human RPMI-8402 cell Mlm4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLVTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd4OEe2JO69VQ>? MVnTRW5ITVJ?
human CCRF-CEM cell NYO3fWlxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVvJcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU46PzZ4NzFOwG0> NGjrZ|VUSU6JRWK=
human CHP-126 cell NYO5VWxZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\rTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok44PDJ4ODFOwG0> M{HLZXNCVkeHUh?=
human NB69 cell MonNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MknvTY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj63OlM2OiEQvF2= NYflXJhpW0GQR1XS
human KS-1 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWrJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= M2XwW3NCVkeHUh?=
human J82 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHXTY5pcWKrdHnvckBw\iCqdX3hckBLQDJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkC0PVY2KM7:TR?= M3PpW3NCVkeHUh?=
human SW872 cell M1e0bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfheZhYUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDN3NUig{txO MYPTRW5ITVJ?
human HC-1 cell NXnEVWtsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzJcohq[mm2aX;uJI9nKGi3bXHuJGhENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC2PFA2KM7:TR?= NWjPVodxW0GQR1XS
human DU-145 cell M2XSZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlE1PjRizszN NV7ydnRpW0GQR1XS
human HL-60 cell NXzy[5dWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD64OFYxPSEQvF2= MXTTRW5ITVJ?
human MV-4-11 cell NYDB[VVMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLPeVlKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjF4NEmg{txO NFT2VnJUSU6JRWK=
human SK-N-DZ cell NGG4TolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrtU|dKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjJyNEKzJO69VQ>? MYrTRW5ITVJ?
human HT-1197 cell NHK4fVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEC0WHFKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? MWTTRW5ITVJ?
human NOS-1 cell NW\WZZEzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5QWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuO|E2OiEQvF2= M2HPSXNCVkeHUh?=
human HT-1080 cell MkToS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkS3TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zMEiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPjJ6MzFOwG0> MXrTRW5ITVJ?
human SK-LU-1 cell MofIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDOTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OVT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvQDd|MTFOwG0> NEHmcIRUSU6JRWK=
human SW48 cell NUPjbmFtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPjTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuPFg6PyEQvF2= NEmxPYlUSU6JRWK=
human A2780 cell NIHRcGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkW2TY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID