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Dynamin

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8047 Dynasore Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).
J Nanobiotechnology, 2025, 23(1):173
Cell Death Dis, 2025, 16(1):681
Blood Adv, 2025, bloodadvances.2024015296
Verified customer review of Dynasore
S7162 Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.
J Hazard Mater, 2025, 495:138854
Redox Biol, 2025, 86:103818
J Nanobiotechnology, 2025, 23(1):437
Verified customer review of Mdivi-1
S7163 Dyngo-4a (Hydroxy-Dynasore) Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.
Cell Res, 2025, 10.1038/s41422-025-01110-x
Nat Commun, 2025, 16(1):4487
J Extracell Vesicles, 2025, 14(2):e70042
Verified customer review of Dyngo-4a (Hydroxy-Dynasore)
S9887 P110 P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1.
Cell, 2024, S0092-8674(24)00638-X
Cell Mol Biol Lett, 2024, 29(1):31
Free Radic Biol Med, 2024, 228:183-196
E1432 TPH104m TPH104m is a thienopyrimidine-hydrazinyl analog that inhibits Drp1 phosphorylation and induces non-apoptotic TNBC cell death. It also significantly inhibits TNBC proliferation.
E7699New Dynole 34-2 Dynole 34-2 inhibits dynamin GTPase activity (IC50 values of 6.9 µM for dynamin1 and 14.2 µM for dynamin2). This compound exhibits antimitotic properties and induces apoptosis, evidenced by cell blebbing, DNA fragmentation, and PARP cleavage. Additionally, Dynole 34-2 suppresses receptor-mediated endocytosis (RME).
E1081 MiTMAB

MiTMAB is a selective dynamin inhibitor that targets the dynamin-phospholipid interaction. This compound inhibits dynamin GTPase activity with a Ki of 940 nM.
S5422 Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide (Octadecyltrimethylammonium bromide, OcTMAB, C18TAB) is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.