Wnt/beta-catenin

Choose Selective Wnt/beta-catenin Inhibitors

Wnt/beta-catenin Signaling Pathway Map

Wnt/beta-catenin Signaling Pathways

Wnt/beta-catenin Products

  • All (48)
  • Wnt/beta-catenin Inhibitors (28)
  • Wnt/beta-catenin Antibodies (2)
  • Wnt/beta-catenin Activators (9)
  • Wnt/beta-catenin Antagonists (2)
  • Wnt/beta-catenin Agonists (3)
  • Wnt/beta-catenin Modulators (4)
  • New Wnt/beta-catenin Products
Catalog No. Product Name Information Product Use Citations Product Validations
E0033New IWP-4

IWP-4 is a potent Wnt/β-catenin signaling pathway inhibitor with an IC50 of 25 nM.

E0072New Indirubin-3′-oxime Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
S1180 XAV-939 XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
Int J Biol Sci, 2022, 18(5):2032-2046
Front Pharmacol, 2022, 13:798436
Stem Cell Rev Rep, 2022, 10.1007/s12015-022-10339-7
S2662 Foscenvivint (ICG-001) Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
Cell Death Dis, 2022, 13(3):265
PLoS Pathog, 2022, 18(3):e1010354
Int J Mol Sci, 2022, 23(5)2834
S2788 Capmatinib (INCB28060) Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
PLoS Pathog, 2022, 18(1):e1010247
Cancers (Basel), 2022, 14(6)1378
Oncogene, 2022, 10.1038/s41388-021-02136-2
S3238 Resibufogenin Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
S3842 Isoquercitrin Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.
Cancers (Basel), 2021, 13(16)4200
Signal Transduct Target Ther, 2019, 4:63
S5554 Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S6699New Gigantol Gigantol is a bibenzyl component isolated from several medicinal orchids, which can inhibit Wnt/β-catenin pathway and has anti-tumor activity.
S6745 JW55 JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
Chin J Integr Med, 2021, 10.1007/s11655-021-3282-0
Oncotarget, 2021, 12(7):674-685
S6898 RCM-1 RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.
S6901 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
Clin Transl Med, 2022, 12(2):e684
Front Cell Dev Biol, 2021, 9:648201
S7085 IWP-2 IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
Adv Sci (Weinh), 2022, e2104299
Cell Rep, 2022, 38(10):110468
Basic Res Cardiol, 2022, 117(1):9
S7086 IWR-1-endo IWR-1-endo (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Cell Rep, 2022, 38(9):110457
Aging (Albany NY), 2022, 14(2):800-810
Sci Rep, 2022, 12(1):7
S7096 KY02111 KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
Sci Rep, 2022, 12(1):7
Stem Cell Res, 2022, 60:102686
Stem Cells, 2021, 10.1002/stem.3328
S7484 FH535 FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
Sci Rep, 2022, 12(1):7
J Exp Clin Cancer Res, 2021, 40(1):230
Cell Oncol (Dordr), 2021, 10.1007/s13402-021-00590-4
S7490 WIKI4 WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
Sci Rep, 2022, 12(1):7
Carcinogenesis, 2020, 41(7):993-1004
Nat Commun, 2019, 10(1):4363
S7981 CCT251545 CCT251545 is a potent, orally bioavailable inhibitor of WNT signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Front Cell Dev Biol, 2020, 8:408
S8129 Salinomycin (from Streptomyces albus) Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.
Front Pharmacol, 2022, 13:795934
Viruses, 2021, 13(4)580
Front Chem, 2020, 8:649
S8248 IQ-1 IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
S8327 KYA1797K KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).
Sci Rep, 2022, 12(1):7
mBio, 2021, 12(6):e0279221
Front Endocrinol (Lausanne), 2021, 12:676403
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
Sci Rep, 2022, 12(1):7
Neoplasia, 2019, 21(4):389-400
J Biol Chem, 2018, 293(52):20014-20028
S8429 PNU-74654 PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.
PLoS Pathog, 2022, 18(3):e1010354
Front Cell Dev Biol, 2022, 10:800181
Int J Mol Sci, 2022, 23(5)2834
S8474 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.
Sci Rep, 2022, 12(1):7
Acta Biochim Biophys Sin (Shanghai), 2021, gmab103
Cancers (Basel), 2020, 12(10)E3003
S8704 iCRT14 iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay.
PLoS Pathog, 2022, 18(3):e1010354
Theranostics, 2021, 11(6):2966-2986
S8761 Adavivint (SM04690) Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
PLoS Pathog, 2022, 18(3):e1010354
Mol Carcinog, 2021, 10.1002/mc.23308
Sci China Life Sci, 2021, 10.1007/s11427-021-1933-7
S8968 PRI-724 PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
EMBO Mol Med, 2022, e14990
Sci Rep, 2022, 12(1):7
mBio, 2021, 12(6):e0279221
S9416 Triptonide Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.
A5038 Beta Catenin Rabbit Recombinant mAb

Beta Catenin Antibody detects endogenous levels of total beta Catenin.

J Hematol Oncol, 2021, 14(1):178
Aging (Albany NY), 2021, 13(6):8989-9010
Cell Prolif, 2020, 53(6):e12825
A5072 Catenin alpha 1 Rabbit Recombinant mAb Catenin alpha 1 Rabbit Recombinant mAb detects endogenous levels of Catenin alpha 1.
S1263 Laduviglusib (CHIR-99021) Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
Cell Stem Cell, 2022, S1934-5909(22)00010-8
Adv Sci (Weinh), 2022, e2104299
Nat Commun, 2022, 13(1):1204
S2924 Laduviglusib (CHIR-99021) HCl Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.
Mol Cell, 2022, 82(6):1169-1185.e7
Adv Sci (Weinh), 2022, e2104299
Autophagy, 2022, 10.1080/15548627.2022.2055285
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
S3630 Methyl Vanillate Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
Sci Rep, 2022, 12(1):7
S6085 KY19382 (A3051) KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.
S7421 CGP 57380 CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.
J Cancer, 2020, 11(4):990-996
Bioorg Med Chem, 2018, 26(16):4602-4614
Cancer Lett, 2016, 10.1016/j.canlet.2016.02.052
S7914 Isoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.
Front Cell Dev Biol, 2021, 9:728352
S7954 CP21R7 (CP21) CP21R7 (CP21) is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
Sci Rep, 2022, 12(1):7
ACS Nano, 2021, 10.1021/acsnano.1c06452
Sci Adv, 2020, 6(30):eaba7606
S8178 Wnt agonist 1 Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
Sci Rep, 2022, 12(1):7
Oncol Rep, 2022, 47(3)50
Cell, 2021, 184(1):243-256.e18
S0733 Tegatrabetan (BC-2059) Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
S8647 iCRT3 iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.
EMBO Mol Med, 2022, e14990
Gastroenterology, 2021, S0016-5085(21)03489-2
Cancer Manag Res, 2021, 13:1901-1907
S5815 WAY-316606 WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.
J Bone Miner Res, 2021, 10.1002/jbmr.4435
S8320 SKL2001 SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.
Int J Biol Sci, 2022, 18(5):2032-2046
Sci Rep, 2022, 12(1):7
Cell Mol Life Sci, 2021, 10.1007/s00018-021-03972-x
S9828 WAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1).
S0458 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
S2431 TMTD (Tetramethylthiuram disulfide) TMTD (Tetramethylthiuram disulfide) can reduce the growth performance of chickens through decreasing liver index, whereas increasing kidney, cardiac, and spleen index, and induces tibial dyschondrolplasia (TD) by changing the expressions of VEGF, HIF-1α and WNT4. TMTD (Tetramethylthiuram disulfide) is widely used in rubber processing as an ultra accelerator for low-temperature cures and in agriculture as an important pesticide.
S5992 Heparan Sulfate Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
S6961 Foxy-5 Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.
E0033New IWP-4

IWP-4 is a potent Wnt/β-catenin signaling pathway inhibitor with an IC50 of 25 nM.

E0072New Indirubin-3′-oxime Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
S1180 XAV-939 XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
Int J Biol Sci, 2022, 18(5):2032-2046
Front Pharmacol, 2022, 13:798436
Stem Cell Rev Rep, 2022, 10.1007/s12015-022-10339-7
S2662 Foscenvivint (ICG-001) Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
Cell Death Dis, 2022, 13(3):265
PLoS Pathog, 2022, 18(3):e1010354
Int J Mol Sci, 2022, 23(5)2834
S2788 Capmatinib (INCB28060) Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
PLoS Pathog, 2022, 18(1):e1010247
Cancers (Basel), 2022, 14(6)1378
Oncogene, 2022, 10.1038/s41388-021-02136-2
S3238 Resibufogenin Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
S3842 Isoquercitrin Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.
Cancers (Basel), 2021, 13(16)4200
Signal Transduct Target Ther, 2019, 4:63
S5554 Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S6699New Gigantol Gigantol is a bibenzyl component isolated from several medicinal orchids, which can inhibit Wnt/β-catenin pathway and has anti-tumor activity.
S6745 JW55 JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
Chin J Integr Med, 2021, 10.1007/s11655-021-3282-0
Oncotarget, 2021, 12(7):674-685
S6898 RCM-1 RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.
S6901 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
Clin Transl Med, 2022, 12(2):e684
Front Cell Dev Biol, 2021, 9:648201
S7085 IWP-2 IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
Adv Sci (Weinh), 2022, e2104299
Cell Rep, 2022, 38(10):110468
Basic Res Cardiol, 2022, 117(1):9
S7086 IWR-1-endo IWR-1-endo (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Cell Rep, 2022, 38(9):110457
Aging (Albany NY), 2022, 14(2):800-810
Sci Rep, 2022, 12(1):7
S7096 KY02111 KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
Sci Rep, 2022, 12(1):7
Stem Cell Res, 2022, 60:102686
Stem Cells, 2021, 10.1002/stem.3328
S7484 FH535 FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
Sci Rep, 2022, 12(1):7
J Exp Clin Cancer Res, 2021, 40(1):230
Cell Oncol (Dordr), 2021, 10.1007/s13402-021-00590-4
S7490 WIKI4 WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
Sci Rep, 2022, 12(1):7
Carcinogenesis, 2020, 41(7):993-1004
Nat Commun, 2019, 10(1):4363
S7981 CCT251545 CCT251545 is a potent, orally bioavailable inhibitor of WNT signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Front Cell Dev Biol, 2020, 8:408
S8129 Salinomycin (from Streptomyces albus) Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.
Front Pharmacol, 2022, 13:795934
Viruses, 2021, 13(4)580
Front Chem, 2020, 8:649
S8248 IQ-1 IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
S8327 KYA1797K KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).
Sci Rep, 2022, 12(1):7
mBio, 2021, 12(6):e0279221
Front Endocrinol (Lausanne), 2021, 12:676403
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
Sci Rep, 2022, 12(1):7
Neoplasia, 2019, 21(4):389-400
J Biol Chem, 2018, 293(52):20014-20028
S8429 PNU-74654 PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.
PLoS Pathog, 2022, 18(3):e1010354
Front Cell Dev Biol, 2022, 10:800181
Int J Mol Sci, 2022, 23(5)2834
S8474 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.
Sci Rep, 2022, 12(1):7
Acta Biochim Biophys Sin (Shanghai), 2021, gmab103
Cancers (Basel), 2020, 12(10)E3003
S8704 iCRT14 iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay.
PLoS Pathog, 2022, 18(3):e1010354
Theranostics, 2021, 11(6):2966-2986
S8761 Adavivint (SM04690) Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
PLoS Pathog, 2022, 18(3):e1010354
Mol Carcinog, 2021, 10.1002/mc.23308
Sci China Life Sci, 2021, 10.1007/s11427-021-1933-7
S8968 PRI-724 PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
EMBO Mol Med, 2022, e14990
Sci Rep, 2022, 12(1):7
mBio, 2021, 12(6):e0279221
S9416 Triptonide Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.
A5038 Beta Catenin Rabbit Recombinant mAb

