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Actin Inhibitors | Modulators

Actin Products

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  • Actin Inhibitors (8)
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Cat.No. Product Name Information Product Use Citations Product Validations
S7497 CK-636 CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
J Biol Chem, 2024, 300(12):107942
Elife, 2021, 10e65910
Theranostics, 2019, 9(25):7628-7647
S8184 Cytochalasin D Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. This compound inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.
Nat Commun, 2025, 16(1):4069
Cell Regen, 2025, 14(1):21
Cell Prolif, 2024, e13728.
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. This compound attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. It suppresses cancer cell migration and tumor metastasis.
Mol Oncol, 2020, 10.1002/1878-0261.12854
F0012 β-Actin Antibody [C21N23] ACTB,beta Actin,beta Actin Loading Control,beta-Actin,β-Actin
Cell Death Dis, 2025, 16(1):672
J Plast Surg Hand Surg, 2021, 55(5):284-293
F0017 α-Smooth Muscle Actin Antibody [L19D14] Actin, alpha-Smooth Muscle,Actin, α-Smooth Muscle,alpha smooth muscle Actin,Alpha-Smooth Muscle Actin,Smooth Muscle Actin,α-Actin,α-Smooth Muscle Actin, α-SMA, a-SMA
Bioact Mater, 2024, 34:51-63
J Plast Surg Hand Surg, 2021, 55(5):284-293
F0082 Actin Antibody [A24J5] Actin,Actin Ab-5,pan Actin,Pan-Actin
F0440 Neurofilament-L Antibody [L10B15]
F0695 Neurofilament-M Antibody [H7L9] 160 kD Neurofilament Medium,NEFM,Neurofilament 145 kDa,Neurofilament 160,Neurofilament 160 kDa,Neurofilament M,Neurofilament-M
F1648 PABP1 Antibody [H6J19] PABP, PABP1
F0278 Cofilin Antibody [D9A5] Cofilin,Cofilin 1
F2199 α Actinin 1/ACTN1 Antibody [C8H2] Actinin alpha,alpha Actinin/ACTN1,alpha-Actinin,α-Actinin
F2226 α smooth muscle Actin (acetyl Glu 3) + Actin γ2 (acetyl Glu3) Antibody [H16P9]
F0640 N-WASP Antibody [K15N2]
F0417 VASP Antibody [A20G16]
F1962 Phospho-Lamin A/C (Ser22) Antibody [D12F9]
F1379 Tropomyosin-1 Antibody [G4H1] Tropomyosin (Sarcomeric),Tropomyosin-1
F2176 SUN2 Antibody [D3P18]
F2446New γ Actin Antibody [A4H18] gamma Actin,gamma-Actin
F2365 Arp3 C-terminal Antibody [F20N23]
F2091 Fascin Antibody [N3C10]
F2612New ARPC2 Antibody [B10F4] ARPC2,p34-Arc/ARPC2
F2033 α Actinin 4 Antibody [D15C11] alpha Actinin 4,α-Actinin 4
F2681New Cytokeratin 5 Antibody [G20N20] Cytokeratin 5
F2188 Cytokeratin 13 Antibody [L12L19]
F2756New CCT2 Antibody [C14D6]
F1440 Gelsolin Antibody [D8P23]
F1636New Phospho-RAB10 (Thr73) Antibody [M19N14]
F1478New Phospho-Zyxin (Ser142/143) Antibody [L24L6]
E1042 SMIFH2

SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
Sci Rep, 2025, 15(1):34331
S6673 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. This compound decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
E0076 Simufilam dihydrochloride Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7 nAChR/TLR4 associations and downstream pathologies.
E2956 Cytochalasin C Cytochalasin C is a cell-permeable fungal metabolite that has been found in C. globosum. This compound is an inhibitor of actin polymerization. It induces the formation of nuclear rodlets.
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. This compound depolymerizes actin and decreases expression of actin and vinculin. It is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S7690 CK-666 CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.
Sci Rep, 2025, 15(1):34331
Res Sq, 2023, rs.3.rs-3372987
F2616New Cytokeratin 4 Antibody [G16J4]
S7497 CK-636 CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
J Biol Chem, 2024, 300(12):107942
Elife, 2021, 10e65910
Theranostics, 2019, 9(25):7628-7647
S8184 Cytochalasin D Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. This compound inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.
Nat Commun, 2025, 16(1):4069
Cell Regen, 2025, 14(1):21
Cell Prolif, 2024, e13728.
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. This compound attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. It suppresses cancer cell migration and tumor metastasis.
Mol Oncol, 2020, 10.1002/1878-0261.12854
E1042 SMIFH2

SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
Sci Rep, 2025, 15(1):34331
S6673 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. This compound decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
E2956 Cytochalasin C Cytochalasin C is a cell-permeable fungal metabolite that has been found in C. globosum. This compound is an inhibitor of actin polymerization. It induces the formation of nuclear rodlets.
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. This compound depolymerizes actin and decreases expression of actin and vinculin. It is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S7690 CK-666 CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.
Sci Rep, 2025, 15(1):34331
Res Sq, 2023, rs.3.rs-3372987
E0076 Simufilam dihydrochloride Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7 nAChR/TLR4 associations and downstream pathologies.
F2446New γ Actin Antibody [A4H18] gamma Actin,gamma-Actin
F2612New ARPC2 Antibody [B10F4] ARPC2,p34-Arc/ARPC2
F2681New Cytokeratin 5 Antibody [G20N20] Cytokeratin 5
F2756New CCT2 Antibody [C14D6]
F1636New Phospho-RAB10 (Thr73) Antibody [M19N14]
F1478New Phospho-Zyxin (Ser142/143) Antibody [L24L6]
F2616New Cytokeratin 4 Antibody [G16J4]