Gap-Junction

Other Cytoskeletal Signaling Related Inhibitors

HSP Kinesin Microtubule Associated Integrin PAK Dynamin MLCK TACC3 Actin Cardiac Myosin

Cat.No.	Product Name	Information	Product Use Citations
S6946	Gap19	Gap19 is a nonapeptide derived from the cytoplasmic loop (CL) of Cx43 and acts as a selective connexin 43 (Cx43) hemichannel blocker. This compound blocks Cx43 hemichannels without inhibiting gap junctions (GJs) at IC50 of 6.5 μM when applied intracellulary.	Undergraduate Research Thesis, The Ohio State University, March 2025, nan European Respiratory Journal, December 12, 2024, 2301983
S0339	Gap 26	Gap 26, a connexin mimetic peptide that composeds of residue no. 63-75 of the extracellular loop 1 of connexin 43 (Cx43), is a gap junction inhibitor. This compound blocks photoliberating inositol-1,4,5-trisphosphate triggers ATP release.
E7978	Danegaptide	Danegaptide is a potent and orally active gap-junction modifier that improves cardiac conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model by enhancing gap-junction communication.
E0040	Gap 27	Gap 27 is a synthetic connexin-mimetic peptide and acts as a gap junction inhibitor. This compound is highly effective in interrupting co-operative cell-cell interactions, such as the synchronous beating of embryonic cardiomyocytes.