Beta Catenin Antibody detects endogenous levels of total beta Catenin.

J Hematol Oncol, 2021, 14(1):178
Aging (Albany NY), 2021, 13(6):8989-9010
Cell Prolif, 2020, 53(6):e12825
A5072 Catenin alpha 1 Rabbit Recombinant mAb Catenin alpha 1 Rabbit Recombinant mAb detects endogenous levels of Catenin alpha 1.
S1263 Laduviglusib (CHIR-99021) Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
Cell Stem Cell, 2022, S1934-5909(22)00010-8
Adv Sci (Weinh), 2022, e2104299
Nat Commun, 2022, 13(1):1204
S2924 Laduviglusib (CHIR-99021) HCl Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.
Mol Cell, 2022, 82(6):1169-1185.e7
Adv Sci (Weinh), 2022, e2104299
Autophagy, 2022, 10.1080/15548627.2022.2055285
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
S3630 Methyl Vanillate Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
Sci Rep, 2022, 12(1):7
S6085 KY19382 (A3051) KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.
S7421 CGP 57380 CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.
J Cancer, 2020, 11(4):990-996
Bioorg Med Chem, 2018, 26(16):4602-4614
Cancer Lett, 2016, 10.1016/j.canlet.2016.02.052
S7914 Isoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.
Front Cell Dev Biol, 2021, 9:728352
S7954 CP21R7 (CP21) CP21R7 (CP21) is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
Sci Rep, 2022, 12(1):7
ACS Nano, 2021, 10.1021/acsnano.1c06452
Sci Adv, 2020, 6(30):eaba7606
S8178 Wnt agonist 1 Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
Sci Rep, 2022, 12(1):7
Oncol Rep, 2022, 47(3)50
Cell, 2021, 184(1):243-256.e18
S0733 Tegatrabetan (BC-2059) Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
S8647 iCRT3 iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.
EMBO Mol Med, 2022, e14990
Gastroenterology, 2021, S0016-5085(21)03489-2
Cancer Manag Res, 2021, 13:1901-1907
S5815 WAY-316606 WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.
J Bone Miner Res, 2021, 10.1002/jbmr.4435
S8320 SKL2001 SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.
Int J Biol Sci, 2022, 18(5):2032-2046
Sci Rep, 2022, 12(1):7
Cell Mol Life Sci, 2021, 10.1007/s00018-021-03972-x
S9828 WAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1).
S0458 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
S2431 TMTD (Tetramethylthiuram disulfide) TMTD (Tetramethylthiuram disulfide) can reduce the growth performance of chickens through decreasing liver index, whereas increasing kidney, cardiac, and spleen index, and induces tibial dyschondrolplasia (TD) by changing the expressions of VEGF, HIF-1α and WNT4. TMTD (Tetramethylthiuram disulfide) is widely used in rubber processing as an ultra accelerator for low-temperature cures and in agriculture as an important pesticide.
S5992 Heparan Sulfate Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
S6961 Foxy-5 Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.
E0033New IWP-4

IWP-4 is a potent Wnt/β-catenin signaling pathway inhibitor with an IC50 of 25 nM.

E0072New Indirubin-3′-oxime Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
S6699New Gigantol Gigantol is a bibenzyl component isolated from several medicinal orchids, which can inhibit Wnt/β-catenin pathway and has anti-tumor activity.
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