IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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Cited by 12 Publications

4 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    Effect of the PAK1-specific inhibitor IPA-3 on the regulatory role of PTPN12-S19E on EGF-induced cell migration. ***P < 0.001 vs. control; ##P < 0.01 vs. PRPN12-WT.

    FASEB J, 2018, 32(1):73-82. IPA-3 purchased from Selleck.

  • Effect of endocytic pathway inhibitors on the uptake of 0.5 μm and 1 μm beads by IgM+ and IgM− cells in peripheral blood leukocytes (PBL). A. Endocytic rate of IgM+ cells and IgM− cells for 0.5 μm beads in the presence of inhibitors (CPZ, dynasore, M-β-CD, nystatin, IPA-3, and NSC23766). B. Endocytic rate of IgM+ cells and IgM− cells for 1 μm beads in the presence of inhibitors. Data are obtained from three independent experiments. *, P < 0.05; **, P < 0.01.

    Fish Shellfish Immunol, 2019, 84:138-147. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M3rhemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFThZZNKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTd4OUSg{txO NWXROJBiW0GQR1XS
human SW1710 cell MkLmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{jzOmlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPzh|MzFOwG0> NGDjdodUSU6JRWK=
human YT cell NEHBZ5NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHlVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|OUCzOkDPxE1? NHnaZmpUSU6JRWK=
human BL-70 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXPvW3JiUW6qaXLpeIlwdiCxZjDoeY1idiCETD23NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODN5OU[g{txO NXjve2NvW0GQR1XS
human SIG-M5 cell M1vYVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIXaTXdKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTB{MUmg{txO MY\TRW5ITVJ?
human MCF7 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmX5TY5pcWKrdHnvckBw\iCqdX3hckBOS0Z5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xPFA4KM7:TR?= MoDxV2FPT0WU
human GB-1 cell MnfvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXuyVYlHUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43OzR7NDFOwG0> MkCzV2FPT0WU
human KU812 cell NFnMenBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rWPGlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTVizszN MWLTRW5ITVJ?
human QIMR-WIL cell M132[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUjiTlRLUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUC4PVEh|ryP MlXQV2FPT0WU
human BL-41 cell Mki5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGC1doVKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xQTh2NDFOwG0> MoPBV2FPT0WU
human CMK cell M3[1N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWDB[ZVbUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlE1PTl7IN88US=> MV7TRW5ITVJ?
human U-698-M cell M4LWUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH;JNpFKdmirYnn0bY9vKG:oIHj1cYFvKFVvNkm4MW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ|OEW2JO69VQ>? NGjsZVZUSU6JRWK=
human Daoy cell NX\tXolWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHvwTmVKdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> M{HzfXNCVkeHUh?=
human 786-0 cell M{XScmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVTJcohq[mm2aX;uJI9nKGi3bXHuJFc5Pi1yIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNVgxPSEQvF2= MX3TRW5ITVJ?
human REH cell M{DycGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{XiTWlvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zOlY2PSEQvF2= M4HYbnNCVkeHUh?=
human MHH-PREB-1 cell Mnu1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUX3Z2JFUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitVHJGSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz60OlY5PyEQvF2= MnLGV2FPT0WU
human KE-37 cell growth Mnf0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDSTY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVAzOzFizszN NF[wSHZUSU6JRWK=
human CAL-51 cell M33i[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN NGP4SIpUSU6JRWK=
human CA46 cell NUfISpBKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGNCPDZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lk[2NVgh|ryP M3vTTnNCVkeHUh?=
human HEL cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPRVWlbUW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlczPzZ6IN88US=> NWjmbYNLW0GQR1XS
human NB6 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{PtZWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64N|c2OSEQvF2= MmLwV2FPT0WU
human 8305C cell NVHVTZV5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTCO|dKdmirYnn0bY9vKG:oIHj1cYFvKDh|MEXDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPjd3ODFOwG0> Mn7hV2FPT0WU
human EW-13 cell NHLkeFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlfpTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlAyPDhizszN NUXwfGJFW0GQR1XS
human NB13 cell Mn\rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV[0NWJ1UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjV4IN88US=> MUTTRW5ITVJ?
human EB2 cell NHXhVmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPLdm9oUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ6OTR{IN88US=> MnHzV2FPT0WU
human HOS cell NGDwTFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV2wSodsUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfS=> MormV2FPT0WU
human HLE cell NEjpbHRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnfjTY5pcWKrdHnvckBw\iCqdX3hckBJVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkWyNVQ6KM7:TR?= MYPTRW5ITVJ?
human ST486 cell NVTCfnZ4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHD[4dqUW6qaXLpeIlwdiCxZjDoeY1idiCVVES4OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQDZ3NDFOwG0> MVLTRW5ITVJ?
human NCI-H2009 cell MkDzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnjTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjB2M{W0JO69VQ>? M2f5OnNCVkeHUh?=
human NH-12 cell MnrhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Moe2TY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNVE4PiEQvF2= NEXZWFdUSU6JRWK=
human BFTC-905 cell NFHvfmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1vSUGlvcGmkaYTpc44hd2ZiaIXtZY4hSk[WQz25NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjF2N{[4JO69VQ>? MnnPV2FPT0WU
human RKO cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYTtRphwUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI5PDdzIN88US=> MmPsV2FPT0WU
human PF-382 MljsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mle4TY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM2OjJ4IN88US=> NX\U[5g2W0GQR1XS
human SR cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkK3TY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwM{eyOVYh|ryP NHqwWJlUSU6JRWK=
human WSU-NHL cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NELVPZdKdmirYnn0bY9vKG:oIHj1cYFvKFeVVT3OTGwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjV{ME[3JO69VQ>? NWDxbHI{W0GQR1XS
human CAL-12T cell NHz2c4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIrzdJhKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2xNnQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjZ2MUSg{txO MXXTRW5ITVJ?
human Daudi cell Mlu2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT62PFQ4PyEQvF2= MXXTRW5ITVJ?
human MC-CAR cell NIDMO5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfSTJRKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVPBVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzB4NESg{txO NVK0Xo5PW0GQR1XS
human RPMI-8402 cell NFLXU3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoOwTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd4OEe2JO69VQ>? NYm2clVrW0GQR1XS
human CCRF-CEM cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1LkNWlvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njl5Nk[3JO69VQ>? MX7TRW5ITVJ?
human CHP-126 cell NY[ybXJpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7lUIhrUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55NEK2PEDPxE1? NYPkdVdoW0GQR1XS
human NB69 cell NX7lc2tJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVj0OoV6UW6qaXLpeIlwdiCxZjDoeY1idiCQQk[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok44PjN3MjFOwG0> MWfTRW5ITVJ?
human KS-1 cell M{j5ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nqWWlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPFg2PDlizszN NUTucoc3W0GQR1XS
human J82 cell M4jWVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4DuTmlvcGmkaYTpc44hd2ZiaIXtZY4hUjh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wOFk3PSEQvF2= MUTTRW5ITVJ?
human SW872 cell NHm0dm1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LzWGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlg{PTV6IN88US=> M1qzOHNCVkeHUh?=
human HC-1 cell NH\KdnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn[0TY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wOlgxPSEQvF2= MkC4V2FPT0WU
human DU-145 cell NUTC[pd7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M33IcGlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvMUS1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zOTR4NDFOwG0> MVjTRW5ITVJ?
human HL-60 cell Ml3JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4D0V2lvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlg1PjB3IN88US=> NHnn[nZUSU6JRWK=
human MV-4-11 cell M1P3Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWfJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlE3PDlizszN MYTTRW5ITVJ?
human SK-N-DZ cell Mn75S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInkUGVKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjJyNEKzJO69VQ>? NVT1RldFW0GQR1XS
human HT-1197 cell NV7QWodZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzQSmtKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? NHe1e21USU6JRWK=
human NOS-1 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DnfmlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> NYTMXG5SW0GQR1XS
human HT-1080 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDnTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zMEiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPjJ6MzFOwG0> Mme2V2FPT0WU
human SK-LU-1 cell NFvNblZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJHNMNUyXLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPE45PzNzIN88US=> MXzTRW5ITVJ?
human SW48 cell MlnsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4WwUmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d2ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlg5QTdizszN NGD6RVdUSU6JRWK=
human A2780 cell M1nVUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmPsTY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= MYTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID