PORCN

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PORCN Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S6616 ETC-159 ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.
S7037 Wnt-C59 (C59) Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
Biomaterials, 2022, 280:121286
Sci Rep, 2022, 12(1):7
ACS Nano, 2021, 10.1021/acsnano.1c06452
S7143 LGK-974 LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.
Sci Rep, 2022, 12(1):7
Gastroenterology, 2021, S0016-5085(21)00095-0
EMBO J, 2021, e105770
S7301 IWP-L6 IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
Sci Rep, 2022, 12(1):7
Carcinogenesis, 2020, 41(7):993-1004
S8644 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
S8645 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
S6616 ETC-159 ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.
S7037 Wnt-C59 (C59) Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.
Biomaterials, 2022, 280:121286
Sci Rep, 2022, 12(1):7
ACS Nano, 2021, 10.1021/acsnano.1c06452
S7143 LGK-974 LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.
Sci Rep, 2022, 12(1):7
Gastroenterology, 2021, S0016-5085(21)00095-0
EMBO J, 2021, e105770
S7301 IWP-L6 IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
Sci Rep, 2022, 12(1):7
Carcinogenesis, 2020, 41(7):993-1004
S8644 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
S8645 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.