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Catalog No. Product Name Information Product Use Citations Product Validations
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S3408 A286982 A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
J Clin Invest, 2022, e126155
Acta Neuropathol Commun, 2022, 10(1):65
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
Adv Sci (Weinh), 2022, e2200053
J Clin Invest, 2022, e126155
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Nat Commun, 2022, 13(1):3117
Nat Methods, 2021, 18(1):84-91
Anal Chim Acta, 2021, 1151:338222
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Int J Mol Sci, 2021, 22(16)8410
Cell Death Dis, 2020, 14;11(4):230
Elife, 2019, 8
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cancers (Basel), 2022, 14(10)2430
Sci Rep, 2022, 12(1):9062
Stem Cell Res Ther, 2021, 12(1):523
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Immunity, 2021, S1074-7613(21)00289-2
J Extracell Vesicles, 2021, 10(8):e12091
Nat Commun, 2020, 11(1):282
A5051 Integrin beta-1/CD29 Rabbit Recombinant mAb Integrin beta-1/CD29 Rabbit Recombinant mAb detects endogenous levels of total Integrin beta 1.
A5062 Integrin alpha 6 Rabbit Recombinant mAb Integrin alpha 6 Rabbit Recombinant mAb detects endogenous levels of total Integrin alpha 6.
A5069 CD11a Rabbit Recombinant mAb CD11a Rabbit Recombinant mAb detects endogenous levels of CD11a.
A5126 Integrin alpha 2 Rabbit Recombinant mAb Integrin alpha 2 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 2.
A5136 Integrin alpha 4 Rabbit Recombinant mAb Integrin alpha 4 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 4.
A5174 Integrin beta 3 Rabbit Recombinant mAb Integrin beta 3 Rabbit Recombinant mAb detects endogenous level of total Integrin beta 3.
A5201 Integrin alpha 5 Rabbit Recombinant mAb Integrin alpha 5 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 5.
A5231 Calreticulin Rabbit Recombinant mAb Calreticulin Rabbit Recombinant mAb detects endogenous level of total Calreticulin.
A5246 HAPLN1 Rabbit Recombinant mAb HAPLN1 Rabbit Recombinant mAb detects endogenous level of HAPLN1.
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S3714 Lifitegrast Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
J Biomol Struct Dyn, 2020, 1-14
S8454 ATN-161 (Ac-PHSCN-NH2) ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Oncogene, 2022, 10.1038/s41388-022-02333-7
Bioact Mater, 2021, 6(7):2039-2057
Eur Rev Med Pharmacol Sci, 2021, 25(3):1233-1241
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
J Inflamm Res, 2021, 14:1341-1356
Research Square, 2021, 10.21203/rs.3.rs-870799/v1
bioRxiv, 2020, 10.1101/2020.11.25.398701
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S3408 A286982 A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
J Clin Invest, 2022, e126155
Acta Neuropathol Commun, 2022, 10(1):65
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
Adv Sci (Weinh), 2022, e2200053
J Clin Invest, 2022, e126155
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Nat Commun, 2022, 13(1):3117
Nat Methods, 2021, 18(1):84-91
Anal Chim Acta, 2021, 1151:338222
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Int J Mol Sci, 2021, 22(16)8410
Cell Death Dis, 2020, 14;11(4):230
Elife, 2019, 8
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cancers (Basel), 2022, 14(10)2430
Sci Rep, 2022, 12(1):9062
Stem Cell Res Ther, 2021, 12(1):523
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Immunity, 2021, S1074-7613(21)00289-2
J Extracell Vesicles, 2021, 10(8):e12091
Nat Commun, 2020, 11(1):282
A5051 Integrin beta-1/CD29 Rabbit Recombinant mAb Integrin beta-1/CD29 Rabbit Recombinant mAb detects endogenous levels of total Integrin beta 1.
A5062 Integrin alpha 6 Rabbit Recombinant mAb Integrin alpha 6 Rabbit Recombinant mAb detects endogenous levels of total Integrin alpha 6.
A5069 CD11a Rabbit Recombinant mAb CD11a Rabbit Recombinant mAb detects endogenous levels of CD11a.
A5126 Integrin alpha 2 Rabbit Recombinant mAb Integrin alpha 2 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 2.
A5136 Integrin alpha 4 Rabbit Recombinant mAb Integrin alpha 4 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 4.
A5174 Integrin beta 3 Rabbit Recombinant mAb Integrin beta 3 Rabbit Recombinant mAb detects endogenous level of total Integrin beta 3.
A5201 Integrin alpha 5 Rabbit Recombinant mAb Integrin alpha 5 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 5.
A5231 Calreticulin Rabbit Recombinant mAb Calreticulin Rabbit Recombinant mAb detects endogenous level of total Calreticulin.
A5246 HAPLN1 Rabbit Recombinant mAb HAPLN1 Rabbit Recombinant mAb detects endogenous level of HAPLN1.
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S3714 Lifitegrast Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
J Biomol Struct Dyn, 2020, 1-14
S8454 ATN-161 (Ac-PHSCN-NH2) ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Oncogene, 2022, 10.1038/s41388-022-02333-7
Bioact Mater, 2021, 6(7):2039-2057
Eur Rev Med Pharmacol Sci, 2021, 25(3):1233-1241
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
J Inflamm Res, 2021, 14:1341-1356
Research Square, 2021, 10.21203/rs.3.rs-870799/v1
bioRxiv, 2020, 10.1101/2020.11.25.398701
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
Tags: Integrin inhibitor|Integrin agonist|Integrin activator|Integrin inducer|Integrin antagonist|Integrin signaling pathway|Integrin assay kit