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Actin

Other Cytoskeletal Signaling Related Inhibitors

HSP Kinesin Microtubule Associated Integrin PAK Dynamin MLCK TACC3 Gap-Junction Cardiac Myosin
Cat.No. Product Name Information Product Use Citations Product Validations
S8184 Cytochalasin D Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.
Nat Commun, 2025, 16(1):4069
Cell Regen, 2025, 14(1):21
Cell Prolif, 2024, e13728.
S7497 CK-636 CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
J Biol Chem, 2024, 300(12):107942
Elife, 2021, 10e65910
Theranostics, 2019, 9(25):7628-7647
S7690 CK-666 CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.
Sci Rep, 2025, 15(1):34331
Res Sq, 2023, rs.3.rs-3372987
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. This compound attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. It suppresses cancer cell migration and tumor metastasis.
Molecular Oncology, 2021, 725-738
Mol Oncol, 2020, 10.1002/1878-0261.12854
E1042 SMIFH2

SMIFH2 is a specific inhibitor of formin that inhibits formin-driven actin polymerization in vitro with IC50s ranging from 5 to 15 μM for different formins.
Sci Rep, 2025, 15(1):34331
Scientific Reports, 2025, 34331
E0076 Simufilam dihydrochloride Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7 nAChR/TLR4 associations and downstream pathologies.
E2956 Cytochalasin C Cytochalasin C is a cell-permeable fungal metabolite that has been found in C. globosum. This compound is an inhibitor of actin polymerization. It induces the formation of nuclear rodlets.
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. This compound depolymerizes actin and decreases expression of actin and vinculin. It is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S6673 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. This compound decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.