IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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Cited by 4 Publications

2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M1TwUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVc3QTRizszN NX;QV|JLW0GQR1XS
human SW1710 cell NHfYWlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYXRWoh3UW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF5OEOzJO69VQ>? NEniR5pUSU6JRWK=
human YT cell NGnGVmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3;mUWlvcGmkaYTpc44hd2ZiaIXtZY4hYVRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkO5NFM3KM7:TR?= MYTTRW5ITVJ?
human BL-70 cell M1TKOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnLaTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFM4QTZizszN NFvBfZVUSU6JRWK=
human SIG-M5 cell NYLTd2NDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoP5TY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlExOjF7IN88US=> MYXTRW5ITVJ?
human MCF7 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjNRmtKdmirYnn0bY9vKG:oIHj1cYFvKE2FRkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE5ODdizszN NF;jZoVUSU6JRWK=
human GB-1 cell M{D3cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3yfJlWUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43OzR7NDFOwG0> NIDNW|FUSU6JRWK=
human KU812 cell MoPIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4fUS2lvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTVizszN M4jLOHNCVkeHUh?=
human QIMR-WIL cell M1m2Z2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXfJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODh7MTFOwG0> M1rlRnNCVkeHUh?=
human BL-41 cell MnvtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPVg1PCEQvF2= M2TLc3NCVkeHUh?=
human CMK cell M4G5cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jEbWlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6xOFU6QSEQvF2= NWS5RWtQW0GQR1XS
human U-698-M cell M4TmeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJHUuPjl6LV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI{QDV4IN88US=> M4\qfnNCVkeHUh?=
human Daoy cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHLMUZZKdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> NEG4dFFUSU6JRWK=
human 786-0 cell NXTh[XBIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jNSGlvcGmkaYTpc44hd2ZiaIXtZY4hPzh4LUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMyQDB3IN88US=> MV3TRW5ITVJ?
human REH cell NUHjb|dKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwM{[2OVUh|ryP MXnTRW5ITVJ?
human MHH-PREB-1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWLS[GNWUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitVHJGSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz60OlY5PyEQvF2= Mom2V2FPT0WU
human KE-37 cell growth MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz61NFI{OSEQvF2= NYnEW2FGW0GQR1XS
human CAL-51 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M17IeWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PDVzOTFOwG0> NVTYcVhYW0GQR1XS
human CA46 cell NED1UHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn\qTY5pcWKrdHnvckBw\iCqdX3hckBESTR4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz62OlE5KM7:TR?= M3:5RnNCVkeHUh?=
human HEL cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XsTWlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz63Nlc3QCEQvF2= M3\DdnNCVkeHUh?=
human NB6 cell MonCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOEO3OVEh|ryP MljNV2FPT0WU
human 8305C cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnnGTY5pcWKrdHnvckBw\iCqdX3hckA5OzB3QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVY4PThizszN MXTTRW5ITVJ?
human EW-13 cell NHP6SYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkLSTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlAyPDhizszN NXvwcYFkW0GQR1XS
human NB13 cell MnrMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIPFV5RKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPTZizszN MnLBV2FPT0WU
human EB2 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXjse4Q6UW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ6OTR{IN88US=> MWTTRW5ITVJ?
human HOS cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XtSmlvcGmkaYTpc44hd2ZiaIXtZY4hUE:VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYm= MlPEV2FPT0WU
human HLE cell NYDIbGd6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlTYTY5pcWKrdHnvckBw\iCqdX3hckBJVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkWyNVQ6KM7:TR?= NVu0RnpyW0GQR1XS
human ST486 cell NEXSU2RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTuTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFY2PCEQvF2= M1f1UXNCVkeHUh?=
human NCI-H2009 cell Ml;rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHDWplKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlAxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMESzOVQh|ryP NXLlZ3R5W0GQR1XS
human NH-12 cell MmrQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mne5TY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNVE4PiEQvF2= M4HCfnNCVkeHUh?=
human BFTC-905 cell NWeze3l4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4yPDd4ODFOwG0> MoS1V2FPT0WU
human RKO cell M{HvNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWDCWGdxUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI5PDdzIN88US=> MV7TRW5ITVJ?
human PF-382 M{THNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUDZSWVGUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjN3MkK2JO69VQ>? M3HUenNCVkeHUh?=
human SR cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5|N{K1OkDPxE1? M2nwbnNCVkeHUh?=
human WSU-NHL cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{L3[2lvcGmkaYTpc44hd2ZiaIXtZY4hX1OXLV7IUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTJyNkeg{txO NFfwT4RUSU6JRWK=
human CAL-12T cell NVLXc3dtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jEZ2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUGyWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjRzNDFOwG0> MmnmV2FPT0WU
human Daudi cell MmXsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVjMU2M{UW6qaXLpeIlwdiCxZjDoeY1idiCGYYXkbUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjh2N{eg{txO M2[1[nNCVkeHUh?=
human MC-CAR cell NXrTRoNvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG1ENUODUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|A3PDRizszN NXy0c5FiW0GQR1XS
human RPMI-8402 cell NUHh[|FyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3LSb2lvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55Nki3OkDPxE1? MmfZV2FPT0WU
human CCRF-CEM cell NFLrc5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU46PzZ4NzFOwG0> MnqxV2FPT0WU
human CHP-126 cell Moi3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVftUVJVUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55NEK2PEDPxE1? NG\MNYpUSU6JRWK=
human NB69 cell MnL1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke2N|UzKM7:TR?= NFPlNHZUSU6JRWK=
human KS-1 cell MkDLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{jVVmlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPFg2PDlizszN M3jt[HNCVkeHUh?=
human J82 cell NHL3dpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1zFR2lvcGmkaYTpc44hd2ZiaIXtZY4hUjh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wOFk3PSEQvF2= NH\5T4pUSU6JRWK=
human SW872 cell NXrzUHZiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYX4PZRjUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDN3NUig{txO NWfIWZRjW0GQR1XS
human HC-1 cell NUfn[4VJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rjUGlvcGmkaYTpc44hd2ZiaIXtZY4hUENvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNFY5ODVizszN MkfqV2FPT0WU
human DU-145 cell M1O0UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\EWXFKdmirYnn0bY9vKG:oIHj1cYFvKESXLUG0OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvOjF2NkSg{txO NHflfWhUSU6JRWK=
human HL-60 cell NIXrc2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4mydWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlg1PjB3IN88US=> NFWxWnBUSU6JRWK=
human MV-4-11 cell NX\WZnBuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XmV2lvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOTZ2OTFOwG0> M{nlUXNCVkeHUh?=
human SK-N-DZ cell NXHpWFVlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLDdVhTUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS5{MESyN{DPxE1? NUSxe4FFW0GQR1XS
human HT-1197 cell M375[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYDNOZo6UW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xNVk4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwM{C3N{DPxE1? MlPqV2FPT0WU
human NOS-1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1P1SmlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> NYS5doN3W0GQR1XS
human HT-1080 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7mRWFKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGwPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC54MkizJO69VQ>? NHq1WI9USU6JRWK=
human SK-LU-1 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrueZJJUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOEezNUDPxE1? NXHsSVdUW0GQR1XS
human SW48 cell M4TsfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUTjfnJQUW6qaXLpeIlwdiCxZjDoeY1idiCVV{S4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvQDh7NzFOwG0> NIjp[ZJUSU6JRWK=
human A2780 cell M1PQcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGTzV5hKdmirYnn0bY9vKG:oIHj1cYFvKEF{N{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvOzdzIN88US=> M{Syd3NCVkeHUh?=

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2
CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID