Home Stem Cells & Wnt PORCN

PORCN inhibitors

Other Stem Cells & Wnt Related Inhibitors

Wnt/beta-catenin OCT Stemness kinase Fascin SFRP
Cat.No. Product Name Information Product Use Citations Product Validations
S7037 Wnt-C59 (C59) Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
Nature, 2025, 10.1038/s41586-025-08721-9
Circ Res, 2025, 137(10):1279-1291
Adv Sci (Weinh), 2025, 12(25):e2501148
Verified customer review of Wnt-C59 (C59)
S7143 LGK974 (WNT974) LGK974 (WNT974) is a potent and specific PORCN inhibitor that inhibits Wnt signaling with an IC50 of 0.4 nM in TM3 cells, and is currently in Phase 1.
J Exp Clin Cancer Res, 2025, 44(1):19
Genome Res, 2025, 10.1101/gr.279684.124
J Biol Chem, 2025, 301(6):108529
Verified customer review of LGK974 (WNT974)
S7301 IWP-L6 IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
iScience, 2022, 25(10):105182
Sci Rep, 2022, 12(1):7
Carcinogenesis, 2020, 41(7):993-1004
S8645 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
bioRxiv, 2025, 2025.04.25.650475
Cancer Cell, 2022, S1535-6108(21)00662-0
S6616 ETC-159 ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.
Nat Commun, 2023, 14(1):2402
J Pathol, 2022, 10.1002/path.5868
S8644 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.