IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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Cited by 8 Publications

2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M3S0OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHvCW2JKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTd4OUSg{txO NUfaR3FzW0GQR1XS
human SW1710 cell M4WxXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPMU2NKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTd6M{Og{txO M3X2SnNCVkeHUh?=
human YT cell NVfYbZVUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYrQbI06UW6qaXLpeIlwdiCxZjDoeY1idiC\VDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|kxOzZizszN MnTzV2FPT0WU
human BL-70 cell M3LjfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTdyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wN|c6PiEQvF2= M{j3ZnNCVkeHUh?=
human SIG-M5 cell MlWwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3i2cWlvcGmkaYTpc44hd2ZiaIXtZY4hW0mJLV21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yODJzOTFOwG0> NEmyXldUSU6JRWK=
human MCF7 cell NYfmXHltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYnkVpNVUW6qaXLpeIlwdiCxZjDoeY1idiCPQ1[3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yQDB5IN88US=> NXXkdFF{W0GQR1XS
human GB-1 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUTJcohq[mm2aX;uJI9nKGi3bXHuJGdDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[zOFk1KM7:TR?= Ml7LV2FPT0WU
human KU812 cell NETz[3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2[xXGlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTVizszN MmPmV2FPT0WU
human QIMR-WIL cell MnPOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFu3[3FKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi57MEi5NUDPxE1? MXnTRW5ITVJ?
human BL-41 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1X1XWlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlA6QDR2IN88US=> MYPTRW5ITVJ?
human CMK cell NV;yRYJMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\EVHJXUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlE1PTl7IN88US=> M3u5V3NCVkeHUh?=
human U-698-M cell MkD1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHUuPjl6LV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI{QDV4IN88US=> NGrLSXJUSU6JRWK=
human Daoy cell NHHJPFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUTDeHJLUW6qaXLpeIlwdiCxZjDoeY1idiCGYX;5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPDZ4MjFOwG0> MoTEV2FPT0WU
human 786-0 cell M{DCNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLZV4tKdmirYnn0bY9vKG:oIHj1cYFvKDd6Nj2wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{OThyNTFOwG0> M1nlU3NCVkeHUh?=
human REH cell NUTudZN{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{DoU2lvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zOlY2PSEQvF2= NFrSO2NUSU6JRWK=
human MHH-PREB-1 cell Ml23S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnK2TY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy52Nk[4O{DPxE1? MkPpV2FPT0WU
human KE-37 cell growth M4H4VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkPZTY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVAzOzFizszN Mn3sV2FPT0WU
human CAL-51 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN NUn4SodpW0GQR1XS
human CA46 cell M1G0bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYC3flhTUW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> MkfBV2FPT0WU
human HEL cell M2nvN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzoTY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkeyO|Y5KM7:TR?= M3jrdHNCVkeHUh?=
human NB6 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOEO3OVEh|ryP M2LwZnNCVkeHUh?=
human 8305C cell NYHKSVlST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFPVTGVKdmirYnn0bY9vKG:oIHj1cYFvKDh|MEXDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPjd3ODFOwG0> M4njNXNCVkeHUh?=
human EW-13 cell M2\zemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1roW2lvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIxOTR6IN88US=> NFXTNGxUSU6JRWK=
human NB13 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYLvbIR7UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjV4IN88US=> Mn\iV2FPT0WU
human EB2 cell Mm\0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGVDOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNEmxOFIh|ryP M{TWSnNCVkeHUh?=
human HOS cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 M374XXNCVkeHUh?=
human HLE cell NWHhfod3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknWTY5pcWKrdHnvckBw\iCqdX3hckBJVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkWyNVQ6KM7:TR?= MW\TRW5ITVJ?
human ST486 cell NWDSSIxIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLsOIJGUW6qaXLpeIlwdiCxZjDoeY1idiCVVES4OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQDZ3NDFOwG0> MUTTRW5ITVJ?
human NCI-H2009 cell NGXPdGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkizTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjB2M{W0JO69VQ>? NYjaR4JXW0GQR1XS
human NH-12 cell MlnXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHv5cHNKdmirYnn0bY9vKG:oIHj1cYFvKE6KLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4yOTd4IN88US=> NEfXdYlUSU6JRWK=
human BFTC-905 cell NUfpPIZGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M17wemlvcGmkaYTpc44hd2ZiaIXtZY4hSk[WQz25NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjF2N{[4JO69VQ>? M4ntNnNCVkeHUh?=
human RKO cell NVLicVZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMki0O|Eh|ryP NVXEfZdUW0GQR1XS
human PF-382 MlPsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\3SWlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4{PTJ{NjFOwG0> Mn3iV2FPT0WU
human SR cell NW\ZbndKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYPsb4t[UW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuN|czPTZizszN M4jlVXNCVkeHUh?=
human WSU-NHL cell NGDDWZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX70Z5d[UW6qaXLpeIlwdiCxZjDoeY1idiCZU2WtUmhNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53MkC2O{DPxE1? NY\ETnJTW0GQR1XS
human CAL-12T cell NGDiVFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPaUW1KdmirYnn0bY9vKG:oIHj1cYFvKEODTD2xNnQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjZ2MUSg{txO NYDjV2xkW0GQR1XS
human Daudi cell NEDyXI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7CTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuOlg1PzdizszN MoPoV2FPT0WU
human MC-CAR cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XGemlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvQ1HSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44ODZ2NDFOwG0> NVGycGpQW0GQR1XS
human RPMI-8402 cell NXHiZmdST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnflTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd4OEe2JO69VQ>? MYTTRW5ITVJ?
human CCRF-CEM cell NXS0SGp{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mlv2TY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTd4Nkeg{txO MWXTRW5ITVJ?
human CHP-126 cell M4HmW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rOdWlvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPzR{Nkig{txO NFn1WllUSU6JRWK=
human NB69 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWXJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke2N|UzKM7:TR?= NWPjeY1zW0GQR1XS
human KS-1 cell NH\RboRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PjN2lvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPFg2PDlizszN Mor5V2FPT0WU
human J82 cell M3jUPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XqVWlvcGmkaYTpc44hd2ZiaIXtZY4hUjh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wOFk3PSEQvF2= MlzoV2FPT0WU
human SW872 cell MmGwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGDNWnpKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45OzV3ODFOwG0> NXPBVId1W0GQR1XS
human HC-1 cell NWG2[JNxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPHTY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wOlgxPSEQvF2= NHPIOIJUSU6JRWK=
human DU-145 cell MoLyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlE1PjRizszN NYnjS49sW0GQR1XS
human HL-60 cell NIPZ[WlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PJ[WlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlg1PjB3IN88US=> MVzTRW5ITVJ?
human MV-4-11 cell NIW4VmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXz5Znl4UW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS5zNkS5JO69VQ>? MUnTRW5ITVJ?
human SK-N-DZ cell M1;nTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXnEUoRCUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS5{MESyN{DPxE1? MlPEV2FPT0WU
human HT-1197 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXPRVJKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? NHjzUHNUSU6JRWK=
human NOS-1 cell NXS5UZNOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVvJcohq[mm2aX;uJI9nKGi3bXHuJG5QWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuO|E2OiEQvF2= M1vnfHNCVkeHUh?=
human HT-1080 cell NWrMNVR2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnCUJpKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGwPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC54MkizJO69VQ>? NVf5fVltW0GQR1XS
human SK-LU-1 cell NVjheW4yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXOOFJQUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOEezNUDPxE1? M3ruZnNCVkeHUh?=
human SW48 cell NXTMd|ZNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGPGcoJKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45QDl5IN88US=> MXzTRW5ITVJ?
human A2780 cell NWXyR2lrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfDT5NKdmirYnn0bY9vKG:oIHj1cYFvKEF{N{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvOzdzIN88US=> MXLTRW5ITVJ?

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID